... bodies (PML-NBs, also known as ND10) contribute to host restriction of herpes simplex virus type 1 (HSV-1) replication via mechanisms that are counteracted by viral regulatory protein ICP0. ND10 assembly is dependent on PML, which comprises several different isoforms, and depletion of all PML isoforms...

...Alexander M. Ishov; Olga V. Vladimirova; Gerd G. Maul Placing regulatory proteins into different multiprotein complexes should modify key cellular processes. Here, we show that the transcription repressor Daxx and the SWI/SNF protein ATRX are both associated with two intranuclear domains: ND10/PML...

...Isabelle Nefkens; Dmitri G. Negorev; Alexander M. Ishov; Jennifer S. Michaelson; Edward T. H. Yeh; Robert M. Tanguay; Werner E. G. Müller; Gerd G. Maul Nuclear domains called ND10 or PML bodies might function as nuclear depots by recruiting or releasing certain proteins. Although recruitment...

...Roger D. Everett; Patrick Lomonte; Thomas Sternsdorf; Roel van Driel; Anne Orr ABSTRACT The nuclear sub-structures known as ND10, PODs or PML nuclear bodies can be rapidly modified by diverse stimuli, and the resultant structural changes correlate with events such as cellular transformation...

...Roger D. Everett; William C. Earnshaw; Ann F. Pluta; Thomas Sternsdorf; Alexandra M. Ainsztein; Mar Carmena; Sandrine Ruchaud; Wei-Li Hsu; Anne Orr ABSTRACT ND10, otherwise known as nuclear dots, PML nuclear bodies or PODs, are punctate foci in interphase nuclei that contain several cellular...