...Nicanor González Morales; Océane Marescal; Szilárd Szikora; Anja Katzemich; Tuana Correia-Mesquita; Péter Bíró; Miklos Erdelyi; József Mihály; Frieder Schöck ABSTRACT Myofibrils are long intracellular cables specific to muscles, composed mainly of actin and myosin filaments. The actin and myosin...

...Juan J. Pérez-Moreno; Marcus Bischoff; Maria D. Martín-Bermudo; Beatriz Estrada ABSTRACT Muscle differentiation requires the assembly of high-order structures called myofibrils, composed of sarcomeres. Even though the molecular organization of sarcomeres is well known, the mechanisms underlying...

...Kazumi Nomura; Kanako Ono; Shoichiro Ono Summary Assembly of contractile apparatuses in striated muscle requires precisely regulated reorganization of the actin cytoskeletal proteins into sarcomeric organization. Regulation of actin filament dynamics is one of the essential processes of myofibril...

...-45 acts post-translationally for proper myosin folding and maturation. * Author for correspondence ( [email protected] ) 21 10 2010 © 2011. 2011 Chaperone Drosophila Muscle Myofibril UNC-45 Myosins are molecular motors that function in cellular processes...

... elements, the myofibrils, has to take place. This disassembly occurs in two steps with Z-disk and thin (actin)-filament-associated proteins getting disassembled before disassembly of the M-bands and the thick (myosin) filaments happens. After cytokinesis reassembly of the myofibrillar proteins...

...Qun Wang; Carole L. Moncman; Donald A. Winkelmann We have investigated the functional impact on cardiac myofibril organization and myosin motor activity of point mutations associated with familial hypertrophic cardiomyopathies (FHC). Embryonic chicken cardiomyocytes were transfected with vectors...

...Shajia Lu; Stefanie L. Carroll; Amy H. Herrera; Bradford Ozanne; Robert Horowits N-RAP, a muscle-specific protein concentrated at myotendinous junctions in skeletal muscle and intercalated disks in cardiac muscle, has been implicated in myofibril assembly. To discover more about the role of N-RAP...

... in the organization of functional myofibrils. * Author for correspondence (e-mail: [email protected] ) © 1999 by Company of Biologists 1999 Actin β-Cytoplasmic actin Isoform Myofibril Thin filament Multiple isoforms of actin have been described in almost all eukaryotic...

... end capping protein, tropomodulin, has been shown to maintain the lengths of thin filaments in mature myofibrils. To determine whether tropomodulin might also be involved in thin filament assembly, we investigated the assembly of tropomodulin into myofibrils during differentiation of primary cultures...

..., which, in addition to the N-terminal truncation, contained a deletion of the catenin binding domain. In the case of the truncated N-cadherin at the N terminus, the sarcomeric structure of the myofibrils of ARC was also affected. Myofibrils were the most vulnerable cytoskeletal structures affected...

... these interactions. Two prominent linkages are at the myotendinous junction (MTJ), which resides at the ends of the cell and connects myofibrils to the tendon, and the costameres, which encircle the girth of the cell and connect the Z-disks to the sarcolemma. In this study we report that the α v integrin subunit...

... these interactions. Two prominent linkages are at the myotendinous junction (MTJ), which resides at the ends of the cell and connects myofibrils to the tendon, and the costameres, which encircle the girth of the cell and connect the Z-disks to the sarcolemma. In this study we report that the α v integrin subunit...

.... * Author for correspondence 24 03 1993 19 05 1993 © 1993 by Company of Biologists 1993 fibronectin type III domain immunoglobulin-C2 domain M-protein myofibril sarcomeric muscle The giant protein titin, sometimes also referred to as connectin, has an approximate...

...Blair T. Atherton; Monica M. Behnke ABSTRACT The composition and organization of myofibrils at extra-junctional membrane attachment sites in cultured neonatal rat cardiac muscle cells were analysed by immunofluorescence and electron microscopy. When myofibril terminals attached to the cell membrane...