...Tetsuaki Miyake; John C. McDermott ABSTRACT Myogenesis, the process of muscle differentiation, requires an extensive remodeling of the cellular transcriptome and proteome. Whereas the transcriptional program underpinning myogenesis is well characterized, the required adaptation in protein synthesis...

... with transforming growth factor-β (TGF-β)–Smad and Wnt/β-catenin pathways. Previously, we implicated Smad7 and β-catenin in mammalian myogenesis. Therefore, we assessed a potential role of TAZ on the Smad7–β-catenin complex in muscle cells. Here, we document functional interactions between Smad7, TAZ and β-catenin...

... Aminophospholipid translocase P4-ATPase Myogenesis Skeletal myoblasts Lundbeckfonden http://dx.doi.org/10.13039/501100003554 R221-2016-1005 Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 INST 213/886-1 FUGG Københavns Universitet http://dx.doi.org...

...Yen-Ling Lian; Kuan-Wei Chen; Yu-Ting Chou; Ting-Ling Ke; Bi-Chang Chen; Yu-Chun Lin; Linyi Chen ABSTRACT Myoblast fusion is required for myotube formation during myogenesis, and defects in myoblast differentiation and fusion have been implicated in a number of diseases, including human...

... with, those of the muscle stem cell master regulator, Pax7. Facioscapulohumeral muscular dystrophy DUX4 Myogenesis Homeodomain Pax3 Pax7 National Institute of Arthritis and Musculoskeletal and Skin Diseases 10.13039/100000069 AR055685 Muscular Dystrophy Association 10.13039...

... lead to increased integrin adhesion to the ECM, and consolidation of the muscle–tendon junction. Adhesion Myogenesis Muscle Myotendinous junction Integrin Extracellular matrix Chondroitin sulfate proteoglycan Perdido Kon-tiki NG2 CSPG4 Universidad Pablo de Olavide...

...Xingyu Zhou; Mingsen Li; Huaxing Huang; Keren Chen; Zhuning Yuan; Ying Zhang; Yaping Nie; Hu Chen,; Xumeng Zhang; Luxi Chen; Yaosheng Chen; Delin Mo ABSTRACT Although the mechanism underlying modulation of transcription factors in myogenesis has been well elucidated, the function...

...Stephanie Wales Tobin; Dabo Yang; John Girgis; Ali Farahzad; Alexandre Blais; John C. McDermott ABSTRACT Mycocyte enhancer factor 2 (MEF2) and activator protein 1 (AP-1) transcription complexes have been individually implicated in myogenesis, but their genetic interaction has not previously been...

... protein Kette is essential for myoblast fusion. It controls the dissolution of electron-dense plaques and the ratio of Scar and WASp proteins in fusion-competent myoblasts during fusion pore formation. Myogenesis Myoblast fusion WAVE F-actin Wip Vrp1 Cellular junction Deutsche...

... development, myoblasts and satellite cell proliferation and differentiation in vertebrates. We also outline the relationship between Notch, Wnt and growth factor signalling pathways, as well as the post-transcriptional regulation of myogenesis under conditions of hypoxia. * Authors for correspondence...

...Yan Huang; Bohong Chen; Miaoman Ye; Puping Liang; Yingnan Zhangfang; Junjiu Huang; Mingyao Liu; Zhou Songyang; Wenbin Ma ABSTRACT Skeletal myogenesis is a multistep process in which basic helix-loop-helix (bHLH) transcription factors, such as MyoD (also known as MyoD1), bind to E-boxes and activate...

...Demetris Koutalianos; Andrie Koutsoulidou; Nikilaos P. Mastroyiannopoulos; Denis Furling; Leonidas A. Phylactou ABSTRACT Twist-1 is mostly expressed during development and has been previously shown to control myogenesis. Because its regulation in muscle has not been fully exploited, the aim...

... that Bit‐1 controls skeletal myogenesis through a caspase‐mediated signaling pathway. Bit‐1 ‐null mice exhibit a myopathy with hypotrophic myofibers. Bit‐1 ‐null myoblasts prematurely express muscle‐specific proteins. Similarly, knockdown of Bit‐1 expression in C2C12 myoblasts promotes early...

..., France. ‡ Author for correspondence ( [email protected] ) Competing interests The authors declare no competing interests. 22 02 2014 18 08 2014 © 2014. Published by The Company of Biologists Ltd 2014 Notch Reck Talin Trio Gene regulation Myogenesis Drosophila...

... under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Muscle regeneration Myogenesis Matn2 shRNA TGF-β...

...) in myofibrillogenesis. Expression of perd RNAi in muscles, prior to adult myogenesis, can induce misorientation and detachment of Drosophila adult abdominal muscles. In comparison to controls, perd -depleted muscles contain fewer myofibrils, which are localized at the cell periphery. These myofibrils are detached from...

...Jenean H. O'Brien; Laura Hernandez-Lagunas; Kristin Bruk Artinger; Heide L. Ford ABSTRACT Precise spatiotemporal regulation of the SIX1 homeoprotein is required to coordinate vital tissue development, including myogenesis. Whereas SIX1 is downregulated in most tissues following embryogenesis...

... inside the myofiber. We thus concluded that inhibition of satellite cells fusion in vivo blocks their proliferation and potentially their differentiation. We have explored the mechanisms of myogenesis in neonatal mouse and Xenopus tadpoles. We found that mouse myogenic cells interact...

...Fabrice Antigny; Stéphane Koenig; Laurent Bernheim; Maud Frieden Summary Myogenesis involves expression of muscle-specific transcription factors such as myogenin and myocyte enhancer factor 2 (MEF2), and is essentially regulated by fluctuations of cytosolic Ca 2+ concentration. Recently we...

... 1 (Bmal1), an essential transcriptional activator of the clock, is highly expressed in skeletal muscle. However, whether this key clock component impacts myogenesis, a temporally regulated event that requires the sequential activation of myogenic regulatory factors, is not known. Here we report...