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Keywords: Myelin
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Journal Articles
J Cell Sci (2016) 129 (5): 930–942.
Published: 1 March 2016
...Isabelle Schäfer; Christina Müller; Heiko J. Luhmann; Robin White ABSTRACT Oligodendrocytes are the myelinating glial cells of the central nervous system (CNS). Myelin is formed by extensive wrapping of oligodendroglial processes around axonal segments, which ultimately allows a rapid saltatory...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2014) 127 (14): 2999–3004.
Published: 15 July 2014
...Nicolas Snaidero; Mikael Simons ABSTRACT The myelin sheath is a plasma membrane extension that is laid down in regularly spaced segments along axons of the nervous system. This process involves extensive changes in oligodendrocyte cell shape and membrane architecture. In this Cell Science...
Includes: Supplementary data
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Journal Articles
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Journal Articles
J Cell Sci (2009) 122 (7): 929–936.
Published: 1 April 2009
... activities in cultured SCs attenuated laminin-induced myelination, whereas forced activation of Rac1 and/or Cdc42 in vivo improved sorting and hypomyelinating phenotypes in SCs lacking laminins. These findings indicate that laminins play a pivotal role in regulating SC cytoskeletal signaling. Coupled...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4381–4389.
Published: 1 November 2006
...Mikael Simons; Katarina Trajkovic During the development of the central nervous system the reciprocal communication between neurons and oligodendrocytes is essential for the generation of myelin, a multilamellar insulating membrane that ensheathes the axons. Neuron-derived signalling molecules...
Journal Articles
J Cell Sci (2006) 119 (5): 807–818.
Published: 1 March 2006
...Mihaela Anitei; Marius Ifrim; Marie-Ann Ewart; Ann E. Cowan; John H. Carson; Rashmi Bansal; Steven E. Pfeiffer In the central nervous system, oligodendrocytes synthesize vast amounts of myelin, a multilamellar membrane wrapped around axons that dramatically enhances nerve transmission. A complex...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (11): 2415–2423.
Published: 1 June 2005
...Anja Schneider; Hanna Länder; Giselheid Schulz; Hartwig Wolburg; Klaus-Armin Nave; Jörg B. Schulz; Mikael Simons Myelin is a specialized membrane enriched in glycosphingolipids and cholesterol that contains a restricted set of proteins. The mechanisms by which oligodendrocytes target myelin...
Journal Articles
Journal Articles