... and p50-NFκB. Furthermore, we show that p65-NFκB can modulate subcellular localization of the transcriptional corepressor N-CoR, abrogating N-CoR mediated repression of the Hes1 promoter. In addition, p65-NFκB is able to upregulate not only the Hes1 but also other promoters containing SRE and AP-1 sites...

...Kristen Jepsen; Michael G. Rosenfeld Transcriptional repression, which plays a crucial role in diverse biological processes, is mediated in part by non-DNA-binding co-repressors. The closely related co-repressor proteins N-CoR and SMRT, although originally identified on the basis of their ability...