... of cytoprotective nitric oxide (NO) during heat stress. Hence, the re-addition of spermidine to Atg32 mutant yeast is sufficient to both enhance NO production and restore respiratory growth during heat stress. Our findings uncover a previously unrecognized physiological role for yeast mitophagy in spermidine...

... has shown that plant peroxisomes contain other important molecules and enzymes, including nitric oxide (NO), peroxynitrite, a NADPH-recycling system, Ca 2+ and lipid-derived signals, such as jasmonic acid (JA) and nitro-fatty acid (NO 2 -FA). This highlights the potential for complex interactions...

... as the nitric oxide generation. Ca 2+ Calmodulin Catalase Glutathione Nitric oxide Peroxisome Ca 2+ is a cellular second messenger whose homeostasis is highly regulated in cells through different components including Ca 2+ pumps, channels, cation exchangers and Ca 2+ -binding proteins...

... stretching and maintenance of mouse urinary bladder smooth muscle strips and single myocytes at 30% and 18% beyond the initial length, respectively, resulted in Ca 2+ oscillations. Experiments indicated that mechanical stretching remarkably increased the production of nitric oxide (NO) as well...

...Sara Baldelli; Daniele Lettieri Barbato; Giuseppe Tatulli; Katia Aquilano; Maria Rosa Ciriolo ABSTRACT Neuronal nitric oxide synthase (nNOS) and peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α) are two fundamental factors involved in the regulation of skeletal muscle cell...

... ( tiglesias@iib.uam.es ; nacho@bbm1.ucm.es ) Competing interests The authors declare no competing interests. 20 12 2013 26 05 2014 © 2014. Published by The Company of Biologists Ltd 2014 Protein kinase D Nitric Oxide Endothelium eNOS eNOS-Ser1179 phosphorylation...

... in vascular permeability induced by inflammatory stimuli and vascular endothelial growth factor (VEGF). Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is crucial for VEGF-induced changes in permeability in vivo ; however, the molecular mechanism by which endogenous NO modulates endothelial...

...Huawen Ding; Kevin C. Keller; Ivann K. C. Martinez; Rose M. Geransar; Kai O. zur Nieden; Sandra G. Nishikawa; Derrick E. Rancourt; Nicole I. zur Nieden Summary Nitric oxide (NO) has been shown to play a crucial role in bone formation in vivo . We sought to determine the temporal effect...

..., hexokinase; NO . , nitric oxide; NO − 2/3 , nitrites and nitrates; NOS, nitric oxide synthase; PHI, phosphohexose isomerase; RNS, reactive nitrogen species; ROS, reactive oxygen species; Trx(SH) 2 , reduced thioredoxin; Trx(S-S), oxidized thioredoxin; TrxR, thioredoxin reductase. In addition...

... chondrocytes have severely reduced levels of inducible nitric oxide synthase (iNOS) protein and nitric oxide (NO) production. NO donors reversed the proliferative effects induced by Rac1 deficiency, whereas inhibition of NO production mimicked the effects of Rac1 loss of function. Examination of the growth...

... that cellular CRM1 became S-nitrosylated after extensive exposure to endogenous or exogenous nitric oxide (NO). This abrogated the interaction of CRM1 with nuclear export signals (NESs) and repressed classical protein export. Analysis by mass spectrometry and involving the use of S-nitrosylation mimetic...

..., with concomitant tyrosine phosphorylation of p130Cas and activation of Rac-1. Furthermore, activation of integrin α9β1 also enhanced NO production through activation of inducible nitric oxide synthase (iNOS). Inhibition of Src tyrosine kinase or NOS decreased integrin-α9β1-dependent cell migration. Src appeared...

.... These changes are dependent on the generation of nitric oxide (NO) by an inducible NO synthase that becomes a significant consumer of oxygen. Furthermore, in these activated cells there is a biphasic stabilization of the hypoxia-inducible factor HIF1α, the second phase of which is also dependent on the presence...

... could then be rescued by treatment with N(G)-nitro-l-arginine, a nitric oxide synthase (NOS) inhibitor. Nitric oxide (NO), which was produced in cells that stably express endothelial NOS (eNOS) and brain NOS (bNOS), also induced the inhibition of Notch1 signaling. The NO-induced inhibition of Notch1...

...Bruno Almeida; Sabrina Buttner; Steffen Ohlmeier; Alexandra Silva; Ana Mesquita; Belém Sampaio-Marques; Nuno S. Osório; Alexander Kollau; Bernhard Mayer; Cecília Leão; João Laranjinha; Fernando Rodrigues; Frank Madeo; Paula Ludovico Nitric oxide (NO) is a small molecule with distinct roles...

... of this modification on lamellipodial structure and function are unknown. To examine the functional effects of this modification in living cells, we studied VASP phosphorylation at Ser239 by nitric oxide (NO) stimulation of cGMP-dependent protein kinase. Using live cell imaging of primary cells transfected with GFP...

...Beatrice B. Yaroslavskiy; Allison C. Sharrow; Alan Wells; Lisa J. Robinson; Harry C. Blair In skeletal remodeling, osteoclasts degrade bone, detach and move to new locations. Mechanical stretch and estrogen regulate osteoclast motility via nitric oxide (NO). We have found previously...

...Beata Wojciak-Stothard; Belen Torondel; Lillian Yen Fen Tsang; Ingrid Fleming; Beate Fisslthaler; James M. Leiper; Patrick Vallance Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide production associated with abnormal blood vessel growth and repair, however, the mechanism of action...

..., E. and Nisoli, E. ( 2005 ). Nitric oxide and mitochondrial biogenesis: a key to long-term regulation of cellular metabolism. Comp. Biochem. Physiol. 142A , 102 -110. Coburn, R. F. and Forman, H. J. ( 1987 ). Carbon Monoxide . Rockville, MD: American Physiological Society. Cronje, F. J...

...Miriam Palacios-Callender; Veronica Hollis; Nanci Frakich; Jesús Mateo; Salvador Moncada Nitric oxide (NO), generated endogenously in NO-synthase-transfected cells, increases the reduction of mitochondrial cytochrome c oxidase (CcO) at O 2 concentrations ([O 2 ]) above those at which it inhibits...