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Keywords: Neurodegeneration
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Journal Articles
J Cell Sci (2021) 134 (19): jcs258561.
Published: 14 October 2021
.... Comparison with tomograms of degenerative retina from a mouse model of retinitis pigmentosa illustrates the potential of this method for analyzing disease processes like neurodegeneration at sub-200 nm resolution. As a non-destructive imaging method, PXCT is very suitable for correlative imaging. Within...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (19): jcs240465.
Published: 06 October 2021
... and neurons. Despite its importance in disease, mitophagy is likely dispensable under physiological conditions. This Review explores the in vivo roles of mitophagy in mammalian systems, focusing on the best studied examples – mitophagy in neurodegeneration, cardiomyopathy, metabolism, and red blood cell...
Journal Articles
J Cell Sci (2020) 133 (7): jcs228072.
Published: 07 April 2020
... they contribute to disease development. Ubiquitin HECT E3 ubiquitin ligase Ubiquitylation Protein-protein interactions Protein turnover Cell signaling Cancer Neurological disorders Neurodevelopmental disorders Neurodegeneration In 1995, it was discovered that an ∼350 amino acid region...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs235044.
Published: 10 February 2020
... glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation both in vitro and in vivo . GDE2 is a prognostic marker in neuroblastoma, while loss of GDE2 leads to progressive neurodegeneration in mice; however, its regulation remains unclear. Here, we report that, in immature neuronal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs236836.
Published: 23 October 2019
... DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation . Nat. Commun.   9 , 335 . 10.1038/s41467-017-02299-1 Neumann , M. , Roeber , S. , Kretzschmar , H. A. , Rademakers , R. , Baker , M. and Mackenzie , I. R...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs233221.
Published: 22 October 2019
... to neurodegeneration?   Front. Neurosci.   9 , 435 . 10.3389/fnins.2015.00435 Arena , G. and Valente , E. M. ( 2017 ). PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease . J. Pathol.   241 , 251 - 263 . 10.1002/path.4815 Arena , G...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (13): jcs231258.
Published: 01 July 2019
... protective role of cell competition against neurodegeneration, which involves the beneficial death of less fit neurons in amyloid-β-transgenic flies through fitness comparison ( Coelho et al., 2018 ). Amyloid-β (Aβ) is a small peptide formed by the sequential cleavage of the transmembrane amyloid precursor...
Journal Articles
J Cell Sci (2018) 131 (22): jcs214684.
Published: 19 November 2018
.... Neurodegeneration Axonal degeneration Excitotoxicity Necroptosis Neuronal excitotoxicity has been described as a contributing factor in several pathologies of the central nervous system (CNS), including Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs209122.
Published: 12 June 2018
... , A. and Ciechanover , A. ( 1998 ). The ubiquitin system . Annu. Rev. Biochem.   67 , 425 - 479 . 10.1146/annurev.biochem.67.1.425 Huang , Q. and Figueiredo-Pereira , M. E. ( 2010 ). Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications . Apoptosis   15...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs189928.
Published: 13 April 2018
.... and Trojanowski , J. Q. ( 2007 ). Tau-mediated neurodegeneration in Alzheimer's disease and related disorders . Nat. Rev. Neurosci.   8 , 663 - 672 . 10.1038/nrn2194 Bañez-Coronel , M. , Ayhan , F. , Tarabochia , A. D. , Zu , T. , Perez , B. A. , Tusi , S. K. , Pletnikova...
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (3): jcs211987.
Published: 08 February 2018
... cells using a model of neurodegeneration. Overall, this study highlights a role for the Golgi ribbon in pathways central to cellular homeostasis. This article has an associated First Person interview with the first author of the paper. * Author for correspondence ( pgleeson@unimelb.edu.au...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (18): 3023–3039.
Published: 15 September 2017
... between Mcl-1 levels and disease severity. These results emphasize the potential of Mcl-1 upregulation as an attractive therapeutic strategy for delaying or preventing neurodegeneration in AD. * Author for correspondence ( shah23@purdue.edu ) Competing interests The authors declare...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1772–1784.
Published: 15 May 2017
... integrity of the synapse – mutant NMJs present with progressive structural changes and upregulated autophagy, features commonly observed during ageing and in models of neurodegeneration. Unexpectedly, we find instances of nerve terminal detachment from the muscle fibre; to our knowledge, this is the first...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (2): 325–331.
Published: 15 January 2017
... as primary targets of α-synuclein, revealing 37 mitochondrial proteins not previously linked to α-synuclein or neurodegeneration pathways. Of these, sideroflexin 3 (SFXN3) was found to be a mitochondrial protein localized to the inner mitochondrial membrane. Loss of SFXN3 did not disturb mitochondrial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 71–82.
Published: 01 January 2017
..., are reviewed. Glioma Mechanobiology Mechanotransduction Microenvironment Neurodegeneration Differentiated tissues exhibit distinct mechanical properties ( Fig. 1 ), which direct their structure and function and reflect the composition and architecture of the extracellular matrix (ECM...
Journal Articles
J Cell Sci (2016) 129 (19): 3635–3647.
Published: 01 October 2016
... reticulum Neurodegeneration The maturation of newly synthesized polypeptides is a multi-step process that is assisted and supervised by a network of molecular chaperones ( Kim et al., 2013 ). Unlike cytosolic proteins, secreted and membrane proteins bear N-terminal signal peptides that mediate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1815–1830.
Published: 01 May 2016
... phosphorylation-resistant Foxo3 or by depleting Cdk5 or Foxo3, highlighting a key role for Cdk5 in regulating Foxo3. These results were confirmed in an Alzheimer's disease mouse model, which exhibited increased levels and nuclear localization of Foxo3 in hippocampal neurons, which preceded neurodegeneration...
Journal Articles
J Cell Sci (2015) 128 (23): 4279–4292.
Published: 01 December 2015
... growth. Dendrite Drosophila Exocyst Munc18-1 Neurodegeneration STXBP1 Axons and dendrites lengthen by several orders of magnitude during neuronal development, and this lengthening of neurites is essential for establishing the morphological features of a neuron that ultimately...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2391–2400.
Published: 01 June 2014
... in neurodegenerative diseases.   Trends Cell Biol.   22 , 169 – 175 . 10.1016/j.tcb.2011.11.003 Cruz   J. C. , Tseng   H. C. , Goldman   J. A. , Shih   H. , Tsai   L. H. ( 2003 ). Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary...
Journal Articles
J Cell Sci (2013) 126 (11): 2480–2492.
Published: 01 June 2013
... affected by Alzheimer’s disease. * These authors contributed equally to this work ‡ Author for correspondence ( thorsten.t.mueller@rub.de ) 13 03 2013 © 2013. Published by The Company of Biologists Ltd 2013 Morbus Alzheimer Mass spectrometry Neurodegeneration Nuclear...
Includes: Supplementary data