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Keywords: Neurodegeneration
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Journal Articles
In collection:
Mitochondria
J Cell Sci (2023) 136 (13): jcs260993.
Published: 7 July 2023
... explores the prospect of import machinery perturbation as a cause of neurodegeneration instigated by the accumulation of aggregating proteins linked to disease. We found that the aggregation-prone Tau variant (Tau P301L ) reduces the levels of components of the import machinery of the outer (TOM20, encoded...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (11): jcs260638.
Published: 6 June 2023
... contributes to the maintenance of nervous system homeostasis. Defective or dysregulated mitophagy has been implicated in the pathogenesis of neurodegenerative diseases. Autophagy Energy homeostasis Mitochondria Mitophagy Nervous system Neurodegeneration Neurodegenerative diseases Neuron Non...
Journal Articles
J Cell Sci (2023) 136 (10): jcs260888.
Published: 31 May 2023
... manipulation. Autophagy Proteostasis network Neurodegeneration Austrian Science Fund http://dx.doi.org/10.13039/501100002428 P30401-B21 W1261 F79 Horizon 2020 Framework Programme http://dx.doi.org/10.13039/100010661 847548 All living systems must keep...
Includes: Supplementary data
Journal Articles
In collection:
Motors
J Cell Sci (2023) 136 (5): jcs260220.
Published: 31 October 2022
... as homozygotes, and the adult heterozygous animals have mild to severe neurodegeneration phenotypes ( Terenzio et al., 2018a ), raising the possibility that specific aspects of the phenotype might be due to effects of the point mutation rather than reduction in dynein levels. An allele deletion model allowing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (17): jcs260227.
Published: 8 September 2022
... by The Company of Biologists Ltd 2022 Summary: Mutations in VPS13A and XK cause related neurodegenerative disorders. A pathological VPS13A mutation disrupts binding of the VPS13A and XK proteins, suggesting a common basis of both diseases. Neurodegeneration Neuro-acanthocytosis syndromes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (19): jcs258561.
Published: 14 October 2021
.... Comparison with tomograms of degenerative retina from a mouse model of retinitis pigmentosa illustrates the potential of this method for analyzing disease processes like neurodegeneration at sub-200 nm resolution. As a non-destructive imaging method, PXCT is very suitable for correlative imaging. Within...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (19): jcs240465.
Published: 6 October 2021
... and neurons. Despite its importance in disease, mitophagy is likely dispensable under physiological conditions. This Review explores the in vivo roles of mitophagy in mammalian systems, focusing on the best studied examples – mitophagy in neurodegeneration, cardiomyopathy, metabolism, and red blood cell...
Journal Articles
J Cell Sci (2020) 133 (7): jcs228072.
Published: 7 April 2020
... in the cell and how they contribute to disease development. Ubiquitin HECT E3 ubiquitin ligase Ubiquitylation Protein-protein interactions Protein turnover Cell signaling Cancer Neurological disorders Neurodevelopmental disorders Neurodegeneration National Institutes of Health...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs228072.
Published: 7 April 2020
... they contribute to disease development. Ubiquitin HECT E3 ubiquitin ligase Ubiquitylation Protein-protein interactions Protein turnover Cell signaling Cancer Neurological disorders Neurodevelopmental disorders Neurodegeneration National Institutes of Health 10.13039/100000002...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs235044.
Published: 10 February 2020
... glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation both in vitro and in vivo . GDE2 is a prognostic marker in neuroblastoma, while loss of GDE2 leads to progressive neurodegeneration in mice; however, its regulation remains unclear. Here, we report that, in immature neuronal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs235044.
Published: 10 February 2020
... glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation both in vitro and in vivo . GDE2 is a prognostic marker in neuroblastoma, while loss of GDE2 leads to progressive neurodegeneration in mice; however, its regulation remains unclear. Here, we report that, in immature neuronal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs236836.
Published: 23 October 2019
... toxicity FUS cellular localisation Neurodegeneration Drosophila Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found throughout the cell that lack protein-coding function ( Lo Piccolo, 2018 ; Sun et al., 2018 ). It has been revealed nuclear-located lncRNAs form...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs236836.
Published: 23 October 2019
... toxicity FUS cellular localisation Neurodegeneration Drosophila Ministry of Education, Culture, Sports, Science and Technology 10.13039/501100001700 17H05699 Ministry of Health, Labour and Welfare 10.13039/501100003478 H24-Soyaku-Sogo-002 Japan Agency for Medical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs233221.
Published: 22 October 2019
... in Parkinson's disease, causes impaired activation of Akt as a result of defects in phospholipid PI(3,4,5)P 3 regulation. Akt Parkinson's disease PINK1 neurodegeneration PIP 3 PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] was identified as a gene upregulated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs233221.
Published: 22 October 2019
... in Parkinson's disease, causes impaired activation of Akt as a result of defects in phospholipid PI(3,4,5)P 3 regulation. Akt Parkinson's disease PINK1 neurodegeneration PIP 3 Irish Research Council for Science, Engineering and Technology 10.13039/501100001596 GOIPG/2015/3467...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (13): jcs231258.
Published: 1 July 2019
... , M. ( 2014 ). PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease . Neurobiol. Aging   35 , 2272 - 2281 . 10.1016/j.neurobiolaging.2014.04.031 Dolev , I. , Fogel , H. , Milshtein...
Journal Articles
J Cell Sci (2019) 132 (13): jcs231258.
Published: 1 July 2019
... Neurodegeneration European Molecular Biology Organization 10.13039/100004410 ALTF 979-2014 European Research Council 10.13039/100010663 Fundação para a Ciência e a Tecnologia 10.13039/501100001871 Champalimaud Foundation European Commission 10.13039...
Journal Articles
J Cell Sci (2018) 131 (22): jcs214684.
Published: 19 November 2018
.... and Banker , G. ( 2006 ). Culturing hippocampal neurons . Nat. Protoc.   1 , 2406 - 2415 . 10.1038/nprot.2006.356 Lau , A. and Tymianski , M. ( 2010 ). Glutamate receptors, neurotoxicity and neurodegeneration . Pflugers Arch.   460 , 525 - 542 . 10.1007/s00424-010-0809-1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs214684.
Published: 19 November 2018
... mediated by RIPK1, RIPK3 and MLKL controls axonal degeneration during neuronal excitotoxic damage. Neurodegeneration Axonal degeneration Excitotoxicity Necroptosis Fondo Nacional de Desarrollo Científico y Tecnológico 1171137 Geroscience Center for Brain Health and Metabolism...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs209122.
Published: 12 June 2018
... Supersaturation Proteostasis Neurodegeneration Ubiquitomics Degron Proteasome Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease, MND) is a progressive neurodegenerative disease leading to paralysis of voluntary muscles due to the death of motor neurons in the brain and spinal...
Includes: Supplementary data