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Keywords: NF-κB
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Journal Articles
J Cell Sci (2020) 133 (12): jcs239822.
Published: 15 June 2020
...Thomas O'Loughlin; Antonina J. Kruppa; Andre L. R. Ribeiro; James R. Edgar; Abdulaziz Ghannam; Andrew M. Smith; Folma Buss ABSTRACT Optineurin (OPTN) is a multifunctional protein involved in autophagy and secretion, as well as nuclear factor κB (NF-κB) and IRF3 signalling, and OPTN mutations are...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs236141.
Published: 28 October 2019
... fruit fly models of chronic inflammation. Ectopic Toll/NF-κB and JAK/STAT signaling in mutant D. melanogaster results in overproliferation of hematopoietic blood progenitors resulting in the formation of granuloma-like tumors. Ectopic JAK-STAT signaling also leads to metabolic inflammation. We report...
Journal Articles
J Cell Sci (2016) 129 (11): 2261–2272.
Published: 01 June 2016
... activation of receptor-interacting serine/threonine-protein kinase 2 (RIP2; also known as RIPK2), and subsequent activation of NF-κB signaling and anti-apoptosis gene expression in B-lymphoproliferative cells. Furthermore, PAX5 is able to interact with RIP1 and RIP3, modulating both RIP1-mediated TNFR and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1775–1780.
Published: 01 May 2016
...Tiphaine Douanne; Julie Gavard; Nicolas Bidère ABSTRACT Antigen-receptor-mediated activation of lymphocytes relies on a signalosome comprising CARMA1 (also known as CARD11), BCL10 and MALT1 (the CBM complex). The CBM activates nuclear factor κB (NF-κB) transcription factors by recruiting the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1580–1591.
Published: 15 April 2016
...Arif Yurdagul, Jr; Florian J. Sulzmaier; Xiao L. Chen; Christopher B. Pattillo; David D. Schlaepfer; A. Wayne Orr ABSTRACT Oxidized low-density lipoprotein (oxLDL) accumulates early in atherosclerosis and promotes endothelial nuclear factor κB (NF-κB) activation, proinflammatory gene expression and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1455–1467.
Published: 01 April 2016
...Laiqun Zhang; Ken Blackwell; Lauren M. Workman; Katherine N. Gibson-Corley; Alicia K. Olivier; Gail A. Bishop; Hasem Habelhah ABSTRACT The role of TRAF2 and TRAF5 in TNFα-induced NF-κB activation has become complicated owing to the accumulation of conflicting data. Here, we report that 7-day-old...
Journal Articles
J Cell Sci (2016) 129 (1): 108–120.
Published: 01 January 2016
... different taxa in vertebrates revealed several conserved regions in the TNF sequence. By screening overlapping peptides derived from human TNF to determine their role in three different TNF-induced processes – apoptosis, necrosis and NF-κB stimulation – we found that TNF conserved regions are mostly related...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 39–50.
Published: 01 January 2016
... factor κB (NF-κB) in both myoblasts and skeletal muscle tissue. Our data illustrate that the signaling pathway NF-κB–miR-195/497–Igf1r/Insr-Ccnd2/Ccne1 plays important roles in myogenesis. Our study provides novel evidence for the roles of miR-195 and miR-497 in muscle development. * These authors...
Journal Articles
J Cell Sci (2015) 128 (18): 3502–3513.
Published: 15 September 2015
...Hadi Khalil; Noureddine Loukili; Alexandre Regamey; Alvaro Cuesta-Marban; Elettra Santori; Marcel Huber; Christian Widmann ABSTRACT The nuclear factor κB (NF-κB) transcription factor is a master regulator of inflammation. Short-term NF-κB activation is generally beneficial. However, sustained NF-κB...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3055–3067.
Published: 15 August 2015
... transcriptional program and inhibits an erythroid transcriptional program. DLX4 also induced gene signatures that are associated with nuclear factor κB (NF-κB) signaling. The ability of DLX4 to promote megakaryocyte development at the expense of erythroid generation was diminished by blocking NF-κB activity or by...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2430–2436.
Published: 15 July 2015
...Bin Ma; Monika Fey; Michael O. Hottiger ABSTRACT The discovery of functional crosstalk between WNT and nuclear factor κB (NF-κB) signaling has established a more complex role for these two pathways in inflammation and cancer. However, the molecular mechanisms of the crosstalk and its biological...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1507–1517.
Published: 15 April 2015
... for correspondence ( carlos.ibanez@ki.se ) Competing interests The authors declare no competing or financial interests. 14 8 2014 16 2 2015 © 2015. Published by The Company of Biologists Ltd 2015 Cell death γ‐secretase Nerve growth factor NFκB Presenilin‐1...
Journal Articles
J Cell Sci (2015) 128 (2): 373–384.
Published: 15 January 2015
... nuclear factor κB (NF-κB) pathway were identified, including the p50 and p65 (RelA) NF-κB subunits. We show that FAM21 interacts with these components and regulates NF-κB-dependent gene transcription at the level of p65 chromatin binding. We further demonstrate that FAM21 contains a functional monopartite...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4645–4657.
Published: 01 November 2014
... factor NF-κB. The epigenetic mechanism underlying LPS-induced pro-inflammatory transcription is not fully understood. Herein, we describe a role for myocardin-related transcription factor A (MRTF-A, also known as MKL1) in this process. MRTF-A overexpression enhanced NF-κB-dependent pro-inflammatory...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3659–3665.
Published: 01 September 2014
...Andrew O'Hara; James Simpson; Pierre Morin; Carolyn J. Loveridge; Ann C. Williams; Sonia M. Novo; Lesley A. Stark ABSTRACT Nucleolar sequestration of the RelA subunit of nuclear factor (NF)-κB is an important mechanism for regulating NF-κB transcriptional activity. Ubiquitylation, facilitated by...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3257–3268.
Published: 01 August 2014
...-surface receptor of S5a has not been identified. In this study, we show that apoptotic THP-1 cells release endogenous S5a that binds to death receptor-6 (DR6, also known as TNFRSF1), which was identified as an orphan receptor, to induce THP-1 cells to differentiate. Furthermore, we found that the NF-κB...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (14): 3052–3065.
Published: 15 July 2014
...Ronny Haenold; Falk Weih; Karl-Heinz Herrmann; Karl-Friedrich Schmidt; Katja Krempler; Christian Engelmann; Klaus-Armin Nave; Jürgen R. Reichenbach; Sigrid Löwel; Otto W. Witte; Alexandra Kretz ABSTRACT NF-κB is dually involved in neurogenesis and brain pathology. Here, we addressed its role in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2383–2390.
Published: 01 June 2014
... competing interests. © 2014. Published by The Company of Biologists Ltd 2014 CREB MyD88 NF-κB Toll-like receptor Inflammation Interleukin The interaction of components of bacterial and viral pathogens with Toll-like receptors (TLRs), or the activation of the receptors for interleukin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 3862–3872.
Published: 01 September 2013
... laboratory fish species Japanese medaka. Here, pigment cells are transformed by an oncogenic receptor tyrosine kinase in fish expressing GFP throughout their vasculature. We show that angiogenesis occurs in a reactive oxygen species (ROS)- and NF-κB-dependent, but hypoxia-independent manner. Intriguingly, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 4037–4047.
Published: 01 September 2013
... was subsequently translocated to the nucleus as a p50/p50 homodimer. Knockdown of NF-κB p50 abolished the ability of RvD1 to suppress TNF-α expression and also to restore efferocytosis, suggesting that the replacement of p65/p50 with p50/p50 homodimer in the nucleus is crucial for RvD1-mediated...
Includes: Supplementary data