..., thereby balancing these two components to maintain sustained neurotransmission. Fig. 6. The effects of FOR on neurotransmitter release can occur independent ly   of changes in nerve terminal growth. (A) Representative images of third-instar larval NMJs stained with anti-HRP. (B) The number of 1b...

... largely remain elusive. Here, we demonstrate the relevance of the priming factor CAPS1 (also known as CADPS) for the maturation and exocytosis of BDNF-containing secretory granules, as well as for neurotransmitter release from synaptic vesicles. Using live-cell imaging and RNA silencing methods, we show...

...Mirko Messa; Sonia Congia; Enrico Defranchi; Flavia Valtorta; Anna Fassio; Franco Onofri; Fabio Benfenati Synapsins are synaptic vesicle (SV)-associated phosphoproteins involved in the regulation of neurotransmitter release. Synapsins reversibly tether SVs to the cytoskeleton...

... in spontaneous neurotransmitter release at the peripheral and central synapses by selective activation of Ca v 2.2 channels. We found that GLTx stimulates the very high frequency, long-lasting (more than 10 hours) spontaneous release of acetylcholine by promoting nerve terminal Ca 2+ oscillations sensitive...

... for correspondence (e-mail: ornella.rossetto@unipd.it ) 11 3 2004 © The Company of Biologists Limited 2004 2004 Snake presynaptic neurotoxins Phospholipase A2 Synaptic vesicle recycling Neurotransmitter release Synaptic vesicles Several presynaptic neurotoxins endowed...

.... Decrease in neurotransmitter release in fat-3 mutants could be caused by a number of possible mechanisms. For example, synaptic vesicles could be assembled and localized normally to NMJs but undergo exocytosis only inefficiently. In this view, the number of vesicles at NMJs is expected to increase...