...Jacob Kushkuley; Walter K. H. Chan; Sangmook Lee; Joel Eyer; Jean-Francois Leterrier; Franck Letournel; Thomas B. Shea The phosphorylation of neurofilaments (NFs) has long been considered to regulate their axonal transport rate and in doing so to provide stability to mature axons. Axons contain...

... neurogenesis and neuronal differentiation. Here we examined whether p42/44 MAP kinase plays a role in axonal transport and the organization of neurofilaments (NFs) in axonal neurites. Dominant-negative p42/44 MAP kinase, anti-MAP kinase antisense oligonucleotides and the MAP kinase inhibitor PD98059 all...

...F. Fasani; A. Bocquet; P. Robert; A. Peterson; J. Eyer Neurofilaments are synthesised and assembled in neuronal cell bodies, transported along axons and degraded at the synapse. However, in several pathological situations they aggregate in cell bodies or axons. To investigate their turnover when...

...Thomas B. Shea; Jason T. Yabe; Daniela Ortiz; Aurea Pimenta; Patti Loomis; Robert D. Goldman; Niranjana Amin; Harish C. Pant Phosphorylation has long been considered to regulate neurofilament (NF) interaction and axonal transport, and, in turn, to influence axonal stability and their maturation...

..., such as IF-associated proteins. * Author for correspondence (e-mail: [email protected] ) © The Company of Biologists Limited 2004 2004 Vimentin Neurofilaments Keratin Intermediate filaments Cell behavior and function is controlled to a large extent by a cytoskeleton that consists...

...Steven S. M. Chin; Pompeo Macioce; Ronald K. H. Liem ABSTRACT The expression and assembly characteristics of carboxyl- and amino-terminal deletion mutants of rat neurofilament low M r (NF-L) and neurofilament middle M r (NF-M) proteins were examined by transient transfection of cultured fibroblasts...

...Don W. Cleveland; Mervyn J. Monteiro; Philip C. Wong; Steven R. Gill; John D. Gearhart; Paul N. Hoffman ABSTRACT The control of radial growth of axons is of functional importance because caliber is a principal determinant of conduction velocity in myelinated nerve fibers. Neurofilaments, the major...

...Maurizio Vitadello; Michela Matteoli; Luisa Gorza ABSTRACT We have recently shown that specialized myocytes of the rabbit heart express a cytoskeletal protein similar to the M subunit of neurofilaments (NF). Since this result was obtained using a single anti-NF-M monoclonal antibody, we tested...

... been most important. Twenty eight lung cancer cell lines were cultured for up to four years, and were examined at regular intervals for their intermediate filament protein (IFP) expression patterns using a panel of cytokeratin (CK) and neurofilament (NF) antibodies. These studies showed...

... intermediate filament (IF). (2) The three classic-type SCLC cell lines contain only cytokeratin IFs but not vimentin IF or neurofilaments (NFs). Cytokeratin polypeptides 7, 8, 18 and 19 could be detected. (3) All three variant-type SCLC cell lines do not contain detectable amounts of cytokeratins. In contrast...