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Keywords: NADPH oxidase
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Journal Articles
J Cell Sci (2014) 127 (11): 2589–2600.
Published: 1 June 2014
...-dependent NADPH oxidase activity, suggesting they both function upstream of Rac in this system. Loss of RhoG also impaired GPCR-driven recruitment of the Rac GEF DOCK2, and F-actin, to the leading edge of migrating neutrophils. Taken together, our results reveal a new signalling hierarchy in which P-Rex1...
Journal Articles
J Cell Sci (2012) 125 (4): 956–964.
Published: 15 February 2012
... that it promotes angiogenic responses in endothelial cells, although the underlying signalling mechanisms are unclear. Reactive oxygen species derived from NADPH oxidases are major signalling molecules in the vasculature. Because NOX2 is functional in endothelial cells, we investigated the role of the NOX2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (8): 1238–1247.
Published: 15 April 2009
...Sylvia Luxen; Deborah Noack; Monika Frausto; Suzel Davanture; Bruce E. Torbett; Ulla G. Knaus Duox NADPH oxidases generate hydrogen peroxide at the air-liquid interface of the respiratory tract and at apical membranes of thyroid follicular cells. Inactivating mutations of Duox2 have been linked...
Includes: Multimedia, Supplementary data
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J Cell Sci (2002) 115 (6): 1099–1105.
Published: 15 March 2002
... of the neutrophil oxidase complex. * Author for correspondence (e-mail: chris.ellson@bbsrc.ac.uk ) © The Company of Biologists Limited 2002 2002 Phox PI3-kinase PtdIns(3) P Trafficking NADPH oxidase SNX Phosphoinositide levels are exquisitely regulated within cells and constitute...
Journal Articles
J Cell Sci (1999) 112 (4): 503–513.
Published: 15 February 1999
... NADPH oxidase. Truncated constructs of p40phox and Ku70 were used to map the interacting sites. The 186 C-terminal amino acids (aa) of Ku70 were found to interact with two distinct regions of p40phox, the central core region (aa 50-260) and the C-terminal extremity (aa 260-339). In complementary...
Journal Articles
J Cell Sci (1998) 111 (1): 81–91.
Published: 1 January 1998
... Neutrophil NADPH oxidase Phorbol myristate acetate Superoxide Human neutrophils play an essential role in host defense against infection. An important part of this defense is the generation of superoxide (O 2 − ) and its reactive derivatives (i.e. hydrogen peroxide, hydroxyl radical, and singlet...
Journal Articles
J Cell Sci (1997) 110 (24): 3071–3081.
Published: 15 December 1997
...Ann Grogan; Emer Reeves; Nicholas Keep; Frans Wientjes; Nicholas F. Totty; Alma L. Burlingame; J. Justin Hsuan; Anthony W. Segal ABSTRACT The NADPH oxidase generates microbicidal superoxide in phagocytes, and when defective it leads to chronic granu-lomatous disease (CGD). Oxidase specific proteins...
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