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Keywords: Motility
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Journal Articles
In collection:
Mitochondria
J Cell Sci (2021) 134 (20): jcs255299.
Published: 20 October 2021
...-dependent anion channel highlights the importance of endoplasmic reticulum–mitochondria membrane contact sites in maintaining organelle morphology. VDAC Porin Mitochondria Mitochondrion ER Ca 2+ Toxoplasma Motility Membrane contact sites Biotechnology and Biological Sciences Research...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (8): jcs243097.
Published: 24 April 2020
... deciphering the molecular mechanisms and cellular functions of CLASPs that regulate microtubule dynamics. CLASP Microtubule dynamics Mitosis Motility The name CLASP, for CLIP-associating protein, was coined in a foundational study ( Akhmanova et al., 2001 ) that identified proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (2): jcs239855.
Published: 23 January 2020
...Tom Beneke; Katherine Banecki; Sophia Fochler; Eva Gluenz ABSTRACT Motile eukaryotic flagella beat through coordinated activity of dynein motor proteins; however, the mechanisms of dynein coordination and regulation are incompletely understood. The inner dynein arm (IDA) f complex (also known...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs224071.
Published: 31 May 2019
... V600E (n=64)-expressing cells. ****P<0.0001 (Student's t-test). For all box plots, the box represents the 25–75th percentiles, and the median is indicated. The whiskers show the 5–95th percentiles, and outliers are indicated. Fig. 6. F-actin anisotropy, focal adhesion density, motility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs222851.
Published: 11 February 2019
... to deplete microtubule-stabilizing Tau in U87 cells, we determined its impact on cytoskeletal coordination during migration. We demonstrated here that the motility of these Tau-knockdown cells (shTau cells) was significantly (36%) lower than that of control cells. The shTau cells displayed a slightly changed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2382–2393.
Published: 15 July 2017
...Weifeng Luo; Radoslav Janoštiak; Ondřej Tolde; Larisa M. Ryzhova; Lenka Koudelková; Michal Dibus; Jan Brábek; Steven K. Hanks; Daniel Rosel ABSTRACT The tyrosine kinase Src acts as a key regulator of cell motility by phosphorylating multiple protein substrates that control cytoskeletal and adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1730–1739.
Published: 15 May 2017
.../ Summary: The γ isoform of the formin FMNL1 localizes to podosomes and is required for efficient macrophage migration, independent of its FH2 actin-binding domain. Actin Formin Macrophage Motility Podosome Unwarranted macrophage activation and infiltration of tissues has been implicated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3756–3769.
Published: 15 October 2016
... in polarized exocytosis, has been involved in the regulation of cell motility. Here, we show a physical and functional connection between exocyst and WRC. Purified components of exocyst and WRC directly associate in vitro , and interactions interfaces are identified. The exocyst–WRC interaction is confirmed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1085–1091.
Published: 15 March 2016
... of actin filaments at barbed ends drives motile processes. Here, we discuss the control of polarized filament assembly by various regulators that interact with and compete for barbed ends. Actin assembly Capping protein Filament barbed end Formin Motility Profilin Remodeling of the actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 683–694.
Published: 15 February 2015
...Tristan W. Fowler; Archana Kamalakar; Nisreen S. Akel; Richard C. Kurten; Larry J. Suva; Dana Gaddy ABSTRACT The process of osteoclastic bone resorption is complex and regulated at multiple levels. The role of osteoclast (OCL) fusion and motility in bone resorption are unclear, with the movement...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1672–1683.
Published: 15 April 2014
...@wyss.harvard.edu ) Competing interests The authors declare no competing interests. 1 04 2013 22 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 Paxillin Neuropilin 2 VEGF Angiogenesis Cancer Capillary endothelial cell Motility Capillary endothelial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4602–4613.
Published: 15 October 2013
...David M. Graham; Ling Huang; Kenneth R. Robinson; Mark A. Messerli Summary Ca 2+ has long been known to play an important role in cellular polarity and guidance. We studied the role of Ca 2+ signaling during random and directed cell migration to better understand whether Ca 2+ directs cell motility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2381–2391.
Published: 1 June 2013
... characterised, including the extracellular-signal-regulated kinases (ERKs) 1 and 2. In a small interfering RNA (siRNA)-based high-throughput wound healing screen performed in A549 lung carcinoma cells, we identified ERK2 but not ERK1 as a strong mediator of HGF-induced motility. This finding was confirmed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (8): 1733–1743.
Published: 15 April 2013
..., and primary cultures of peritoneal and bone marrow-derived macrophages. SH2B1β overexpression enhances, whereas SH2B1 knockdown inhibits, GH-dependent motility of RAW macrophages. At least two independent mechanisms regulate the SH2B1β-mediated changes in motility. In response to GH, tyrosines 439 and 494...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 221–233.
Published: 1 January 2013
... responding to cAMP. Taken together, these findings suggest that similar components control gradient sensing during FA- and cAMP-mediated motility, but the response of polarized cells is more stable, which ultimately helps maintain their directionality. Vegetative Cells grown on KA plates were prepared...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 5015–5025.
Published: 1 November 2012
... explants. Similar results were obtained for LDS (−21%; Table 3 ). The LDS/TDS ratios of SFM and AMD3100 recording periods were respectively 0.82 and 0.74 indicating a decrease in the motility efficiency when CXCR4 receptors are blocked in explants with MNC. Notably, administration of AMD3100 in −MNC...
Journal Articles
J Cell Sci (2012) 125 (19): 4475–4486.
Published: 1 October 2012
...-invasive capacities. Thus, we identify LCN2 and TWEAKR-TWEAK as crucial downstream effectors of NFAT1 that regulate breast cancer cell motility and invasive capacity. * Author for correspondence ( sebastien.jauliac@inserm.fr ) 28 5 2012 © 2012. Published by The Company of Biologists Ltd...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (22): 3884–3892.
Published: 15 November 2010
...Benoît Maugis; Jan Brugués; Pierre Nassoy; Nancy Guillen; Pierre Sens; François Amblard We have demonstrated that the two- and three-dimensional motility of the human pathogenic parasite Entamoeba histolytica ( Eh ) depends on sustained instability of the intracellular hydrostatic pressure...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (20): 3425–3434.
Published: 15 October 2010
... for correspondence ( richard.mcintosh@colorado.edu ) © 2010. 2010 Microtubule FtsZ Motility Mitosis Chromosome motion Coupler Bacterial cleavage The assembly of molecules into ordered arrays can do mechanical work. The freezing of water can crack rock, and the assembly of proteins into fibers...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (20): 3587–3595.
Published: 15 October 2010
...Zakayi P. Kabututu; Michelle Thayer; Jason H. Melehani; Kent L. Hill Flagellar motility drives propulsion of several important pathogens and is essential for human development and physiology. Motility of the eukaryotic flagellum requires coordinate regulation of thousands of dynein motors arrayed...
Includes: Multimedia, Supplementary data