... in the level of CD8 expression on CD8+ cells, together with decreased expression of CD28 and CD44, and impaired production of IFN-gamma and Granzyme B. This effect was specific to hMSCs, because it was not observed with several other cell lines. Downregulation of CD8 expression required CD14+ monocytes...

...Andreas von Knethen; Nico Tzieply; Carla Jennewein; Bernhard Brüne PPARγ exerts significant anti-inflammatory signaling properties in monocytes and macrophages, which are affected by its intracellular localization. Based on our previous report, which showed that cytosolic localization of PPARγ...

... of U937 human monocytic cells as well as freshly isolated monocytes through human brain endothelial cells. Significant inhibition was observed with various anti-PrP C antibodies or blocking anti-PECAM-1 antibodies as control. Our results strongly support the conclusion that PrP C is expressed by brain...

...Federico Furlan; Simone Orlando; Carlo Laudanna; Massimo Resnati; Veronica Basso; Francesco Blasi; Anna Mondino We have previously shown that chymotrypsin-cleaved soluble uPAR (D2D3 88-274 ) elicits migration of monocytic cells through interaction with FPRL-1, a G protein-coupled receptor...

...Rita Dreier; Shona Wallace; Susanne Fuchs; Peter Bruckner; Susanne Grässel Cells of the monocyte/macrophage lineage are involved in the development of inflammatory joint diseases such as rheumatoid arthritis. This disease is characterized by cartilage degradation and synovial membrane inflammation...

...Merit Reyes-Reyes; Nancy Mora; Alejandro Zentella; Carlos Rosales ABSTRACT Integrin-mediated signals play an important but poorly understood role in regulating many leukocyte functions. In monocytes and monocytic leukemia cells, β1 integrin-mediated adhesion results in a strong induction...