... pathways is part of a negative feedback mechanism controlling chemoattractant signal transduction during Dictyostelium chemotaxis. Fig. 8. Proposed model for the role of PKA in regulating the chemoattractant signal transduction pathways in Dictyostelium . Although PKA controls gene expression...

... in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their functional interaction with the upstream Wnt pathway component Dvl. Conductin shows reduced binding to Dvl2 compared to axin, and degradation of β-catenin by conductin is only poorly blocked by Dvl2. We propose...