... approaches, we investigated how mitochondrial dynamics and physiology adapt to radiation stress and uncover a novel role for Fis1, a pro-fission protein, in regulating the stress response through mitochondrial DNA (mtDNA) maintenance and altered mitochondrial bioenergetics. Importantly, our data demonstrate...

...Alisa Potter; Anu Hangas; Steffi Goffart; Martijn A. Huynen; Alfredo Cabrera-Orefice; Johannes N. Spelbrink ABSTRACT Molecular functions of many human proteins remain unstudied, despite the demonstrated association with diseases or pivotal molecular structures, such as mitochondrial DNA (mtDNA...

...Rasha Sabouny; Timothy E. Shutt ABSTRACT The dynamic nature of mitochondria, which can fuse, divide and move throughout the cell, allows these critical organelles to adapt their function in response to cellular demands, and is also important for regulating mitochondrial DNA (mtDNA). While...

...Iuliia E. Karavaeva; Sergey A. Golyshev; Ekaterina A. Smirnova; Svyatoslav S. Sokolov; Fedor F. Severin; Dmitry A. Knorre ABSTRACT Non-identical copies of mitochondrial DNA (mtDNA) compete with each other within a cell and the ultimate variant of mtDNA present depends on their relative replication...

... contributed equally to this work ‡ Author for correspondence ( [email protected] ) © 2010. 2010 Mitochondria Fusion Fission mtDNA Apoptosis Mitophagy Mammalian aging The aging process results in a gradual and progressive structural and functional deterioration of biomolecules...

...Alan Diot; Emmanuelle Guillou; Marlène Daloyau; Laetitia Arnauné-Pelloquin; Laurent J. Emorine; Pascale Belenguer Mitochondrial morphology depends on the equilibrium between antagonistic fission and fusion forces acting on mitochondrial membranes. Inactivation of fusion induces the loss of mtDNA...

... for correspondence (e-mail: [email protected] 14 3 2003 © The Company of Biologists Limited 2003 2003 Mitochondria Fusion Fission Fzo GTPase Organelle Human mtDNA Defects in mitochondria are thought to underlie a variety of degenerative disorders in humans. Myopathies...