...-linked amyotrophic lateral sclerosis. Endolysosomes Neuritogenesis NSC34 cells Neurodegenerative diseases Phosphatidylinositol-4-phosphate Consiglio Nazionale delle Ricerche 10.13039/501100004462 Fondazione Regionale per la Ricerca Biomedica 2015-0023...

... and differentiated N2A cells. The expression of full-length IRSp53 or the LIN7ΔPDZ mutant lacking the domain for association with IRSp53 was unable to restore neuritogenesis in LIN7-silenced cells. Conversely, defective neuritogenesis could be rescued by the expression of RNAi-resistant full-length LIN7 or chimeric...

... shRNA. DYRK1A knockdown compromised neuritogenesis and was associated with alterations in microtubule stability. These experiments demonstrate that MAP1B has DYRK1A-primed and nonprimed GSK3β sites that are involved in the regulation of microtubule stability in growing axons. MAP1B was partially...

... Neuritogenesis Cell migration is driven by protrusive activity at the leading edge of the cell, where continuous remodelling of actin and adhesive sites are required. Experimental evidence indicates that membrane trafficking may contribute to the extension of the cell border required for protrusion...

... is regulated by actin-binding proteins. In this study, we describe for the first time, the role of profilin I and its ligand interactions in neuritogenesis of PC12 cells. High-level overexpression of wild-type profilin I had an inhibitory effect on neurite outgrowth. Low levels of profilin I did not disturb...

... 7 2005 © The Company of Biologists Limited 2005 2005 Cochlea Peripheral nervous system PKC Neuroprotection Signal transduction Neuritogenesis Primary afferent auditory neurons reside in the spiral ganglion (SG) and are bipolar neurons that extend a peripheral process...

.... In a previous work we demonstrated that laminin molecules could self-assemble in two different manners, giving rise to matrices that could favor either neuritogenesis or proliferation of cortical precursor cells. We investigated whether the ability of astrocytes to promote neuritogenesis of co-cultivated...

... dramatically increased the efficiency of laminin self-assembly, practically abolishing the necessity for a minimal protein concentration. Here we have characterized the morphologies of laminin matrices produced in either neutral or acidic conditions and compared their capacities to induce neuritogenesis of rat...

... ribosomes do not enter neurites while CCTα-containing chaperonins do, the latter may play roles, subsequent to translation, which influence cytoskeletal elaboration during neuritogenesis. * Author for correspondence (email: (c/o) [email protected]) † Present address: School of Biological...

... and how they are presented to the neurones. An example of such molecules is, for instance, J1/tenascin, which promoted axon extension as a substratum-bound molecule, but inhibited outgrowth as a soluble molecule (Lochter et al., 1991). development neuritogenesis neuron polarity proteoglycan...