... this issue and explore the cooperation of the two main components of a microvillus, the central F-actin bundle and the enveloping plasma membrane, we investigated the expression and function of Myosin VIIA (Myo7A), which is encoded by crinkled ( ck ), and its interaction with cadherin Cad99C...

...Raphaël Etournay; Ingrid Zwaenepoel; Isabelle Perfettini; Pierre Legrain; Christine Petit; Aziz El-Amraoui Defects in myosin VIIa lead to developmental anomalies of the auditory and visual sensory cells. We sought proteins interacting with the myosin VIIa tail by using the yeast two-hybrid system...

...Aziz El-Amraoui; Christine Petit Defects in myosin VIIa, the PDZ-domain-containing protein harmonin, cadherin 23 and protocadherin 15 (two cadherins with large extracellular regions), and the putative scaffolding protein Sans underlie five genetic forms of Usher syndrome type I (USH1), the most...

..., PHR1, and found that this protein can also bind to the myosin VIIa tail. PHR1 is an integral membrane protein that contains a pleckstrin homology (PH) domain. Myosin 1c and myosin VIIa are two unconventional myosins present in the inner ear sensory cells. We showed that PHR1 immunoprecipitates...

...Daniel Gibbs; Sassan M. Azarian; Concepcion Lillo; Junko Kitamoto; Adriana E. Klomp; Karen P. Steel; Richard T. Libby; David S. Williams Myosin VIIa functions in the outer retina, and loss of this function causes human blindness in Usher syndrome type 1B (USH1B). In mice with mutant Myo7a...

...Igor P. Udovichenko; Daniel Gibbs; David S. Williams Myosin VIIa has critical roles in the inner ear and the retina. To help understand how this protein functions, native myosin VIIa was tested for mechanoenzymatic properties. Myosin VIIa was immunoprecipitated from retinal tissue and found...