... specialization in large multinucleated muscle cells. Myofiber Myotube Myonuclei cNLS core 10.13039/100006441 AR067645 National Institutes of Health 10.13039/100000002 AR062483 Skeletal muscle is crucial for survival and quality of life as it is required...

...Aude Espigat-Georger; Vyacheslav Dyachuk; Cécile Chemin; Laurent Emorine; Andreas Merdes ABSTRACT Myotubes are syncytial cells generated by fusion of myoblasts. Among the numerous nuclei in myotubes of skeletal muscle fibres, the majority are equidistantly positioned at the periphery, except...

... how differentiation state couples to actomyosin-based contractility through adhesion and substrate compliance. Myotubes are differentiated from myoblasts on collagen-patterned coverslips that allow linear fusion but prevent classic myotube branching. Post-fusion, myotubes adhere to the micro-strips...

... dystroglycan. * Author for correspondence ( discher seas.upenn.edu ) 08 03 1999 22 04 1999 © 1999 by Company of Biologists 1999 Myoblast Myotube Adhesion Micropattern Adherent cells typically display diversity not only in the types of their adhesion receptors, but also...

... in differentiated cultures only, is characterised by reduced myotube size, myofibril disorganisation, loss of contractile activity, reduced spontaneous clustering of acetylcholine receptors and is reversed by addition of excess exogenous laminin-2. Thus, α-dystroglycan may be part of a signalling pathway...

...Takeshi Endo; Bernardo Nadal-Ginard ABSTRACT Terminally differentiated skeletal muscle myotubes are arrested in the Go phase of the cell cycle, and this arrest is not reversed by stimulation with serum or growth factors. The myotubes have been shown to be refractory to apoptosis even under low...

...Andre Menke; Harald Jockusch ABSTRACT A lack of the cytoskeletal protein dystrophin causes muscle fiber necrosis in Duchenne/Becker muscular dystrophies (DMD/BMD) and in murine X-linked muscular dystrophy (MDX). However, no overt disease symptoms are observed in dystrophin-less cultured myotubes...