... to that of FGF2 and HGF, which both represent prototypical extracellular regulators of myogenesis. In addition, SDF1 inhibits myogenic differentiation in both C2C12 cells and primary myoblasts, as assessed by MyoD, myosin heavy chain and/or myogenin expression. Regarding signaling pathways, C2C12 cells responded...

... contracting avian muscle fibers. Furthermore, inhibition of IP3R1 activity by 2-aminoethoxydiphenylborate (2-APB) and xestospongin D induced a fiber type transition and expression of the slow myosin heavy chain 2 (slow MyHC2 ) gene in innervated fast muscle fibers. Activation of the slow MyHC2 promoter...

... (MA) muscles differentially control expression of the slow myosin heavy chain 2 (slow MyHC2 ) gene. We report here that slow MyHC2 gene expression in fast PM muscle fibers is repressed by endogenous activity of the ryanodine receptor 1 (RyR1). Inhibition of RyR1 with ryanodine led to expression...

...Torah Kachur; Wanyuan Ao; Jeffrey Berger; Dave Pilgrim The Caenorhabditis elegans UNC-45 protein contains tetratricopeptide repeats and a domain with similarity to fungal proteins, and it differentially colocalizes with myosin heavy chain B in the body wall muscles of adult worms. Although...

... of the myosin heavy chains, assumes a distribution that is analogous to that of endogenous myosin IIA, while the distribution of exogenously added brain myosin II, which is predominantly the B isoform, parallels that of endogenous myosin IIB. The differences between exogenously added myosins is important...

...Kin-Chow Chang; Kenneth Fernandes; Margaret J. Dauncey ABSTRACT Members of the myosin heavy chain (MyHC) gene family show developmental stage- and spatial-specificity of expression. We report on the characterization and identification of a porcine skeletal fast MyHC gene, including its...

...Kin-Chow Chang; Kenneth Fernandes; Geoffrey Goldspink ABSTRACT We report on the molecular characterization of the porcine slow-myosin heavy chain (HC) β gene and the isolation of its 5’ end cDNA. In vivo expression study, by in situ hybridization and histochemistry, revealed a highly regular...