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Keywords: Myosin
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Journal Articles
In collection:
Cytoskeleton , Polarity
J Cell Sci (2022) 135 (3): jcs258921.
Published: 8 February 2022
... control ring assembly, but their contribution in different cell types is not known. We found that in the Caenorhabditis elegans embryo, AB and P 1 cells fated to be somatic tissue and germline, respectively, have different cytokinesis kinetics supported by distinct myosin levels and organization. Through...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (21): jcs258973.
Published: 5 November 2021
...Anja Schmidt; Long Li; Zhiyi Lv; Shuling Yan; Jörg Großhans ABSTRACT Rho signaling with its major targets the formin Dia, Rho kinase (Rok) and non-muscle myosin II (MyoII, encoded by zip in flies) control turnover, amount and contractility of actomyosin. Much less investigated has been a potential...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (16): jcs258602.
Published: 27 August 2021
... microclusters via these linkages. We show that contractile myosin filaments surround and are co-transported with SLP-76 microclusters, and that TCR ligand density governs the centripetal movement of both structures. Centripetal transport requires formin activity, actomyosin contraction, microtubule integrity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (10): jcs255844.
Published: 20 May 2021
...Katarzyna Majstrowicz; Ulrike Honnert; Petra Nikolaus; Vera Schwarz; Stefanie J. Oeding; Sandra A. Hemkemeyer; Martin Bähler ABSTRACT Myosin XIX (Myo19) is an actin-based motor that competes with adaptors of microtubule-based motors for binding to the outer mitochondrial transmembrane proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (7): jcs226084.
Published: 13 April 2021
... with mitochondria – the actin-based myosins, as well as the microtubule-based kinesins and dynein. In addition, Miro and TRAK proteins act as adaptors that link kinesin-1 and dynein, as well as myosin of class XIX (MYO19), to mitochondria and coordinate microtubule- and actin-based motor activities. Here, we...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2021) 134 (2): jcs249078.
Published: 27 January 2021
... the reduction in myosin activity normally seen in the later stage of junction formation. The aberrant myosin activation and impairments in closed junction formation in PLEKHG4B-knockdown cells were reverted by ROCK inhibition or LARG/PDZ-RhoGEF knockdown. These results suggest that PLEKHG4B enables actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs252965.
Published: 10 November 2020
...Stefano Sechi; Anna Frappaolo; Angela Karimpour-Ghahnavieh; Roberta Fraschini; Maria Grazia Giansanti ABSTRACT In animal cell cytokinesis, interaction of non-muscle myosin II (NMII) with F-actin provides the dominant force for pinching the mother cell into two daughters. Here we demonstrate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs242420.
Published: 4 June 2020
...Alexander W. Cook; Rosemarie E. Gough; Christopher P. Toseland ABSTRACT The myosin family of molecular motors are well-characterised cytoskeletal proteins. However, myosins are also present in the nucleus, where they have been shown to have roles in transcription, DNA repair and viral infections...
Journal Articles
J Cell Sci (2020) 133 (8): jcs238964.
Published: 28 April 2020
... ) and podosome mechanosensing ( Cervero et al., 2018 ). Accordingly, myosin IIA (also known as MYH9), the predominant myosin II isoform expressed in macrophages ( Maupin et al., 1994 ), is closely associated with podosomes. In particular, it is part of the lateral actomyosin cables that previously have been...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs230177.
Published: 22 August 2019
... these clusters. Interestingly, synaptopodin at the shaft-associated clusters is less dynamic than at spinous clusters. We identify the actin-based motor proteins myosin V (herein referring to both the myosin Va and Vb forms) and VI as novel interaction partners of synaptopodin, and demonstrate that myosin V...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs217422.
Published: 21 September 2018
... myosin activation enhances the internalization of FPR1 and C5aR1, thus reducing downstream signaling and impairing chemotaxis to primary chemoattractants. The polarized trafficking of chemoattractant GPCRs and its regulation by the BLT1-mediated myosin activation therefore drives persistent chemotactic...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2018) 131 (17): jcs219469.
Published: 10 September 2018
... are transported predominantly along microtubules by kinesin and dynein motors that bind indirectly via TRAK1 and TRAK2 to outer mitochondrial membrane proteins Miro1 and Miro2 (Miro1/2). Here, using proximity labelling, we identified Miro1/2 as potential binding partners of myosin XIX (Myo19). Interaction studies...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (12): jcs211334.
Published: 27 June 2018
... between the nascent adhesion complex and actin filament. Here, we show that myosin-1c is localized to the lateral membrane of polarized epithelial cells and facilitates the coupling between actin and cell–cell adhesion. Knockdown of myosin-1c compromised the integrity of the lateral membrane, reduced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs205955.
Published: 7 February 2018
...Hilary Renshaw; José M. Vargas-Muñiz; Praveen R. Juvvadi; Amber D. Richards; Greg Waitt; Erik J. Soderblom; M. Arthur Moseley; William J. Steinbach ABSTRACT Myosins are critical motor proteins that contribute to the secretory pathway, polarized growth, and cytokinesis. The globular tail domains...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs210310.
Published: 29 January 2018
... Blue light Chloroplast Chloroplast movement Myosin Phototropin The photorelocation movement of chloroplasts is one of the strategies that evolved to enable land plants to adapt to changing environmental light conditions. As plants are sessile organisms, they are unable to move away from...
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (15): 2530–2540.
Published: 1 August 2017
... showed defects in phagocytic cup formation, while lamellipodia were formed around IgG-Es. Because activated Rac1 reduced the phosphorylation levels of myosin light chains, failure of the cup formation is probably due to inhibition of actin/myosin II contractility. Reversible photo-manipulation...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (8): 1355–1363.
Published: 15 April 2017
... declare no competing or financial interests. © 2017. Published by The Company of Biologists Ltd 2017 Myosin is a key factor in the contractile forces that are generated through the actomyosin complex in many systems ( Sellers, 2000 ). Drosophila myosin II consists of the heavy chain Zipper...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 827–840.
Published: 1 March 2017
...Bennett J. Waxse; Prabuddha Sengupta; Geoffrey G. Hesketh; Jennifer Lippincott-Schwartz; Folma Buss ABSTRACT In this study, we demonstrate myosin VI enrichment at Cx43 (also known as GJA1)-containing gap junctions (GJs) in heart tissue, primary cardiomyocytes and cell culture models. In primary...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1179–1189.
Published: 15 March 2016
...Arnab Gupta; Michael J. Schell; Ashima Bhattacharjee; Svetlana Lutsenko; Ann L. Hubbard ABSTRACT The cellular machinery responsible for Cu + -stimulated delivery of the Wilson-disease-associated protein ATP7B to the apical domain of hepatocytes is poorly understood. We demonstrate that myosin Vb...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (20): 3707–3713.
Published: 15 October 2015
... signalling is poorly understood. Here, we show a new role for endocytosis in regulating the response to low phosphate in Schizosaccharomyces pombe . Loss of function of myosin I (Myo1), Sla2/End4 or Arp2, proteins involved in the early steps of endocytosis, led to increased proliferation in low-phosphate...
Includes: Supplementary data