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Keywords: Neuroprotection
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J Cell Sci (2017) 130 (18): 3023–3039.
Published: 15 September 2017
... neuroprotection to that observed upon Cdk5 depletion, suggesting that Mcl-1 degradation by direct phosphorylation is a key mechanism by which Cdk5 promotes neurotoxicity in AD. The clinical significance of the Mcl-1-Cdk5 axis was investigated in human AD clinical specimens, revealing an inverse correlation...
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J Cell Sci (2012) 125 (6): 1556–1567.
Published: 15 March 2012
... death and ischemic tolerance . Stroke   39 , 3042 - 3048 . Corse   A. M. , Bilak   M. M. , Bilak   S. R. , Lehar   M. , Rothstein   J. D. , Kuncl   R. W. ( 1999 ). Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degeneration...
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J Cell Sci (2007) 120 (15): 2663–2671.
Published: 1 August 2007
[email protected] ) 17 5 2007 © The Company of Biologists Limited 2007 2007 Neuroprotection Prion Huntingtin Proteasome activity Reactive oxygen species The normal cellular prion protein (PrP C ) is a glycosylphosphatidylinositol-anchored glycoprotein that is predominantly expressed...
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J Cell Sci (2005) 118 (19): 4511–4525.
Published: 1 October 2005
..., such as phorbol esters and bryostatin 1, induced neuronal survival and neurite regrowth in a manner dependent on the activation of PKCβI. The neuroprotective effects of PKC activators were suppressed by pre-treatment with LY294002 (a PI3K inhibitor) and with U0126 (a MEK inhibitor), indicating that PKC activators...