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Keywords: Neuron
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Journal Articles
J Cell Sci (2023) 136 (11): jcs260638.
Published: 6 June 2023
...Maria Markaki; Dikaia Tsagkari; Nektarios Tavernarakis ABSTRACT Neurons are highly polarized, post-mitotic cells that are characterized by unique morphological diversity and complexity. As highly differentiated cells that need to survive throughout organismal lifespan, neurons face exceptional...
Journal Articles
In collection:
Cytoskeleton , Imaging
J Cell Sci (2022) 135 (7): jcs259234.
Published: 8 April 2022
...Joseph Atherton; Melissa Stouffer; Fiona Francis; Carolyn A. Moores ABSTRACT Neurons extend axons to form the complex circuitry of the mature brain. This depends on the coordinated response and continuous remodelling of the microtubule and F-actin networks in the axonal growth cone. Growth cone...
Includes: Supplementary data
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Proteostasis
J Cell Sci (2020) 133 (24): jcs247841.
Published: 23 December 2020
... mechanistic evidence indicating that ubiquitin carboxyl-terminal hydrolase 8 (USP8) modulates BDNF- and TrkB-dependent neuronal differentiation. USP8 binds to the C-terminus of TrkB using its microtubule-interacting domain (MIT). Immunopurified USP8 deubiquitylates TrkB in vitro , whereas knockdown of USP8...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs228973.
Published: 9 September 2019
...Shinji Kondo; Hidemasa Kato; Yutaka Suzuki; Toyoyuki Takada; Masamitsu Eitoku; Toshihiko Shiroishi; Narufumi Suganuma; Sumio Sugano; Hidenori Kiyosawa ABSTRACT We developed an in vitro system to differentiate embryonic stem cells (ESCs) derived from reciprocally crossed F1 hybrid mice into neurons...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs216101.
Published: 9 July 2018
... neurodevelopmental and psychiatric disorders. Many extracellular factors have been postulated as regulators of dendritic growth. Wnt proteins play a critical role in neuronal development and circuit formation. We previously demonstrated that Wnt7b acts through the scaffold protein dishevelled 1 (Dvl1) to modulate...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (4): jcs210450.
Published: 22 February 2018
... found in neurons of both the central and peripheral nervous system. The narrow tubules appear to be the most abundant form of ER in axons, and are also found interspersed in the cell bodies and dendrites. At the site of branch points, there is a small sheet that has a similarly narrow lumen...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2017) 130 (24): 4120–4131.
Published: 15 December 2017
...Brian V. Jenkins; Harriet A. J. Saunders; Helena L. Record; Dena M. Johnson-Schlitz; Jill Wildonger ABSTRACT Microtubules are essential for neuronal structure and function. Axonal and dendritic microtubules are enriched in post-translational modifications that impact microtubule dynamics, transport...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (20): 3832–3844.
Published: 15 October 2016
... © 2016. Published by The Company of Biologists Ltd 2016 Highlighted Article: We report a new role for sortilin (Sort1) as a negative regulator of Sonic hedgehog trafficking to axons and secretion from cells. Hedgehog Sortilin Trafficking Secretion Neuron Golgi Canadian...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1635–1648.
Published: 15 April 2016
..., Atl inhibits bone morphogenetic protein (BMP) signaling, and loss of atl causes age-dependent locomotor deficits in adults. These results demonstrate a crucial role for ER in neuronal function, and identify mechanistic links between ER morphology, neuronal function, BMP signaling and adult behavior...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (15): 3382–3395.
Published: 1 August 2014
...José I. Valenzuela; Matías Jaureguiberry-Bravo; Daniela A. Salas; Omar A. Ramírez; Víctor H. Cornejo; Hsiangmin E. Lu; Thomas A. Blanpied; Andrés Couve ABSTRACT In neurons, secretory organelles within the cell body are complemented by the dendritic endoplasmic reticulum (ER) and Golgi outposts...
Journal Articles
J Cell Sci (2013) 126 (11): 2319–2329.
Published: 1 June 2013
...Mariella A. M. Franker; Casper C. Hoogenraad Summary Microtubule-based transport is essential for neuronal function because of the large distances that must be traveled by various building blocks and cellular materials. Recent studies in various model systems have unraveled several regulatory...
Journal Articles
J Cell Sci (2013) 126 (1): 77–89.
Published: 1 January 2013
... Integrin Adhesion Neuron Spine In the central nervous system (CNS), synapse formation is often referred to as a process in which initial contacts between axonal terminals and dendritic filopodia undergo changes in morphology and molecular content resulting in mature synapses. Besides...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (14): 3421–3429.
Published: 15 July 2012
...Akiko Asada; Taro Saito; Shin-ichi Hisanaga Summary Cdk5 is a member of the cyclin-dependent kinase (Cdk) family, which is activated by neuronal activators p35 or p39. Cdk5 regulates a variety of neuronal activities including migration, synaptic activity and neuronal death. p35 and p39 impart...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2095–2104.
Published: 1 May 2012
...William M. Saxton; Peter J. Hollenbeck Vigorous transport of cytoplasmic components along axons over substantial distances is crucial for the maintenance of neuron structure and function. The transport of mitochondria, which serves to distribute mitochondrial functions in a dynamic and non-uniform...
Journal Articles
J Cell Sci (2011) 124 (24): 4194–4202.
Published: 15 December 2011
... mitochondrial pathology can be demonstrated in many cell types, it is neurons that bear the brunt of cell death in PD. We studied the mitochondrial physiology of neurons and muscle cells with loss of function of the nuclear encoded mitochondrial protein PINK1. PINK1 is widely expressed in many types of tissues...
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (17): 3123–3136.
Published: 1 September 2009
...) on active neurons; however, the detailed cellular and molecular mechanisms underlying this process are still unclear. In our study, we developed a fluorescence ratiometric assay for surface TrkB receptors to investigate the mechanisms of recruitment of TrkB to the plasma membrane following chemical long...
Includes: Supplementary data