... their resolution via the DNA repair pathways of non-homologous end joining (NHEJ) or homologous recombination (HR). We and others have shown that DDR activation requires DROSHA; however, whether DROSHA exerts its functions by associating with damage sites, what controls its recruitment, and how DROSHA influences...

... that aberrant DNA-dsb repair under hypoxia is a potential factor in hypoxia-mediated genetic instability. * Author for correspondence ([email protected]) 22 8 2011 © 2012. 2012 DNA double-strand breaks hypoxia non-homologous end joining DNA double-strand break sensors γ-H2AX...