...; Barry Honig; Lawrence Shapiro; Roberto Cattaneo ABSTRACT Here, we show that cells expressing the adherens junction protein nectin-1 capture nectin-4-containing membranes from the surface of adjacent cells in a trans -endocytosis process. We find that internalized nectin-1–nectin-4 complexes follow...

...Regina B. Troyanovsky; Indrajyoti Indra; Chi-Shuo Chen; Soonjin Hong; Sergey M. Troyanovsky ABSTRACT The mechanism that coordinates activities of different adhesion receptors is poorly understood. We investigated this mechanism by focusing on the nectin-2 and E-cadherin adherens junction receptors...

... conditions mimicking vascular flow. Drebrin knockdown leads to weakening of cell–cell contacts, characterized by loss of nectin from adherens junctions and its subsequent lysosomal degradation. Immunoprecipitation, FRAP and mitochondrial re-targeting experiments show that nectin stabilization occurs through...

... a variety of cellular patterns, including mosaic patterns. At least three types of cell–cell adhesion have been observed: symmetric homotypic, asymmetric homotypic and heterotypic cell adhesions. Cadherins and nectins, which are known cell–cell adhesion molecules, mediate these cell adhesions. Cadherins...

...Noriyuki Kanzaki; Hisakazu Ogita; Hitomi Komura; Misa Ozaki; Yasuhisa Sakamoto; Takashi Majima; Takeshi Ijuin; Tadaomi Takenawa; Yoshimi Takai The nectin-afadin complex is involved in the formation of cell-cell junctions, such as adherens junctions (AJs) and tight junctions (TJs). Nectins are Ca 2...

... molecule (CAM). TJs are formed at the apical side of adherens junctions (AJs), where E-cadherin and nectin are major CAMs. We have revealed that nectin first forms cell-cell adhesions, and then recruits cadherin to nectin-based cell-cell adhesion sites to form AJs and subsequently recruits claudin...

...Shigeki Kakunaga; Wataru Ikeda; Shinsuke Itoh; Maki Deguchi-Tawarada; Toshihisa Ohtsuka; Akira Mizoguchi; Yoshimi Takai Nectins are Ca 2+ -independent immunoglobulin-like cell-cell adhesion molecules and comprise a family of four members. At the mossy fiber terminals of hippocampus, nectin-1...

...Yoshimi Takai; Hiroyuki Nakanishi The cadherin superfamily plays key roles in intercellular adhesion. An emerging intercellular adhesion system, consisting of nectin and afadin, also has roles in organization of a variety of intercellular junctions either in cooperation with, or independently...