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1-15 of 15
Keywords: Myofibrillogenesis
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Journal Articles
Sibylle Molt, John B. Bührdel, Sergiy Yakovlev, Peter Schein, Zacharias Orfanos, Gregor Kirfel, Lilli Winter, Gerhard Wiche, Peter F. M. van der Ven, Wolfgang Rottbauer, Steffen Just, Alexey M. Belkin, Dieter O. Fürst
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (16): 3578–3592.
Published: 15 August 2014
... muscle Myofibrillogenesis Xin actin-binding repeat-containing protein Phosphoglucomutase XIRP1 Aciculin PGM5 The contractile apparatus of striated muscle is a complex macromolecular assembly that is optimized for directed movement. During its development, multiple individual protein...
Includes: Supplementary data
Journal Articles
Marjorie Coisy-Quivy, Olivia Touzet, Annick Bourret, Robert A. Hipskind, Jacques Mercier, Philippe Fort, Alexandre Philips
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (7): 947–956.
Published: 1 April 2009
..., and, given the phenotype of obscurin and TC10 disruption in striated muscle, we expect that some human skeletal myopathies arise from defects in obscuring-TC10 pathway. We recently demonstrated the role of TC10 in myofibrillogenesis in an ascidian model ( Coisy-Quivy et al., 2006 ). To explore its...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (20): 4322–4331.
Published: 15 October 2006
...-binding sites intact. ES cells were differentiated into cardiomyocytes, and myofibrillogenesis investigated by immunofluorescence microscopy. Surprisingly, deletion of one allele did not markedly affect differentiation into cardiomyocytes, suggesting that a single intact copy of the titin gene...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (15): 3175–3188.
Published: 1 July 2004
..., the intermediate filament proteins desmin and vimentin, and the sarcomeric M-line region. In contrast, other sarcomeric regions and dynamic microtubules remained unaffected. MURF-2 knock-down studies in skeletal myoblasts also delayed myoblast fusion and myofibrillogenesis. Furthermore, contractile activity...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (9): 1795–1805.
Published: 1 April 2004
... genetic system with which to study myofibrillogenesis in vivo . We show in this paper that neither sarcomeric myosin nor actin are required for myoblast fusion or the subsequent morphogenesis of muscle fibres, i.e. fibre morphogenesis does not depend on myofibrillogenesis. However, fibre formation...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (1): 105–114.
Published: 1 January 2004
... of Biologists Limited 2004 2004 Myofibrillogenesis Cardiomyocytes N-RAP Actin N-RAP is a ∼190 kDa actin binding LIM protein found in skeletal and cardiac muscle tissues ( Luo et al., 1997 ; Mohiddin et al., 2003 ). In addition to its N-terminal LIM domain, N-RAP contains 10 or 11 simple...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (23): 4811–4819.
Published: 1 December 2003
... for initiating or regulating myofibrillogenesis. We used a gene-targeting approach in cultured myoblasts to truncate the titin gene so that the kinase domain and other domains downstream of the kinase were not expressed. We recovered cells in which one allele was targeted. We found that these cells expressed...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (8): 1471–1479.
Published: 15 April 2003
...Yang Luo; Glenn L. Radice The strong coordinated contraction of heart muscle is dependent on the correct alignment and connection of the myofibrils across the plasma membrane. Previous studies indicate that N-cadherin is involved in cardiac myocyte adhesion and myofibrillogenesis. To investigate...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (8): 1405–1414.
Published: 15 April 2000
... and in the coordination of myofibrillogenesis. * Author for correspondence (e-mail: [email protected] ) 10 02 2000 21 03 2000 © 2000 by Company of Biologists 2000 Titin/connectin BHK-21C/13 cell Null mutation Myofibrillogenesis Myofibroblast Myosin assembly Titin (also...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1999) 112 (22): 4101–4112.
Published: 15 November 1999
[email protected] ) * These three authors contributed equally to this report 25 08 1999 11 03 1999 © 1999 by Company of Biologists 1999 Myofibrillogenesis MYC-tagged s-α-actinin GFP-tagged T-cap Titin Nebulin α-Actin Much is known about how in cell free systems two...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1999) 112 (10): 1529–1539.
Published: 15 May 1999
...Elisabeth Ehler; Barbara M. Rothen; Sibylle P. Hämmerle; Masatoshi Komiyama; Jean-Claude Perriard ABSTRACT Myofibrillogenesis in situ was investigated by confocal microscopy of immunofluorescently labelled whole mount preparations of early embryonic chicken heart rudiments. The time-course...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1996) 109 (8): 2089–2099.
Published: 1 August 1996
... Cardiomyocyte Myofibrillogenesis Confocal laser scanning microscopy Fig. 1. Single expression of mT-tagged MLC isoforms in NRC. Cells were stained with antimT, followed by FITC-anti-mouse IgG (a,c,e,g,i) and Rho-phalloidin (b,d,f,h,j). Each inset represents the marked area at higher magnification...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (2): 581–593.
Published: 1 February 1995
... binding protein actin myofibrillogenesis muscle cell phosphatidylinositol 4,5-bisphosphate (PIP 2 ) microinjection Multiple actin-regulatory proteins have been characterized as being profoundly involved in various cell functions by regulating the assembly and disassembly of actin (for review...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1994) 107 (3): 377–386.
Published: 1 March 1994
... 23 08 1993 03 12 1993 © 1994 by Company of Biologists 1994 in situ hybridization costamere myofibrillogenesis intermediate filaments mRNA Costameres are ribs of protein that contain vinculin and lie between the cell membrane and the Z line in some skeletal muscles...
Journal Articles
Peter F. M. van der Ven, Gert Schaart, Huib J. E. Croes, Paul H. K. Jap, Leo A. Ginsel, Frans C. S. Ramaekers
Journal:
Journal of Cell Science
J Cell Sci (1993) 106 (3): 749–759.
Published: 1 November 1993
... of in vitro human myofibrillogenesis. On the basis of our results we assume that titin aggregates are targeted to SFLS through IF. The association of titin with SFLS might be crucial for the unwinding of titin necessary for the assembly of sarcomeres and the first association of titin with other sarcomeric...