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Keywords: Notch signaling
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Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (24): jcs250738.
Published: 21 December 2020
... mechanisms lead to mechanopathologies, for example, osteoporosis, myopathies, fibrosis or cardiovascular disease. Therefore, sensing mechanical cues and integrating them with the biomolecular cell fate machinery is essential for the maintenance of health. The Notch signaling pathway regulates cell and tissue...
Journal Articles
J Cell Sci (2019) 132 (8): jcs223768.
Published: 15 April 2019
...) transgene system. Enforced Nr5a1 expression compromised ovarian development in 46,XX mice, resulting in late-onset infertility, but did not induce (ovo)testis differentiation. The phenotype was similar to that of XX mice lacking Notch signaling. The expression level of Notch2 was significantly reduced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (11): 2202–2212.
Published: 01 June 2016
... cells, we found that inhibiting ADAM10 reduced the number of FOXL2-positive cells in perinatal ovaries. Furthermore, inhibiting ADAM10 suppressed the activation of Notch signaling, and blocking Notch signaling also disrupted the recruitment of follicle progenitor cells. Taken together, these results...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 2083–2094.
Published: 01 May 2014
... of differentiating into various somatic cell types, including craniofacial and peripheral nerve tissues. Notch signaling plays important roles during neurogenesis; however, its function during human neural crest development is poorly understood. Here, we generated self-renewing premigratory neural-crest-like cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4320–4332.
Published: 15 September 2012
... the development of noradrenergic neurons in the mammalian brain are largely unknown. We report here that Rbpj, a key nuclear effector in the Notch signaling pathway, plays an essential role in LC neuron development in the mouse. Conditional inactivation of Rbpj in the dorsal rhombomere (r) 1, where LC neurons...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2561–2572.
Published: 01 August 2011
...Yujin Zhang; Winston W.-Y. Kao; Emanuele Pelosi; David Schlessinger; Chia-Yang Liu Notch signaling is pivotal for the morphogenesis and homeostasis of many tissues. We found that aberrant Notch activation in mouse neural-crest-derived periocular mesenchymal cells (POMCs), which contribute...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (7): 1355–1359.
Published: 01 April 2002
... showed almost no staining for m-Numb. Thus, a high level of Musashi1 expression could have led to the clonal expansion of the above-mentioned tumor cells by activating Notch signaling, presumably through the translational inhibition of m-Numb( Kanemura et al., 2001 ). Hyperactivation of Notch signaling...