... in part driven by the upregulation of Myc. Furthermore, we show that the altered mitochondrial energetics, but not morphology, is required for Hipk-induced tumor-like growth, because knockdown of pdsw (also known as nd-pdsw ; NDUFB10 in mammals; a Complex I subunit) abrogates the growth. Knockdown...

...Dongqing Zheng; Jonathan H. Sussman; Matthew P. Jeon; Sydney T. Parrish; Melanie A. MacMullan; Alireza Delfarah; Nicholas A. Graham ABSTRACT Oncogenes can create metabolic vulnerabilities in cancer cells. We tested how AKT (herein referring to AKT1) and MYC affect the ability of cells to shift...

... to luminal cell differentiation. Utilizing human prostate basal epithelial cells and an in vitro differentiation model, we tested the hypothesis that regulation of NOTCH3 by the p38 MAPK family (hereafter p38-MAPK), via MYC, is required for luminal differentiation. Inhibition (SB202190 and BIRB796...

... became losers, whereas cells with increased Tead activity became super-competitors. Tead directly regulated Myc RNA expression, and cells with increased Myc expression also became super-competitors. At low cell density, cell proliferation required both Tead activity and Myc. At high cell density, however...

...Tae-Aug Kim; Jin Muk Kang; Ja-Shil Hyun; Bona Lee; Staci Jakyong Kim; Eun-Sung Yang; Suntaek Hong; Ho-Jae Lee; Makiko Fujii; John E. Niederhuber; Seong-Jin Kim ABSTRACT In most human cancers the Myc proto-oncogene is highly activated. Dysregulation of Myc oncoprotein contributes to tumorigenesis...

...Tomonobu Sato; Fumihiko Okumura; Tadashi Ariga; Shigetsugu Hatakeyama The proto-oncogene product Myc is a master regulator of cell proliferation through its specific binding to the E-box motif in genomic DNA. It has been reported that Myc has an important role in the proliferation and maintenance...

...Seung Baek Lee; Jung Jin Kim; Jin Sil Chung; Myeong-Sok Lee; Kee-Ho Lee; Byung Soo Kim; Young Do Yoo Degradation of Myc protein is mediated by E3 ubiquitin ligases, including SCF Fbw7 and SCF Skp2 , but much remains unknown about the mechanism of S-phase kinase-associated protein (Skp2)-mediated...

...Laura Kerosuo; Katja Piltti; Heli Fox; Alexandre Angers-Loustau; Valtteri Häyry; Martin Eilers; Hannu Sariola; Kirmo Wartiovaara The mechanisms underlying the decision of a stem or progenitor cell to either self-renew or differentiate are incompletely understood. To address the role of Myc...

... link in the CCND1 gene expression pathway stimulated by Myc overexpression. Our results indicate that VRK1 is a novel regulator of CCND1 expression. * Author for correspondence (e-mail: [email protected] ) 25 6 2008 © The Company of Biologists Limited 2008 2008 VRK CRE CREB...

...Anneli Gebhardt; Christian Kosan; Barbara Herkert; Tarik Möröy; Werner Lutz; Martin Eilers; Hans-Peter Elsässer Previous work has implicated the Myc-binding transcription factor Miz1 in the control of keratinocyte proliferation and in the cellular response to TGFβ. Miz1 is expressed in basal...

... into DNA. This was accompanied by increased expression of Myc, a transcription factor essential for cerebellar development, and of the cell cycle regulating gene, cyclin D1. These effects were mediated downstream by the nitric oxide-dependent second messenger, cGMP. Schedules of pharmacological...

... role(s) of p75 remains fairly unclear. To gain insight into p75 function, we have characterized its cellular binding partners and report that JPO2, a recently identified Myc-binding protein, associates with p75 in vitro and in vivo. The pseudo HEAT repeat analogous topology (PHAT) domain of p75, which...

...C. William Hooker; Peter J. Hurlin Deregulation of Myc expression is a common feature in cancer and leads to tumor formation in experimental model systems. There are several potential barriers that Myc must overcome in order to promote tumorigenesis, including its propensity to sensitize many cell...

...Robert Hopewell; Linheng Li; Douglas MacGregor; Claus Nerlov; Edward B. Ziff ABSTRACT Myc is a nuclear phosphoprotein which controls cellular proliferation, most likely by regulating gene activity. The finding that the neuronal model cell line PC12 lacks the Myc DNA binding partner, the Max protein...

... was used for quantification of these differentiation-like responses and revealed that DMSO efficiently induced expression of EGF-R, CA 125, FN and DPI+II in dosedependent manner. Immunocytochemistry, ELISA and Western blotting additionally demonstrated that both DMSO and RA caused down-regulation of myc...