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Keywords: N-WASP
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Journal Articles
J Cell Sci (2019) 132 (24): jcs232355.
Published: 13 December 2019
... the fission of transport carriers from the TGN. Phosphorylation of cortactin at S298 impairs the interaction between WIP (also known as WIPF1) and cortactin. WIP stabilizes the autoinhibited conformation of N-WASP (also known as WASL). This leads to an inhibition of synergistic Arp2/3-complex-dependent actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2235–2241.
Published: 15 July 2017
... Rohatgi , R. , Ho , H.-Y. H. and Kirschner , M. W. ( 2000 ). Mechanism of N-Wasp activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate . J. Cell Biol.   150 , 1299 - 1310 . 10.1083/jcb.150.6.1299 Ropers , F. , Derivery , E. , Hu , H. , Garshasbi , M...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (3): 673–685.
Published: 01 February 2014
... of a signalling network consisting of Grb2, Nck, WIP and N-WASP. Nck is a potent activator of N-WASP–Arp2/3-dependent actin polymerisation. However, recent observations demonstrate that an interaction between Nck and N-WASP is not required for vaccinia actin tail formation. We found that Cdc42 cooperates with Nck...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2825–2830.
Published: 15 June 2012
... in response to FcγR ligation is mediated by the phosphorylation of tyrosine 282 and 298 in the ITAM motif in the cytoplasmic tail of the receptor. In the absence of FcγR phosphorylation, there is also no recruitment of N-WASP or Cdc42 to phagocytic cups. Nck promotes FcγR-mediated phagocytosis by recruiting N...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (3): 724–734.
Published: 01 February 2012
... to have roles in cancer invasion and metastasis, direct evidence has not been available. We previously reported that neural Wiskott–Aldrich syndrome protein (N-WASP), a member of WASP family proteins that regulate reorganization of the actin cytoskeleton, is an essential component of invadopodia. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 67–80.
Published: 01 January 2012
...Joongkyu Park; Jee Young Sung; Joohyun Park; Woo-Joo Song; Sunghoe Chang; Kwang Chul Chung Neural Wiskott–Aldrich syndrome protein (N-WASP) is involved in tight regulation of actin polymerization and dynamics. N-WASP activity is regulated by intramolecular interaction, binding to small GTPases...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 2001–2012.
Published: 15 June 2011
... execute CME remains unknown. Here, we show that neural Wiskott–Aldrich syndrome protein (N-WASP) and casein kinase 2 (CK2) form a complex and localize to clathrin-coated vesicles. N-WASP binds to and is phosphorylated by CK2, thereby reducing the kinase activity of CK2. By contrast, N-WASP-promoted actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (8): 1306–1319.
Published: 15 April 2010
... RTKs. Gab1 associates constitutively with the actin-nucleating factor N-WASP. Following RTK activation, Gab1 recruits Nck, an activator of N-WASP, into a signalling complex localised to dorsal ruffles. Formation of dorsal ruffles requires interaction between Gab1 and Nck, and also requires functional N...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (1): 128–140.
Published: 01 January 2010
...Tine Lefever; Esben Pedersen; Astrid Basse; Ralf Paus; Fabio Quondamatteo; Alanna C. Stanley; Lutz Langbein; Xunwei Wu; Jürgen Wehland; Silvia Lommel; Cord Brakebusch N-WASP is a cytoplasmic molecule mediating Arp2/3 nucleated actin polymerization. Mice with a keratinocyte-specific deletion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (13): 2283–2291.
Published: 01 July 2009
... knockdown of CIP4 increased insulin-stimulated 14 C-deoxyglucose uptake by elevating cell-surface GLUT4. Enhanced surface GLUT4 was due to decreased endocytosis, which correlated with lower transferrin internalization. Immunoprecipitation of endogenous CIP4 revealed that CIP4 interacted with N-WASp...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (1): 5–11.
Published: 01 January 2009
... become clear that SNX9 has the ability to activate the actin regulator N-WASP in a membrane-dependent manner to coordinate actin polymerization with vesicle release. In this Commentary, we summarize several aspects of SNX9 structure and function in the context of membrane remodeling, discuss its...
Journal Articles
J Cell Sci (2007) 120 (15): 2694–2705.
Published: 01 August 2007
...Dagmar Pommereit; Fred S. Wouters NGF-induced differentiation of PC12 cells is mediated by actin-polymerisation-driven membrane protrusion, involving GTPase signalling pathways that activate actin nucleation promoting factors such as the neural Wiskott-Aldrich syndrome protein (N-WASP). Expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (4): 658–669.
Published: 15 February 2007
..., FGFR1. Stimulation of serum-starved MDBK cells with FGF2 promoted IQGAP1-dependent lamellipodial protrusion and cell migration, and intracellular associations of IQGAP1 with FGFR1 – and two other factors – the Arp2/3 complex and its activator N-WASP, that coordinately promote nucleation of branched...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (21): 5059–5069.
Published: 01 November 2005
... promoting factor N-WASP by means of its SH3 domain, which also represents the docking site for eNOS. Via a coiled-coil region in the C-terminal portion of the protein, NOSTRIN oligomerizes, mainly forming trimers, which would allow simultaneous interaction with multiple binding partners of the SH3 domain...
Journal Articles
J Cell Sci (2005) 118 (14): 3103–3115.
Published: 15 July 2005
... the formation of protrusions such as lamellipodia and membrane ruffles, vertebrate cell functions of WASP or N-WASP are less well established. Recent work demonstrated that clathrin-coated pit invagination can coincide with assembly of actin filaments and with accumulation of N-WASP and Arp2/3 complex...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (1): 79–87.
Published: 01 January 2005
... domain, a regulator of the Arp2/3 complex, neural Wiskott Aldrich Syndrome protein (N-WASP). This in vitro activation of N-WASP is likely to be important in vivo, as cortactin-enhanced migration is dependent upon N-WASP. Thus, our results suggest that cortactin has multiple mechanisms by which it can...
Journal Articles
J Cell Sci (2003) 116 (1): 155–168.
Published: 01 January 2003
... filaments. Furthermore, both Tc10 and RhoT induced neurite outgrowth in PC12 and N1E-115 cells, but Cdc42 did not do this by itself. Tc10 and RhoT as well as Cdc42 bound to the N-terminal CRIB-motif-containing portion of N-WASP and activated N-WASP to induce Arp2/3-complex-mediated actin polymerization...
Journal Articles
J Cell Sci (2001) 114 (24): 4533–4542.
Published: 15 December 2001
...-complex activating domain (VCA) of Wiskott-Aldrich syndrome proteins (WASP family proteins). We found that the branching of actin filaments on pre-existing ADP filaments mediated by the Arp2/3 complex is twice as efficient when Arp2/3 was activated by wild-type neural WASP (N-WASP) or WASP-family...