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Keywords: Myocyte Enhancer Factor-2
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Journal Articles

A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart

Junmei Ye, Miriam Llorian, Maria Cardona, Anthony Rongvaux, Rana S. Moubarak, Joan X. Comella, Rhonda Bassel-Duby, Richard A. Flavell, Eric N. Olson, Christopher W. J. Smith, Daniel Sanchis
Journal: Journal of Cell Science
J Cell Sci (2013) 126 (7): 1682–1691.
https://doi.org/10.1242/jcs.121384
Published: 1 April 2013
... of the above processes in vivo and in vitro results in coherent changes in the alternative splicing of genes encoding tropomyosin-1 (TPM1), tropomyosin-2 (TPM2) and myocyte enhancer factor-2 (MEF2). Thus, we report a pathway connecting HDAC, cFLIP and caspases regulating the progressive disappearance of PTB...
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Includes: Supplementary data