... between transcription and spatial organization in embryos, we focused on ribosomal genes, which are silent initially but start to be transcribed in 2-cell mouse embryos. We demonstrated that ribosomal sequences and early unprocessed rRNAs are spatially organized in a very particular manner between 2-cell...

... that activated satellite cells are the ones that downregulate TLE4. To confirm our observations, we performed mouse muscle fiber cultures. Muscle fibers along with resident satellite cells can be isolated and cultured to study satellite cell commitment to differentiation versus self-renewal. We found...

... Macrophages CSF1 Macropinosomes Mouse Highlighted Article: Nine amino acids suppress CSF1-stimulated macropinocytosis by promoting the loss of CSF1 receptor, indicating a regulation by nutrients of growth factor receptor signaling. © 2022. Published by The Company of Biologists Ltd 2022...

...Anne Bourdais; Benoit Dehapiot; Guillaume Halet ABSTRACT How multiple actin networks coexist in a common cytoplasm while competing for a shared pool of monomers is still an ongoing question. This is exemplified by meiotic maturation in the mouse oocyte, which relies on the dynamic remodeling...

... of the phosphoinositide 5′-phosphatase gene Inpp5e , mutation of which is causative of Joubert syndrome, in terminally developed mouse olfactory sensory neurons (OSNs), leads to a dramatic remodeling of ciliary phospholipids that is accompanied by marked elongation of cilia. Phosphatidylinositol (4,5)-bisphosphate [PI...

... of motility and phosphotyrosine inhibition produced by MK571. These results were supported using spermatozoa from CatSper Ca 2+ channel knockout mice. Taken together, these results suggest that cAMP efflux via MRP4 plays an essential role in mouse sperm capacitation. This article has an associated First...

.... , Crispino , G. , Zorzi , V. , Mammano , F. and Marcotti , W. ( 2017 ). Connexin-mediated signaling in nonsensory cells is crucial for the development of sensory inner hair cells in the mouse cochlea . J. Neurosci.   37 , 258 - 268 . 10.1523/JNEUROSCI.2251-16.2016 Kalinec , G. M...

...Ryo Iwamoto; Naoki Mine; Hiroto Mizushima; Eisuke Mekada ABSTRACT Heparin-binding EGF-like growth factor (HB-EGF) plays an indispensable role in suppression of cell proliferation during mouse valvulogenesis. However, ligands of the EGF receptor (EGFR/ErbB1), including HB-EGF, are generally...

...Sarah Escuin; Bertrand Vernay; Dawn Savery; Christine B. Gurniak; Walter Witke; Nicholas D. E. Greene; Andrew J. Copp ABSTRACT The cytoskeleton is widely considered essential for neurulation, yet the mouse spinal neural tube can close despite genetic and non-genetic disruption of the cytoskeleton...

... . 10.1002/cne.22632 Fietz   S. A. , Lachmann   R. , Brandl   H. , Kircher   M. , Samusik   N. , Schröder   R. , Lakshmanaperumal   N. , Henry   I. , Vogt   J. , Riehn   A.   ( 2012 ). Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role...

.... Using immunohistochemistry, we found the glycoprotein tenascin-C in the fibrous capsule of mouse whisker follicles, along the glassy membrane and in the trabecular region surrounding keratin-15-negative, CD34-positive stem cells. The related glycoprotein tenascin-W is found in the CD34-positive stem...

... (SMC2/4) and sister-chromatid cohesion (SMC1/3). The SMC5/6 complex has been implicated in chromosome replication, DNA repair and chromosome segregation in somatic cells, but its possible functions during mammalian meiosis are unknown. Here, we show in mouse spermatocytes that SMC5 and SMC6 are located...

... at fertilization, which takes the form of a single (e.g. Xenopus ) or multiple (e.g. mouse) Ca 2+ spikes depending on the species. Store-operated Ca 2+ entry (SOCE) is the predominant Ca 2+ influx pathway in vertebrate oocytes, and in Xenopus SOCE completely inactivates during meiosis. Here, we show that SOCE...

..., and the mucosal response to acute injury in the duodenum. * Author for correspondence ( sandra.citi@unige.ch ) 30 7 2012 © 2012. Published by The Company of Biologists Ltd 2012 Cingulin Claudin-2 Mouse Tight junctions, ZO-1, Occludin, RhoA Heterozygous mice containing one...

... JNK signaling. Germline Stem cells Wnt signaling Mouse Spermatogonial stem cells (SSCs) are a rare population in testes, but are responsible for life-long sperm production. These cells are present on the basement membrane of the seminiferous tubules of the testis. Recent studies...

... to haploid gene expression, in mammalian round spermatids. However, little is known about functions and fate of the CB at later steps of spermatogenesis, when elongating spermatids undergo chromatin compaction and transcriptional silencing. In mouse elongating spermatids, we detected accumulation...

... investigated the function of the primary cilium in regulating hedgehog signaling and early cardiogenesis. We report that the pluripotent P19.CL6 mouse stem cell line, which can differentiate into beating cardiomyocytes, forms primary cilia that contain essential components of the hedgehog pathway, including...

... for correspondence (e-mail: jose.suja@uam.es ) 23 3 2009 © The Company of Biologists Limited 2009 2009 CDK2 Chromosome synapsis Meiosis Meiotic recombination Mouse Sex body The progression through the various phases of the cell cycle and subsequent cell divisions in eukaryotic cells...

... proteins 4.1G and 4.1N were previously suggested to act jointly in binding and regulating synaptic trafficking of the AMPA receptor subunits GluR1 and GluR4. To determine the functions of 4.1G and 4.1N in vivo, we generated a mutant mouse line that lacks 4.1G entirely and expresses 4.1N at 22% of wild-type...

... Center), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany 20 10 2008 © The Company of Biologists Limited 2009 2009 CD36 Macrophage fusion IL-4 Multinucleated giant cell Mouse Cell-cell fusion is a fundamental feature of the physiology and development of multicellular...