...Kévin Leguay; Barbara Decelle; Yu Yan He; Anthony Pagniez; Mireille Hogue; Hiroyuki Kobayashi; Christian Le Gouill; Michel Bouvier; Sébastien Carréno ABSTRACT Ezrin, radixin and moesin compose the family of ERM proteins. They link actin filaments and microtubules to the plasma membrane to control...

...-1-1/ Summary: The dynamics of the evolutionarily conserved polarity regulator Crumbs at the plasma membrane is important for modulating junctional stability and tension during embryonic development of Drosophila . Apical Moesin β H -spectrin FERM protein FRAP Morphogenesis...

... form of the ERM protein moesin precludes the Ano1-dependent increase in membrane area. Furthermore, both full-length and the truncated dominant-negative forms of moesin co-localize with Ano1 to the microvilli, and the two proteins co-immunoprecipitate. The Ano1–moesin interaction limits Ano1 lateral...

...Andrea I. McClatchey ABSTRACT The cell cortex is a dynamic and heterogeneous structure that governs cell identity and behavior. The ERM proteins (ezrin, radixin and moesin) are major architects of the cell cortex, and they link plasma membrane phospholipids and proteins to the underlying cortical...

... of plasma membrane PtdIns4 P and PtdIns(4,5) P 2 and is crucial for actin organization, membrane trafficking and cell polarity. Female germ cells mutant for PI4KIIIα exhibit defects in cortical integrity associated with failure to recruit the cytoskeletal-membrane crosslinker Moesin and the exocyst subunit...

.... In addition, SrcY527F was less able to induce podosome rosettes in JNK1-null or JNK2-null mouse embryo fibroblasts than in wild-type counterparts. The kinase activity of JNK was essential for promoting podosome rosette formation but not for its localization to podosome rosettes. Moesin, a member of the ERM...

... inhibition of PLC. Severe retinal degeneration was also induced in the dark in otherwise wild-type flies by overexpression of a bacterial PtdIns P n phosphatase (SigD) to deplete PtdIns(4,5) P 2 . In degenerating trp photoreceptors, phosphorylated Moesin, a PtdIns(4,5) P 2 -regulated membrane–cytoskeleton...

...Fernando Roch; Cédric Polesello; Chantal Roubinet; Marianne Martin; Christian Roy; Philippe Valenti; Sébastien Carreno; Paul Mangeat; François Payre The ezrin, radixin and moesin (ERM) proteins regulate cell membrane architecture in several cellular contexts. Current models propose that ERM...

... transition from fluid to adhesive conditions involves an early polarization event and major rearrangements of the submembrane cytoskeleton that remain poorly understood. As regulation of cortical actin-membrane binding might be important in this process, we investigated the role of ezrin and moesin, which...

..., while actin-binding proteins such as ezrin and moesin direct binding of signaling molecules to actin filaments within the distal pole complex. References Allenspach, E. J., Cullinan, P., Tong, J., Tang, Q., Tesciuba, A. G., Cannon, J. L., Takahashi, S. M., Morgan, R., Burkhardt, J. K. and Sperling...

...Casey M. Finnerty; David Chambers; Janet Ingraffea; H. Richard Faber; P. Andrew Karplus; Anthony Bretscher Members of the ezrin-radixin-moesin (ERM) protein family serve as regulated microfilament-membrane crosslinking proteins that, upon activation, bind the scaffolding protein ERM-phosphoprotein...

...), usually together with moesin, spectrin(s) and plectin. In sections through lens fiber tissue, the short sides of the lens fiber hexagons appear to be enriched in the cadherin-based complexes, whereas the EPPD complexes also occur on the long sides. Moreover, high resolution double-label fluorescence...

..., and the actin-binding domain of moesin fused to cyan fluorescent protein (cfp-Moe) to stain actin. Actin filament bundles were clearly seen in the protruding lamellae of the cells. FN matrix assembly appeared to be initiated as small spots of FN at the ends of actin filament bundles. The spots then elongated...

...Ken Hayashi; Shigenobu Yonemura; Takeshi Matsui; Sachiko Tsukita; Shoichiro Tsukita ABSTRACT Ezrin/radixin/moesin (ERM) proteins are thought to play an important role in organizing cortical actin-based cytoskeletons through cross-linkage of actin filaments with integral membrane proteins. Recent...

...Manuel R. Amieva; Pninit Litman; Laiqiang Huang, Eiji Ichimaru; Heinz Furthmayr ABSTRACT Lamellipodia, filopodia, microspikes and retraction fibers are characteristic features of a dynamic and continuously changing cell surface architecture and moesin, ezrin and radixin are thought to function...

...Eric Scott Bachman; David R. McClay ABSTRACT We have investigated the distribution and function of an ezrin-radixin-moesin-like (ERM) molecule in the sea urchin. A sea urchin homologue of moesin was cloned that shares 75% amino acid similarity in the conserved N-terminal region to other moesin...

..., 77 and 72 kDa by overlay assay. The 80 kDa protein was identified as ezrin and the 77 and 72 kDa proteins as gastric forms of proteins structurally related to ezrin, such as radixin and moesin. In insect cells infected with a recombinant baculovirus, one-third of over-expressed ezrin accumulated...

...Mark Berryman; Zsofia Franck; Anthony Bretscher ABSTRACT Ezrin and moesin are two cytoskeletal proteins originally purified from human placenta that are 74% identical in overall protein sequence. They are believed to be membrane-cytoskeletal linking proteins because they share sequence homology...

...Zsofia Franck; Ronald Gary; Anthony Bretscher ABSTRACT The band 4.1 superfamily of proteins show approx. 30% sequence identity in their amino-terminal region to the membrane binding domain of erythrocyte band 4.1. Within this superfamily are three members, ezrin, radixin and moesin, that show...

... encoding mouse radixin was isolated, showing that radixin is highly homologous to but distinct from ezrin. From mouse teratocarcinoma cells we isolated and analyzed cDNA encoding another radixin-related protein. Sequence analysis has demonstrated that this protein is a mouse homologue of human moesin (98.3...