..., we report that p75 NTR signals very differently in hippocampal neurons (HCNs) and cerebellar granule neurons (CGNs), and we present evidence indicating that this is partly controlled by differential proteolytic cleavage. Nerve growth factor (NGF) induced caspase‐3 activity and cell death in HCNs...

... Octubre, Madrid, Spain 15 7 2009 © The Company of Biologists Limited 2009 2009 Intracellular signaling Nerve growth factor Receptor activation Receptor dimerization Nervous system development and function is regulated by the action of both cell intrinsic determinants...

..., tenascin C and osteopontin. We found that this integrin is a receptor for nerve growth factor (NGF) and two other neurotrophins, brain-derived neurotrophic factor and NT3, using a cell adhesion assay with the α9SW480 cell line. Interaction of α9β1 with NGF was confirmed in an ELISA assay by direct binding...

... or nerve growth factor (NGF). The effect of NGF was mediated by the TrkA receptor and the ERK1-ERK2 kinase kinase pathway. Fos and Fra1 transcription were induced within the first hour after addition of the neurotrophin, but, unlike what is observed after serum induction in the same cells, a second wave...

...José María Frade ABSTRACT During their early postmitotic life, a proportion of the nascent retinal ganglion cells (RGCs) are induced to die as a result of the interaction of nerve growth factor (NGF) with the neurotrophin receptor p75. To analyse the mechanisms by which NGF promotes apoptosis...

... in regulation of the balance between cell proliferation and apoptotic cell death in the otic vesicle. The sphingomyelin pathway signals apoptosis for nerve growth factor upon binding to p75 receptors. It is initiated by sphingomyelin hydrolysis to generate the second messenger ceramide. In the present study, we...

...). In these neurons, apoptosis can be induced by the withdrawal of nerve growth factor (NGF) and also by the addition of the kinase inhibitor staurosporine. p35 has been shown to be a broad spectrum inhibitor of the caspase family and promotes the survival of SCG neurons withdrawn from NGF. We show that p35 is also...

...Trevor R. Jackson; Ira J. Blader; Latanya P. Hammonds-Odie; Christina R. Burga; Frank Cooke; Phillip T. Hawkins; Andrea G. Wolf; Katherine A. Heldman; Anne B. Theibert ABSTRACT Application of nerve growth factor (NGF) to PC12 cells stimulates a programme of physiological changes leading...

... that exhibit altered neurite outgrowth properties in response to nerve growth factor (NGF). We describe here a PC12 cell sub-clone, designated PC12-clone 41 (PC12-C41), that displays significant increases in neurite abundance and stability when compared with the parental line. This difference does not appear...

...Alun M. Davies; Yves Larmet; Edwina Wright; Kristine S. Vogel ABSTRACT In the developing vertebrate nervous system the survival of sensory neurons becomes dependent on neurotrophic factors when their axons reach their target fields, and the synthesis of nerve growth factor (NGF) by target field...

...N. Q. Mcdonald; R. Lapatto; J. Murray-Rust; T. L. Blundell ABSTRACT The largest and best characterised family of neurotrophic growth factors is that of nerve growth factor (NGF) and its relatives. In order to understand the relation of structure and function, we have undertaken X-ray analyses...