... , R. and Bengtsson , T. ( 2008 ). Myotube formation on micro-patterned glass: intracellular organization and protein distribution in C2C12 skeletal muscle cells . J. Histochem. Cytochem.   56 , 881 - 892 . 10.1369/jhc.2008.951228 Yasuda , Y. , Miyamoto , Y. , Saiwaki , T...

...Aude Espigat-Georger; Vyacheslav Dyachuk; Cécile Chemin; Laurent Emorine; Andreas Merdes ABSTRACT Myotubes are syncytial cells generated by fusion of myoblasts. Among the numerous nuclei in myotubes of skeletal muscle fibres, the majority are equidistantly positioned at the periphery, except...

... how differentiation state couples to actomyosin-based contractility through adhesion and substrate compliance. Myotubes are differentiated from myoblasts on collagen-patterned coverslips that allow linear fusion but prevent classic myotube branching. Post-fusion, myotubes adhere to the micro-strips...

... but not -alpha1-mediated adhesion of human (Duchenne). and murine (mdx) dystrophic myotubes is seriously defective . FEBS Lett . 408 , 341 – 344 . 10.1016/S0014-5793(97)00460-2 Belkin , A. M. , Zhidkova , N. I. , Balzac , F. , Altruda , F. , Tomatis , D. , Maier...

... in differentiated cultures only, is characterised by reduced myotube size, myofibril disorganisation, loss of contractile activity, reduced spontaneous clustering of acetylcholine receptors and is reversed by addition of excess exogenous laminin-2. Thus, α-dystroglycan may be part of a signalling pathway...

...Takeshi Endo; Bernardo Nadal-Ginard ABSTRACT Terminally differentiated skeletal muscle myotubes are arrested in the Go phase of the cell cycle, and this arrest is not reversed by stimulation with serum or growth factors. The myotubes have been shown to be refractory to apoptosis even under low...

...Andre Menke; Harald Jockusch ABSTRACT A lack of the cytoskeletal protein dystrophin causes muscle fiber necrosis in Duchenne/Becker muscular dystrophies (DMD/BMD) and in murine X-linked muscular dystrophy (MDX). However, no overt disease symptoms are observed in dystrophin-less cultured myotubes...