... were able to differentiate between the proximal and distal effects of oxidative stress and glial-derived neurotrophic factor (GDNF), demonstrating a dying-back degeneration and retrograde transmission of pro-survival signaling, respectively. Furthermore, we show that GDNF acts differently on motoneuron...

... organisms. Here we demonstrate that co-stimulation of dorsal root ganglion neurons with neurotrophic factors (NTFs) – glial-cell-line-derived neurotrophic factor, neurturin or nerve growth factor – and laminin leads to axonal growth that requires activation of Src family kinases (SFKs). A different, SFK...

...Alun M. Davies; Yves Larmet; Edwina Wright; Kristine S. Vogel ABSTRACT In the developing vertebrate nervous system the survival of sensory neurons becomes dependent on neurotrophic factors when their axons reach their target fields, and the synthesis of nerve growth factor (NGF) by target field...