...Ana Popović; Mitro Miihkinen; Sujan Ghimire; Rafael Saup; Max L. B. Grönloh; Neil J. Ball; Benjamin T. Goult; Johanna Ivaska; Guillaume Jacquemet ABSTRACT Myosin-X (MYO10), a molecular motor localizing to filopodia, is thought to transport various cargo to filopodia tips, modulating filopodia...

...Alf Månsson ABSTRACT Since the late 1990s, efforts have been made to utilize cytoskeletal filaments, propelled by molecular motors, for nanobiotechnological applications, for example, in biosensing and parallel computation. This work has led to in-depth insights into the advantages and challenges...

... into the host cell. Cytoskeletons and their molecular motors are prime targets for these effectors. In this study, we show that the microtubule molecular motor KIF1Bβ (a splice variant of KIF1B), a member of the kinesin-3 family, is a key element for the establishment of the Salmonella replication niche as its...

... attributed. Summary: The adaptor proteins HAP1a and GRIP1 form a protein complex in the brain, and co-operate to activate the kinesin-1 subunit KIF5C in vitro . Kinesin Molecular motor Microtubule transport Autoinhibition Adaptor proteins Medical Research Council 10.13039...

... it susceptible to specific proteolytic cleavage. Drosophila Kinesin Molecular motor Protease Conditional mutant Centrosomes Fluctuation analysis Deutsche Forschungsgemeinschaft 10.13039/501100001659 DFG SFB937/TP10 INST1525/16-1 FUGG Cytoskeletal motor proteins, including...

...-containing vesicles by using microtubules but, so far, no molecular motor has been assigned to the process. Here, we have identified KIF13A, a member of the kinesin-3 family, as the first molecular motor to efficiently transport vRNP-Rab11 vesicles during infection with influenza A. Depletion of KIF13A...

...Zhen-Yu She; Wan-Xi Yang ABSTRACT During eukaryote cell division, molecular motors are crucial regulators of microtubule organization, spindle assembly, chromosome segregation and intracellular transport. The kinesin-14 motors are evolutionarily conserved minus-end-directed kinesin motors...

... in Drosophila oocytes. RNA localization Molecular motor Cell polarity Actin National Institutes of Health 10.13039/100000002 R01GM100088-01 Asymmetric protein sorting underlies the establishment and maintenance of cell polarity. Recent studies have revealed that mRNA localization...

...., 2009 ; Song et al., 2009 ). However, whether cargos themselves can play an important role during selective transport, knowing exactly which motor protein to ride, how to ride, and where to go, still remains unclear. Voltage-gated potassium channel Molecular motor Axonal transport Cargo...

... 2013. Published by The Company of Biologists Ltd 2013 Microtubule Macroautophagy Phagocytosis Phagophore Cell signaling Lysosome Acetylation Molecular motor Autophagy is a catabolic process that leads to the degradation of cytoplasmic components by lysosomes. There are several...

... Fertilization Molecular motor Nuclear envelope Nucleoporin Vimentin The molecular motor cytoplasmic dynein, together with its cofactor dynactin, transports cargo organelles towards the minus ends of microtubules ( Karki and Holzbaur, 1999 ). Both are large multisubunit complexes that coordinate many...

... at the active site of the kinesins require interactions with microtubules to stabilize the movements. ‡Author for correspondence (e-mail: [email protected] ) © The Company of Biologists Limited 2002 2002 Molecular motor Structure/function Conformational changes Kinesin Myosin Life...

....uchc.edu ) 14 06 2000 © 2000 by Company of Biologists 2000 AAA domain Dynein Flagellum Microtubule Molecular motor Dyneins, kinesins and myosins represent the three major classes of molecular motor that translocate along cytoskeletal elements. The kinesins and myosins have...

...Sharyn A. Endow ABSTRACT Molecular motors perform essential functions in the cell and have the potential to provide insights into the basis of many important processes. A unique property of molecular motors is their ability to convert energy from ATP hydrolysis into work, enabling the motors...

... Molecular motor Melanocyte Green fluorescent protein Nocodazole Cytochalasin D An important issue in understanding possible functions of myosin-V is the elucidation of the molecular domains involved in targeting this motor molecule to specific intracellular sites. For many unconventional myosins...

... and Microbiology, LMU, Maria-Ward-Str. 1a, 80638 Munich, Germany (e-mail: [email protected] ) 24 05 1998 15 07 1998 © 1998 by Company of Biologists 1998 Kinesin Null mutant Endocytosis Organelle transport Fungus Smut Dimorphism Tip growth Molecular motor...

... ). Expression of recombinant inhibitor-2 in E. coli and its utilization for the affinity chromatography of protein phosphatase-1 . Arch. Biochem. Biophys . 308 , 37 – 41 . 06 02 1996 28 03 1996 © 1996 by Company of Biologists 1996 cAMP-dependent kinase Molecular motor...

... optical trap brush border spectrin skeletal tropomyosin molecular motor Mechanochemical analysis of myosins has been performed primarily using the exposed actin cables of dissected alga cells ( Sheetz and Spudich, 1983 ; Shimmen and Yano, 1984 ), the sliding actin filament assay ( Kron...

... of Biologists 1994 cell motility cilium microtubule cytoplasmic transport molecular motor Although much is known about dynein ATPases and their roles in cilia and flagella ( Witman, 1992 ), the presence of other microtubule-associated molecular motors has not been determined. In this work...