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Keywords: Motility
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Journal Articles
In collection:
Mitochondria
J Cell Sci (2021) 134 (20): jcs255299.
Published: 20 October 2021
...+ Toxoplasma Motility Membrane contact sites Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 BB/N003675/1 Wellcome Trust http://dx.doi.org/10.13039/100010269 217173/Z/19/Z Royal Society Royal Society of Edinburgh http...
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Cytoskeleton
J Cell Sci (2020) 133 (8): jcs243097.
Published: 24 April 2020
... , 2005 ; Mimori-Kiyosue et al., 2006 ; Ortiz et al., 2009 ; Pereira et al., 2006 ). Indeed, in multicellular organisms, CLASPs were observed to associate with growing microtubules at the leading edge of motile cells ( Akhmanova et al., 2001 ; Mimori-Kiyosue et al., 2005 ; Wittmann and Waterman...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (2): jcs239855.
Published: 23 January 2020
...Tom Beneke; Katherine Banecki; Sophia Fochler; Eva Gluenz ABSTRACT Motile eukaryotic flagella beat through coordinated activity of dynein motor proteins; however, the mechanisms of dynein coordination and regulation are incompletely understood. The inner dynein arm (IDA) f complex (also known...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs224071.
Published: 31 May 2019
... reduces plasma membrane fluidity and cancer cell motility . Oncogene   34 , 996 - 1005 . 10.1038/onc.2014.55 Erdogan , B. and Webb , D. J. ( 2017 ). Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis...
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Journal Articles
J Cell Sci (2019) 132 (3): jcs222851.
Published: 11 February 2019
... to deplete microtubule-stabilizing Tau in U87 cells, we determined its impact on cytoskeletal coordination during migration. We demonstrated here that the motility of these Tau-knockdown cells (shTau cells) was significantly (36%) lower than that of control cells. The shTau cells displayed a slightly changed...
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Journal Articles
J Cell Sci (2017) 130 (14): 2382–2393.
Published: 15 July 2017
...Weifeng Luo; Radoslav Janoštiak; Ondřej Tolde; Larisa M. Ryzhova; Lenka Koudelková; Michal Dibus; Jan Brábek; Steven K. Hanks; Daniel Rosel ABSTRACT The tyrosine kinase Src acts as a key regulator of cell motility by phosphorylating multiple protein substrates that control cytoskeletal and adhesion...
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Journal Articles
J Cell Sci (2017) 130 (10): 1730–1739.
Published: 15 May 2017
.../ Summary: The γ isoform of the formin FMNL1 localizes to podosomes and is required for efficient macrophage migration, independent of its FH2 actin-binding domain. Actin Formin Macrophage Motility Podosome Unwarranted macrophage activation and infiltration of tissues has been implicated...
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Journal Articles
J Cell Sci (2016) 129 (20): 3756–3769.
Published: 15 October 2016
... in polarized exocytosis, has been involved in the regulation of cell motility. Here, we show a physical and functional connection between exocyst and WRC. Purified components of exocyst and WRC directly associate in vitro , and interactions interfaces are identified. The exocyst–WRC interaction is confirmed...
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Journal Articles
J Cell Sci (2016) 129 (6): 1085–1091.
Published: 15 March 2016
... to quantitatively model actin-based motility. Funding Our laboratory is supported by a European Research Council advanced grant [grant number 249982 to M.-F.C.]; and the European Commission FP7 program ‘MitoSys’ [grant number 241548 to M.-F.C.]. References Andrianantoandro , E...
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Journal Articles
J Cell Sci (2015) 128 (4): 683–694.
Published: 15 February 2015
...Tristan W. Fowler; Archana Kamalakar; Nisreen S. Akel; Richard C. Kurten; Larry J. Suva; Dana Gaddy ABSTRACT The process of osteoclastic bone resorption is complex and regulated at multiple levels. The role of osteoclast (OCL) fusion and motility in bone resorption are unclear, with the movement...
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Journal Articles
J Cell Sci (2014) 127 (8): 1672–1683.
Published: 15 April 2014
...@wyss.harvard.edu ) Competing interests The authors declare no competing interests. 1 04 2013 22 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 Paxillin Neuropilin 2 VEGF Angiogenesis Cancer Capillary endothelial cell Motility Capillary endothelial...
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Journal Articles
J Cell Sci (2013) 126 (20): 4602–4613.
Published: 15 October 2013
...David M. Graham; Ling Huang; Kenneth R. Robinson; Mark A. Messerli Summary Ca 2+ has long been known to play an important role in cellular polarity and guidance. We studied the role of Ca 2+ signaling during random and directed cell migration to better understand whether Ca 2+ directs cell motility...
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Journal Articles
J Cell Sci (2013) 126 (11): 2381–2391.
Published: 01 June 2013
... characterised, including the extracellular-signal-regulated kinases (ERKs) 1 and 2. In a small interfering RNA (siRNA)-based high-throughput wound healing screen performed in A549 lung carcinoma cells, we identified ERK2 but not ERK1 as a strong mediator of HGF-induced motility. This finding was confirmed...
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Journal Articles
J Cell Sci (2013) 126 (8): 1733–1743.
Published: 15 April 2013
..., and primary cultures of peritoneal and bone marrow-derived macrophages. SH2B1β overexpression enhances, whereas SH2B1 knockdown inhibits, GH-dependent motility of RAW macrophages. At least two independent mechanisms regulate the SH2B1β-mediated changes in motility. In response to GH, tyrosines 439 and 494...
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Journal Articles
J Cell Sci (2013) 126 (1): 221–233.
Published: 01 January 2013
... responding to cAMP. Taken together, these findings suggest that similar components control gradient sensing during FA- and cAMP-mediated motility, but the response of polarized cells is more stable, which ultimately helps maintain their directionality. * Author for correspondence ( c.janetopoulos...
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Journal Articles
J Cell Sci (2012) 125 (21): 5015–5025.
Published: 01 November 2012
... Motility Neuronal migration SDF Migration of postmitotic neurons to their correct destinations is a cellular event essential for development of appropriate circuitry and function of the nervous system ( Rakic, 1990 ; Cameron et al., 1997 ; Hatten, 2002 ). Different modes of neuronal migration...
Journal Articles
J Cell Sci (2012) 125 (19): 4475–4486.
Published: 01 October 2012
...-invasive capacities. Thus, we identify LCN2 and TWEAKR-TWEAK as crucial downstream effectors of NFAT1 that regulate breast cancer cell motility and invasive capacity. * Author for correspondence ( sebastien.jauliac@inserm.fr ) 28 5 2012 © 2012. Published by The Company of Biologists Ltd...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (22): 3884–3892.
Published: 15 November 2010
...Benoît Maugis; Jan Brugués; Pierre Nassoy; Nancy Guillen; Pierre Sens; François Amblard We have demonstrated that the two- and three-dimensional motility of the human pathogenic parasite Entamoeba histolytica ( Eh ) depends on sustained instability of the intracellular hydrostatic pressure...
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Journal Articles
J Cell Sci (2010) 123 (20): 3425–3434.
Published: 15 October 2010
...@colorado.edu ) © 2010. 2010 Microtubule FtsZ Motility Mitosis Chromosome motion Coupler Bacterial cleavage The assembly of molecules into ordered arrays can do mechanical work. The freezing of water can crack rock, and the assembly of proteins into fibers can push on subcellular...
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Journal Articles
J Cell Sci (2010) 123 (20): 3587–3595.
Published: 15 October 2010
...Zakayi P. Kabututu; Michelle Thayer; Jason H. Melehani; Kent L. Hill Flagellar motility drives propulsion of several important pathogens and is essential for human development and physiology. Motility of the eukaryotic flagellum requires coordinate regulation of thousands of dynein motors arrayed...
Includes: Multimedia, Supplementary data