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1-16 of 16
Keywords: Myofibroblast
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Journal Articles
Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro–adipogenic progenitors
Available to PurchaseOsvaldo Contreras, Meilyn Cruz-Soca, Marine Theret, Hesham Soliman, Lin Wei Tung, Elena Groppa, Fabio M. Rossi, Enrique Brandan
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (19): jcs232157.
Published: 9 October 2019
... PDGFRα expression in FAPs, mouse dermal fibroblasts and in two related mesenchymal cell lines. Moreover, TGF-β promotes myofibroblast differentiation of FAPs but inhibits their adipogenicity. Accordingly, TGF-β impairs the expression of PDGFRα-dependent immediate early genes in a TGFBR1-dependent manner...
Includes: Supplementary data
Journal Articles
Hypoxia suppresses myofibroblast differentiation by changing RhoA activity
Available to PurchaseLisa Leinhos, Johannes Peters, Sabine Krull, Lena Helbig, Melanie Vogler, Magdolna Levay, Gijsbert J. van Belle, Anne J. Ridley, Susanne Lutz, Dörthe M. Katschinski, Anke Zieseniss
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (5): jcs223230.
Published: 18 February 2019
...Lisa Leinhos; Johannes Peters; Sabine Krull; Lena Helbig; Melanie Vogler; Magdolna Levay; Gijsbert J. van Belle; Anne J. Ridley; Susanne Lutz; Dörthe M. Katschinski; Anke Zieseniss ABSTRACT Fibroblasts show a high range of phenotypic plasticity, including transdifferentiation into myofibroblasts...
Includes: Supplementary data
Journal Articles
The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix
Available to PurchaseFranco Klingberg, Grace Chau, Marielle Walraven, Stellar Boo, Anne Koehler, Melissa L. Chow, Abby L. Olsen, Michelle Im, Monika Lodyga, Rebecca G. Wells, Eric S. White, Boris Hinz
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (5): jcs201293.
Published: 1 March 2018
...Franco Klingberg; Grace Chau; Marielle Walraven; Stellar Boo; Anne Koehler; Melissa L. Chow; Abby L. Olsen; Michelle Im; Monika Lodyga; Rebecca G. Wells; Eric S. White; Boris Hinz ABSTRACT Dysregulated secretion and extracellular activation of TGF-β1 stimulates myofibroblasts to accumulate...
Journal Articles
The deubiquitylase USP10 regulates integrin β1 and β5 and fibrotic wound healing
Available to PurchaseIn collection:
Adhesion
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (20): 3481–3495.
Published: 15 October 2017
...Stephanie R. Gillespie; Liana J. Tedesco; Lingyan Wang; Audrey M. Bernstein ABSTRACT Scarring and fibrotic disease result from the persistence of myofibroblasts characterized by high surface expression of αv integrins and subsequent activation of the transforming growth factor β (TGFβ) proteins...
Includes: Supplementary data
Journal Articles
Scott D. Varney, Courtney B. Betts, Rui Zheng, Lei Wu, Boris Hinz, Jiliang Zhou, Livingston Van De Water
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (4): 774–787.
Published: 15 February 2016
...Scott D. Varney; Courtney B. Betts; Rui Zheng; Lei Wu; Boris Hinz; Jiliang Zhou; Livingston Van De Water ABSTRACT How mechanical cues from the extracellular environment are translated biochemically to modulate the effects of TGF-β on myofibroblast differentiation remains a crucial area...
Includes: Supplementary data
Journal Articles
Mechanobiology of myofibroblast adhesion in fibrotic cardiac disease
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (10): 1865–1875.
Published: 15 May 2015
... and extracellular matrix composition. Cadherins mechanically link neighboring cells and are likely to contribute to fibrotic disease propagation. Finally, transition to the active myofibroblast phenotype leads to maladaptive tissue remodeling and enhanced mechanotransductive signaling, forming a positive feedback...
Journal Articles
Sharp-1 regulates TGF-β signaling and skeletal muscle regeneration
Available to PurchaseSujata Acharjee, Teng-Kai Chung, Suma Gopinadhan, Shilpa Rani Shankar, Yaju Wang, Li Li, Cecile Vercherat, Neriman Tuba Gulbagci, Moritz Rossner, Reshma Taneja
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (3): 599–608.
Published: 1 February 2014
... −/− injured muscles. In vitro , Sharp-1 associates with Smad3, and its overexpression inhibits TGF-β- and Smad3-mediated expression of extracellular matrix genes in myofibroblasts. These results demonstrate that Sharp-1 regulates muscle regenerative capacity, at least in part, by modulation of TGF-β signaling...
Journal Articles
Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair
Available to PurchaseChristopher G. Elliott, Jian Wang, Xiaolei Guo, Shi-wen Xu, Mark Eastwood, Jianjun Guan, Andrew Leask, Simon J. Conway, Douglas W. Hamilton
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (1): 121–132.
Published: 1 January 2012
... of periostin, day 7 wounds showed a significant reduction in myofibroblasts, as visualized by expression of α-smooth muscle actin (α-SMA) within the granulation tissue. Delivery of recombinant human periostin by electrospun collagen scaffolds restored α-SMA expression. Isolated wild-type and knockout dermal...
Includes: Supplementary data
Journal Articles
Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts – role of TGFβ1 levels and RhoA activity
Available to PurchaseKatrin Blumbach, Manon C. Zweers, Georg Brunner, Andreas S. Peters, Markus Schmitz, Jan-Niklas Schulz, Alexander Schild, Christopher P. Denton, Takao Sakai, Reinhard Fässler, Thomas Krieg, Beate Eckes
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (22): 3872–3883.
Published: 15 November 2010
... due to a severe reduction in the number of myofibroblasts, whereas inflammatory infiltrate and vascularization of the granulation tissue are unaffected. Primary ILK-deficient fibroblasts exhibit severely reduced levels of extracellular TGFβ1, α-smooth muscle actin (αSMA) production and myofibroblast...
Includes: Supplementary data
Journal Articles
Expression of integrin β1 by fibroblasts is required for tissue repair in vivo
Available to PurchaseShangxi Liu, Xu Shi-wen, Katrin Blumbach, Mark Eastwood, Christopher P. Denton, Beate Eckes, Thomas Krieg, David J. Abraham, Andrew Leask
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (21): 3674–3682.
Published: 1 November 2010
... actin (α-SMA). Integrin-β1-deficient fibroblasts showed reduced expression of type I collagen and connective tissue growth factor, and failed to differentiate into myofibroblasts as a result of reduced α-SMA stress fiber formation. Loss of integrin β1 in adult fibroblasts reduced their ability to adhere...
Journal Articles
A new lock-step mechanism of matrix remodelling based on subcellular contractile events
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (10): 1751–1760.
Published: 15 May 2010
...Lysianne Follonier Castella; Lara Buscemi; Charles Godbout; Jean-Jacques Meister; Boris Hinz Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, [Ca 2+ ] i , contribute to myofibroblast contraction...
Includes: Supplementary data
Journal Articles
Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (6): 877–886.
Published: 15 March 2008
... of tissue under remodeling. * Author for correspondence (e-mail: [email protected] ) 31 12 2007 © The Company of Biologists Limited 2008 2008 Fig. 8. Possible models for AJ reinforcement in differentiated myofibroblasts. In our experiments, the reinforcement of OB-cadherin bonds...
Includes: Supplementary data
Journal Articles
Actin stress fibres
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (20): 3491–3499.
Published: 15 October 2007
.... e-mails: [email protected] ; [email protected] 21 8 2007 © The Company of Biologists Limited 2007 2007 Stress fibre Stress fibre Rho GTPase Actin Contractility Cell migration Myofibroblast Myoepithelial We have known for over 50 years...
Journal Articles
Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species
Available to PurchaseBahar Cat, Dominik Stuhlmann, Holger Steinbrenner, Lirija Alili, Olaf Holtkötter, Helmut Sies, Peter Brenneisen
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (13): 2727–2738.
Published: 1 July 2006
...Bahar Cat; Dominik Stuhlmann; Holger Steinbrenner; Lirija Alili; Olaf Holtkötter; Helmut Sies; Peter Brenneisen Myofibroblasts, pivotal for tumor progression, populate the microecosystem of reactive stroma. Using an in vitro tumor-stroma model of skin carcinogenesis, we report here that tumor-cell...
Journal Articles
Impaired wound healing in embryonic and adult mice lacking vimentin
Available to PurchaseBeate Eckes, Emma Colucci- Guyon, Hans Smola, Sue Nodder, Charles Babinet, Thomas Krieg, Paul Martin
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (13): 2455–2462.
Published: 1 July 2000
... appearance of myofibroblasts at the wound site. Wounds made to vimentindeficient embryos also failed to heal during the 24 hour culture period it takes for wildtype embryos to fully heal an equivalent wound. By DiI marking the wound mesenchyme and following its fate during the healing process we showed...
Journal Articles
A functional knock-out of titin results in defective myofibril assembly
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (8): 1405–1414.
Published: 15 April 2000
.... The myofibroblast cell line BHK-21/C13 was described to assemble myofibrils in culture. We have now characterized the sub-line BHK-21-Bi, which bears a small deletion within the titin gene. RNA analysis revealed that in this mutant cell line only a small internal portion of the titin mRNA is deleted. However...