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Keywords: Myofibroblast
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Journal Articles
J Cell Sci (2019) 132 (19): jcs232157.
Published: 09 October 2019
... PDGFRα expression in FAPs, mouse dermal fibroblasts and in two related mesenchymal cell lines. Moreover, TGF-β promotes myofibroblast differentiation of FAPs but inhibits their adipogenicity. Accordingly, TGF-β impairs the expression of PDGFRα-dependent immediate early genes in a TGFBR1-dependent manner...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs223230.
Published: 18 February 2019
...Lisa Leinhos; Johannes Peters; Sabine Krull; Lena Helbig; Melanie Vogler; Magdolna Levay; Gijsbert J. van Belle; Anne J. Ridley; Susanne Lutz; Dörthe M. Katschinski; Anke Zieseniss ABSTRACT Fibroblasts show a high range of phenotypic plasticity, including transdifferentiation into myofibroblasts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (5): jcs201293.
Published: 01 March 2018
...Franco Klingberg; Grace Chau; Marielle Walraven; Stellar Boo; Anne Koehler; Melissa L. Chow; Abby L. Olsen; Michelle Im; Monika Lodyga; Rebecca G. Wells; Eric S. White; Boris Hinz ABSTRACT Dysregulated secretion and extracellular activation of TGF-β1 stimulates myofibroblasts to accumulate...
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (20): 3481–3495.
Published: 15 October 2017
...Stephanie R. Gillespie; Liana J. Tedesco; Lingyan Wang; Audrey M. Bernstein ABSTRACT Scarring and fibrotic disease result from the persistence of myofibroblasts characterized by high surface expression of αv integrins and subsequent activation of the transforming growth factor β (TGFβ) proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 774–787.
Published: 15 February 2016
...Scott D. Varney; Courtney B. Betts; Rui Zheng; Lei Wu; Boris Hinz; Jiliang Zhou; Livingston Van De Water ABSTRACT How mechanical cues from the extracellular environment are translated biochemically to modulate the effects of TGF-β on myofibroblast differentiation remains a crucial area...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1865–1875.
Published: 15 May 2015
... and extracellular matrix composition. Cadherins mechanically link neighboring cells and are likely to contribute to fibrotic disease propagation. Finally, transition to the active myofibroblast phenotype leads to maladaptive tissue remodeling and enhanced mechanotransductive signaling, forming a positive feedback...
Journal Articles
J Cell Sci (2014) 127 (3): 599–608.
Published: 01 February 2014
... −/− injured muscles. In vitro , Sharp-1 associates with Smad3, and its overexpression inhibits TGF-β- and Smad3-mediated expression of extracellular matrix genes in myofibroblasts. These results demonstrate that Sharp-1 regulates muscle regenerative capacity, at least in part, by modulation of TGF-β signaling...
Journal Articles
J Cell Sci (2012) 125 (1): 121–132.
Published: 01 January 2012
... of periostin, day 7 wounds showed a significant reduction in myofibroblasts, as visualized by expression of α-smooth muscle actin (α-SMA) within the granulation tissue. Delivery of recombinant human periostin by electrospun collagen scaffolds restored α-SMA expression. Isolated wild-type and knockout dermal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (22): 3872–3883.
Published: 15 November 2010
... due to a severe reduction in the number of myofibroblasts, whereas inflammatory infiltrate and vascularization of the granulation tissue are unaffected. Primary ILK-deficient fibroblasts exhibit severely reduced levels of extracellular TGFβ1, α-smooth muscle actin (αSMA) production and myofibroblast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (21): 3674–3682.
Published: 01 November 2010
... actin (α-SMA). Integrin-β1-deficient fibroblasts showed reduced expression of type I collagen and connective tissue growth factor, and failed to differentiate into myofibroblasts as a result of reduced α-SMA stress fiber formation. Loss of integrin β1 in adult fibroblasts reduced their ability to adhere...
Journal Articles
J Cell Sci (2010) 123 (10): 1751–1760.
Published: 15 May 2010
...Lysianne Follonier Castella; Lara Buscemi; Charles Godbout; Jean-Jacques Meister; Boris Hinz Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, [Ca 2+ ] i , contribute to myofibroblast contraction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (6): 877–886.
Published: 15 March 2008
... of tissue under remodeling. To test the significance of N- and OB-cadherin adhesion in living myofibroblasts, we measured the interaction strength between cells grown on coverslips in monolayer and AFM cantilever tips coated with 10 μg/ml cadherin:Fc dimers ( Fig. 1D ). After 2 seconds of contact time...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (20): 3491–3499.
Published: 15 October 2007
.... J. Cell Sci. 111 , 3323 -3332. Darby, I., Skalli, O. and Gabbiani, G. ( 1990 ). Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab. Invest. 63 , 21 -29. DePina, A. S. and Langford, G. M. ( 1999 ). Vesicle transport: the role...
Journal Articles
J Cell Sci (2006) 119 (13): 2727–2738.
Published: 01 July 2006
...Bahar Cat; Dominik Stuhlmann; Holger Steinbrenner; Lirija Alili; Olaf Holtkötter; Helmut Sies; Peter Brenneisen Myofibroblasts, pivotal for tumor progression, populate the microecosystem of reactive stroma. Using an in vitro tumor-stroma model of skin carcinogenesis, we report here that tumor-cell...