...Alicia A. Cutler; Jennifer B. Jackson; Anita H. Corbett; Grace K. Pavlath ABSTRACT Skeletal muscle is primarily composed of large myofibers containing thousands of post-mitotic nuclei distributed throughout a common cytoplasm. Protein production and localization in specialized myofiber regions...

..., during which it mediates myoblast fusion. We isolated both damaged and intact myofibers from a mouse model of muscular dystrophy using laser-capture microdissection and found that the levels of myoferlin mRNA and protein were increased in damaged myofibers. To better define the components of the muscle...

... extended these studies to isolated myofibers. These constitute the minimum viable functional unit of the skeletal muscle, thus providing a close model of in vivo regeneration of muscle tissue. We show that LELI stimulates cell cycle entry and the accumulation of satellite cells around isolated single...

... glycoprotein indicated that the fibers were infected over their entire length at a virus dose of 10 9 /ml. When we infected the myofibers with the tsO45 mutant at 39°C, the viral glyco-protein appeared to be localised to the terminal cisternae of the sarcoplasmic reticulum. Upon shifting the cultures...