...., 2010). The G4esn was replaced with the full length of human Notch1, leaving only the extracellular domain. pcDNA5-TO-hDll4-mCherry has been described previously (Sprinzak et al., 2010). mCitrine-VE-Cadherin-N-10 was obtained from Addgene (Addgene plasmid 56319 ; deposited by Michael Davidson; RRID...

... regulating EGFR transcription in proliferating cells and Notch1 transcription in differentiating cells. In proliferative cells, the EGFR promoter is occupied by Ctip2, whereas Ctip2 is only recruited to the Notch1 promoter under differentiating conditions. Activation of EGFR signaling downregulates Ctip2...

..., and is highly coordinated by proteins that regulate epithelial cell polarity, such as aPKCζ. We recently reported that Eya1 phosphatase functions through aPKCζ–Notch1 signaling to control cell polarity in the lung epithelium. Here, we have extended these observations to TJ formation to demonstrate that Eya1...

...Mi-Yeon Kim; Jung-Soon Mo; Eun-Jung Ann; Ji-Hye Yoon; Jane Jung; Yun-Hee Choi; Su-Man Kim; Hwa-Young Kim; Ji-Seon Ahn; Hangun Kim; Kwonseop Kim; Hyang-Sook Hoe; Hee-Sae Park The Notch1 receptor is a crucial controller of cell fate decisions, and is also a key regulator of cell growth...