... that it probably targets acidic organelles. Lysosomes Ca 2+ NAADP Two-pore channels Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 BB/N01524X/1, BB/T015853/1 Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659...

..., pharmacological inhibition of TPC regulators [Rab7, NAADP and PtdIns(3,5) P 2 ] and buffering local Ca 2+ increases. NAADP-evoked Ca 2+ signals were exaggerated in diseased cells. TPC2 is thus a potential drug target within a pathogenic LRRK2 cascade that disrupts Ca 2+ -dependent trafficking in Parkinson disease...

... messenger NAADP demonstrated that lysosome–ER microdomains are capable of driving global Ca 2+ oscillations. Interestingly, our simulations suggest that the microdomain [Ca 2+ ] need not be higher than that in the cytosol for responses to occur, thus matching the relatively high affinity of IP 3 receptors...

... membrane contact sites, and akin to the proposed mechanism of action of the Ca 2+ mobilising messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Our data identify functional and physical association of discrete Ca 2+ stores important for the genesis of Ca 2+ signal complexity. GPN-evoked Ca...

... that the NPCs are open even after depletion of the Ca 2+ store in the nuclear envelope. Other research has suggested that a new Ca 2+ -releasing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP), can liberate Ca 2+ only from acidic organelles, probably lysosomes, rather than from the traditional...

... and the mechanisms of how these internal stores are mobilized are largely unknown. In this study, we describe two Ca 2+ stores, one of which is regulated by cyclic ADP-ribose (cADPR) and the other by nicotinic acid adenine dinucleotide phosphate (NAADP). We took advantage of the large size of the sea urchin egg...