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Keywords: N-WASp
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (15): jcs260364.
Published: 16 August 2022
... and in 2D, whereas a seminal study on epithelial tumor cell migration in 3D has already uncovered mutual antagonisms between classical, WRC–Arp2/3-dependent migration and N-WASP–Arp2/3-dependent tissue invasion ( Tang et al., 2013 ). Our studies using CRISPR/Cas9-mediated gene editing in various...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (24): jcs232355.
Published: 13 December 2019
... the fission of transport carriers from the TGN. Phosphorylation of cortactin at S298 impairs the interaction between WIP (also known as WIPF1) and cortactin. WIP stabilizes the autoinhibited conformation of N-WASP (also known as WASL). This leads to an inhibition of synergistic Arp2/3-complex-dependent actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2235–2241.
Published: 15 July 2017
...: This article provides insight into new functions of WASP family proteins from regulating the biogenesis of autophagosomes to recently identified roles in the nucleus. WASP N-WASP WAVE WHAMM WASH JMY WHAMY Arp2/3 Actin Actin monomers are dynamically incorporated into filamentous actin (F...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (3): 673–685.
Published: 1 February 2014
... of a signalling network consisting of Grb2, Nck, WIP and N-WASP. Nck is a potent activator of N-WASP–Arp2/3-dependent actin polymerisation. However, recent observations demonstrate that an interaction between Nck and N-WASP is not required for vaccinia actin tail formation. We found that Cdc42 cooperates with Nck...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2825–2830.
Published: 15 June 2012
... in response to FcγR ligation is mediated by the phosphorylation of tyrosine 282 and 298 in the ITAM motif in the cytoplasmic tail of the receptor. In the absence of FcγR phosphorylation, there is also no recruitment of N-WASP or Cdc42 to phagocytic cups. Nck promotes FcγR-mediated phagocytosis by recruiting N...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2011) 124 (12): 2001–2012.
Published: 15 June 2011
... execute CME remains unknown. Here, we show that neural Wiskott–Aldrich syndrome protein (N-WASP) and casein kinase 2 (CK2) form a complex and localize to clathrin-coated vesicles. N-WASP binds to and is phosphorylated by CK2, thereby reducing the kinase activity of CK2. By contrast, N-WASP-promoted actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (8): 1306–1319.
Published: 15 April 2010
... RTKs. Gab1 associates constitutively with the actin-nucleating factor N-WASP. Following RTK activation, Gab1 recruits Nck, an activator of N-WASP, into a signalling complex localised to dorsal ruffles. Formation of dorsal ruffles requires interaction between Gab1 and Nck, and also requires functional N...
Includes: Multimedia, Supplementary data
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J Cell Sci (2009) 122 (1): 5–11.
Published: 1 January 2009
... become clear that SNX9 has the ability to activate the actin regulator N-WASP in a membrane-dependent manner to coordinate actin polymerization with vesicle release. In this Commentary, we summarize several aspects of SNX9 structure and function in the context of membrane remodeling, discuss its...
Journal Articles
Journal Articles
J Cell Sci (2007) 120 (4): 658–669.
Published: 15 February 2007
..., FGFR1. Stimulation of serum-starved MDBK cells with FGF2 promoted IQGAP1-dependent lamellipodial protrusion and cell migration, and intracellular associations of IQGAP1 with FGFR1 – and two other factors – the Arp2/3 complex and its activator N-WASP, that coordinately promote nucleation of branched...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (21): 5059–5069.
Published: 1 November 2005
... promoting factor N-WASP by means of its SH3 domain, which also represents the docking site for eNOS. Via a coiled-coil region in the C-terminal portion of the protein, NOSTRIN oligomerizes, mainly forming trimers, which would allow simultaneous interaction with multiple binding partners of the SH3 domain...
Journal Articles
J Cell Sci (2005) 118 (14): 3103–3115.
Published: 15 July 2005
... the formation of protrusions such as lamellipodia and membrane ruffles, vertebrate cell functions of WASP or N-WASP are less well established. Recent work demonstrated that clathrin-coated pit invagination can coincide with assembly of actin filaments and with accumulation of N-WASP and Arp2/3 complex...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (1): 79–87.
Published: 1 January 2005
... domain, a regulator of the Arp2/3 complex, neural Wiskott Aldrich Syndrome protein (N-WASP). This in vitro activation of N-WASP is likely to be important in vivo, as cortactin-enhanced migration is dependent upon N-WASP. Thus, our results suggest that cortactin has multiple mechanisms by which it can...
Journal Articles
Journal Articles