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Keywords: Myelin
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Journal Articles
J Cell Sci (2016) 129 (5): 930–942.
Published: 01 March 2016
...Isabelle Schäfer; Christina Müller; Heiko J. Luhmann; Robin White ABSTRACT Oligodendrocytes are the myelinating glial cells of the central nervous system (CNS). Myelin is formed by extensive wrapping of oligodendroglial processes around axonal segments, which ultimately allows a rapid saltatory...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2293–2302.
Published: 01 July 2015
...Yakey Yaffe; Ilan Hugger; Inbar Nevo Yassaf; Jeanne Shepshelovitch; Ella H. Sklan; Yechiel Elkabetz; Adva Yeheskel; Metsada Pasmanik-Chor; Carola Benzing; Alexander Macmillan; Katharina Gaus; Yael Eshed-Eisenbach; Elior Peles; Koret Hirschberg ABSTRACT Myelin comprises a compactly stacked massive...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (14): 2999–3004.
Published: 15 July 2014
...Nicolas Snaidero; Mikael Simons ABSTRACT The myelin sheath is a plasma membrane extension that is laid down in regularly spaced segments along axons of the nervous system. This process involves extensive changes in oligodendrocyte cell shape and membrane architecture. In this Cell Science...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 209–220.
Published: 01 January 2013
..., most attention has focused on the myelin-associated inhibitory proteins (MAIs) Nogo-A, OMgp, and myelin-associated glycoprotein (MAG). Binding of MAIs to neuronal cell-surface receptors leads to activation of RhoA, growth cone collapse, and neurite outgrowth inhibition. In the present study, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (3): 447–458.
Published: 01 February 2011
... to different subtypes of microglia. * These authors contributed equally to this work ‡ Authors for correspondence ( schnaars@em.mpg.de ; msimons@gwdg.de ) 7 10 2010 © 2011. 2011 Macropinocytosis Microglia Myelin Oligodendrocytes Exosomes A crucial step...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (8): 1155–1162.
Published: 15 April 2009
...Alban Gaultier; Xiaohua Wu; Natacha Le Moan; Shinako Takimoto; Gatambwa Mukandala; Katerina Akassoglou; W. Marie Campana; Steven L. Gonias Multiple sclerosis (MS) is an autoimmune disease in which myelin is progressively degraded. Because degraded myelin may both initiate and accelerate disease...
Journal Articles
J Cell Sci (2009) 122 (7): 929–936.
Published: 01 April 2009
... activities in cultured SCs attenuated laminin-induced myelination, whereas forced activation of Rac1 and/or Cdc42 in vivo improved sorting and hypomyelinating phenotypes in SCs lacking laminins. These findings indicate that laminins play a pivotal role in regulating SC cytoskeletal signaling. Coupled...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4381–4389.
Published: 01 November 2006
...Mikael Simons; Katarina Trajkovic During the development of the central nervous system the reciprocal communication between neurons and oligodendrocytes is essential for the generation of myelin, a multilamellar insulating membrane that ensheathes the axons. Neuron-derived signalling molecules...
Journal Articles
J Cell Sci (2006) 119 (5): 807–818.
Published: 01 March 2006
...Mihaela Anitei; Marius Ifrim; Marie-Ann Ewart; Ann E. Cowan; John H. Carson; Rashmi Bansal; Steven E. Pfeiffer In the central nervous system, oligodendrocytes synthesize vast amounts of myelin, a multilamellar membrane wrapped around axons that dramatically enhances nerve transmission. A complex...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (11): 2415–2423.
Published: 01 June 2005
...Anja Schneider; Hanna Länder; Giselheid Schulz; Hartwig Wolburg; Klaus-Armin Nave; Jörg B. Schulz; Mikael Simons Myelin is a specialized membrane enriched in glycosphingolipids and cholesterol that contains a restricted set of proteins. The mechanisms by which oligodendrocytes target myelin...
Journal Articles
J Cell Sci (2005) 118 (6): 1267–1277.
Published: 15 March 2005
.... Immunofluorescence and immunoelectron microscopy revealed that Necl-1 localized at the contact sites among axons, their terminals, and glia cell processes that cooperatively formed synapses, axon bundles and myelinated axons. Necl-1 showed Ca 2+ -independent homophilic cell-cell adhesion activity. It furthermore...
Journal Articles
J Cell Sci (2003) 116 (6): 987–999.
Published: 15 March 2003
...Romina Chies; Lucilla Nobbio; Paolo Edomi; Angelo Schenone; Claudio Schneider; Claudio Brancolini Growth arrest specific 3 (Gas3)/peripheral myelin protein 22 (PMP22) is a component of the compact peripheral nerve myelin, and mutations affecting gas3/PMP22 gene are responsible for a group...