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Keywords: MyoD
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Journal Articles
J Cell Sci (2016) 129 (14): 2767–2777.
Published: 15 July 2016
...Yan Huang; Bohong Chen; Miaoman Ye; Puping Liang; Yingnan Zhangfang; Junjiu Huang; Mingyao Liu; Zhou Songyang; Wenbin Ma ABSTRACT Skeletal myogenesis is a multistep process in which basic helix-loop-helix (bHLH) transcription factors, such as MyoD (also known as MyoD1), bind to E-boxes and activate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3631–3645.
Published: 1 October 2015
...-206 and that through this pathway muscle cell differentiation is promoted. We next investigated whether MyoD, a major myogenic transcription factor, regulates Twist-1 because it is known that MyoD induces expression of the miR-206 gene. We found that forced MyoD expression induced miR-206 upregulation...
Includes: Supplementary data
Journal Articles
In collection:
J Cell Sci (2014) 127 (17): 3757–3767.
Published: 1 September 2014
... myogenesis involves the physical interaction of the muscle-regulatory factor MyoD with CTCF at KvDMR1, the displacement of the cohesin complex subunit Rad21 and the destabilization of the chromatin loop. The finding that MyoD affects chromatin looping at CTCF-binding sites represents the first evidence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1699–1711.
Published: 15 April 2014
.... Herein, we show that RAGE expression is low or absent in human ERMSs. We also show that in ERMS cells (1) PAX7 accumulates owing to absent or low RAGE signaling; (2) elevated PAX7 levels reduce RAGE expression and levels of MyoD and myogenin, muscle-specific transcription factors required for myoblast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (21): 3789–3795.
Published: 1 November 2010
... elongation factor b (P-TEFb) complex. It was reported recently that P-TEFb interacts with skeletal muscle-specific regulatory factor, MyoD, suggesting a linkage between CLP-1-mediated control of transcription and skeletal myogenesis. To examine this, we produced CLP-1 knockdown skeletal muscle C2C12 cells...
Journal Articles
J Cell Sci (2009) 122 (24): 4427–4438.
Published: 15 December 2009
... phenotype. Importantly, we found that PS1 also acts independently of its role in γ-secretase activity in controlling myogenesis, which is mediated in part by Id1 (inhibitor of DNA binding 1), a negative regulator of the myogenic regulatory factor MyoD. PS1 can control Id1, which affects satellite cell fate...
Journal Articles
J Cell Sci (2009) 122 (19): 3481–3491.
Published: 1 October 2009
... (HMG) family of architectural factors and binds to histone acetyltransferase p300 (p300, also known as CBP). We confirm this interaction and show that p300-dependent events (Myc expression, global histone acetylation and post-translational acetylation of the myogenic regulator MyoD) are all affected...
Journal Articles
J Cell Sci (2009) 122 (7): 1045–1053.
Published: 1 April 2009
... HepG2, revealed the importance of both MyoD expression and other unidentified cytoplasmic components, neither of which are sufficient for efficient muscle gene activation, but are synergistic. We provide evidence that de-repression by transient histone deacetylase inhibition can induce MyoD expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (4): 481–488.
Published: 15 February 2009
...Esther Schnapp; Anna Silvia Pistocchi; Evangelia Karampetsou; Efrem Foglia; Carla Lora Lamia; Franco Cotelli; Giulio Cossu Muscle regulatory factors activate myogenesis in all vertebrates, but their role has been studied in great detail only in the mouse embryo, where all but myogenin – Myod, Myf5...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (9): 1373–1382.
Published: 1 May 2008
... Pax7 without any MyoD – therefore, adopting the self-renewal pathway, with fewer cells undergoing myogenic differentiation. Similarly, preventing the degradation of endogenous β-catenin by inhibiting GSK3β activity also results in more Pax7-positive–MyoD-negative (Pax7 + MyoD – ) satellite-cell progeny...
Journal Articles
J Cell Sci (2007) 120 (22): 4050–4059.
Published: 15 November 2007
... to that of FGF2 and HGF, which both represent prototypical extracellular regulators of myogenesis. In addition, SDF1 inhibits myogenic differentiation in both C2C12 cells and primary myoblasts, as assessed by MyoD, myosin heavy chain and/or myogenin expression. Regarding signaling pathways, C2C12 cells responded...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (17): 3086–3098.
Published: 1 September 2007
...Suchitra Devi Gopinath; Shuh Narumiya; Jyotsna Dhawan Expression of the key muscle transcription factor MyoD is regulated by RhoA GTPase, which is an important regulator of adhesion-dependent signaling. We show that mDiaphanous (mDia) – an adaptor protein that mediates the effects of RhoA on cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (8): 1423–1435.
Published: 15 April 2007
...Denny L. Cottle; Meagan J. McGrath; Belinda S. Cowling; Imogen D. Coghill; Susan Brown; Christina A. Mitchell MyoD initiates muscle differentiation and promotes skeletal myogenesis by regulating temporal gene expression. MyoD-interacting proteins induce regulatory effects, and the identification...
Journal Articles
J Cell Sci (2006) 119 (9): 1824–1832.
Published: 1 May 2006
... satellite cells express the transcription factor Pax7 and when activated, coexpress Pax7 with MyoD. Most then proliferate, downregulate Pax7 and differentiate. By contrast, others maintain Pax7 but lose MyoD and return to a state resembling quiescence. Here we show that Pax7 is able to drive transcription...
Journal Articles
J Cell Sci (2005) 118 (20): 4813–4821.
Published: 15 October 2005
... decline with age. These changes are accompanied by an overall decline in fibre size, returning domain size to the normal range. Exacerbated loss of fibre nuclei per unit length during ageing of myoD -null mice provides the first experimental support for the hypothesis that a satellite cell defect causes...
Journal Articles
J Cell Sci (2004) 117 (14): 3021–3029.
Published: 15 June 2004
... for their mutual interaction. PHB2 acts as a transcriptional repressor in cells. PHB2 interacts with both MyoD and MEF2, and represses both MyoD- and MEF2-dependent gene transcription. Furthermore, binding of PHB2 to both MyoD and MEF2 significantly decreases upon myogenic differentiation. When stably expressed...
Journal Articles
J Cell Sci (2004) 117 (8): 1457–1468.
Published: 15 March 2004
...M. Komaki; A. Asakura; M. A. Rudnicki; J. Sodek; S. Cheifetz The muscle-specific, basic helix-loop-helix transcription factor MyoD can induce cells from other mesenchymal lineages to express a skeletal muscle phenotype. Interestingly, MyoD is initially upregulated in myogenic cells incubated...
Journal Articles
J Cell Sci (1992) 1992 (Supplement_16): 111–115.
Published: 1 January 1992
...MICHAEL KRAUSE; ANDREW FIRE; SUSAN WHITE-HARRISON; HAROLD WEINTRAUB; STEPHEN TAPSCOTT Summary The Caenorhabditis elegans protein, CeMyoD, is related to the vertebrate myogenic regulatory factors MyoD, myogenin, MRF-4 and Myf-5. Like its vertebrate counterparts, CeMyoD accumulates in the nucleus...