... droplet Localization Lipolysis Lipase Inhibitor Motif Endoplasmic reticulum National Institutes of Health http://dx.doi.org/10.13039/100000002 DK089178 DK109096 Arizona State University http://dx.doi.org/10.13039/100007482 Lipid droplets (LDs) are composed...

... resulted in a decreased retention for GLUT4-W105A. We conclude that the first intracellular loop of GLUT4 contains the retention motif WLGRK, in which W105 plays a prominent role. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected]...

... to narrow the domain necessary for cilia trafficking to the first 15 amino acids of PC2 and identified a conserved motif, R 6 VxP, that is required for cilial localization. The N-terminal 15 amino acids are also sufficient to localize heterologous proteins in cilia. PC2 has endogenous cilia trafficking...

... of Phe for the Tyr 502 residue adjacent to Pro 505 or by treatment of cells with the tyrosine kinase inhibitor genistein. Ablation of the Leu 489 Leu 490 -based motif prevents the targeting of GLUT4Δ5 to GLUT4-positive-vesicles and late endosomes as well as the retention of GLUT4Δ5Phe 502 by the GSC...

... cadherin catenin cell adhesion cytoplasmic domain extracellular domain motif A group of cell membrane proteins, termed cadherins, mediate Ca 2+ -dependent and highly specific cell-cell adhesion, and are thought to play an important role during morphogenesis. So far, more than a dozen cadherins...