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Keywords: Necroptosis
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Journal Articles
J Cell Sci (2022) 135 (17): jcs260091.
Published: 13 September 2022
...Kidong Kang; Christa Park; Francis Ka-Ming Chan ABSTRACT Necroptosis, or programmed necrosis, is an inflammatory form of cell death with important functions in host defense against pathogens and tissue homeostasis. The four cytosolic receptor-interacting protein kinase homotypic interaction motif...
Includes: Supplementary data
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J Cell Sci (2019) 132 (5): jcs220996.
Published: 28 February 2019
...Daniel Frank; David L. Vaux; James M. Murphy; James E. Vince; Lisa M. Lindqvist ABSTRACT Necroptosis is an inflammatory form of programmed cell death mediated by the pseudokinase mixed-lineage kinase domain-like protein (MLKL). Upon phosphorylation by receptor-interacting protein kinase-3 (RIPK3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs214684.
Published: 19 November 2018
... degenerative mechanisms in different compartments of the same cell. The identification of necroptosis as a key mechanism of axonal degeneration after excitotoxicity is an important initial step in the development of novel therapeutic strategies for nervous system disorders. References Adalbert , R...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2135–2144.
Published: 15 May 2014
.... The best-studied form of programmed cell death is apoptosis, a process that requires activation of caspase proteases. Recently it has been appreciated that various non-apoptotic forms of cell death also exist, such as necroptosis and pyroptosis. These non-apoptotic cell death modalities can be either...
Journal Articles
J Cell Sci (2014) 127 (4): 896–907.
Published: 15 February 2014
... and ethanol in promoting hepatocyte sensitivity to TNFα-induced necroptosis. Concurrent exposure to fructose and ethanol induces the overexpression of the CDGSH iron-sulfur domain-containing protein 1 (CISD1 or mitoneet), which is localized to the outer mitochondrial membrane. The increased expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2995–3003.
Published: 15 June 2012
...Nataly Shulga; John G. Pastorino Summary Tumor necrosis factor (TNF) can induce necroptosis, wherein inhibition of caspase activity prevents apoptosis but initiates an alternative programmed necrosis. The activity of receptor-interacting serine/threonine-protein kinase 1 (RIPK-1) is required...
Includes: Supplementary data