... interests. 12 02 2013 23 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Polarity Laminin Extracellular matrix Par-1 Par-1b MARK2 RNF41 NRDP1 Ubiquitin ligase Epithelial cell polarity depends on extrinsic cues from the extracellular matrix (ECM...

... cleavage Nrdp1 RNF41 Type 1 cytokine receptor USP8 Ectodomain shedding The cellular sensitivity to a cytokine signal is tightly controlled to avoid aberrant, potentially pathological signaling. Many studies have focused on feedback inhibition mechanisms like phosphatases (Xu and Qu, 2008...

... and transport to the plasma membrane, internalisation and recycling, degradation and ectodomain shedding, but the molecular basis of how cells establish steady state receptor levels is poorly understood. Here, we report that ring finger protein 41 (RNF41, also known as E3 ubiquitin-protein ligase Nrdp1...