1-20 of 36
Keywords: Mitotic spindle
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2021) 134 (3): jcs255794.
Published: 01 February 2021
...Ellis L. Ryan; James Shelford; Teresa Massam-Wu; Richard Bayliss; Stephen J. Royle ABSTRACT A multiprotein complex containing TACC3, clathrin and other proteins has been implicated in mitotic spindle stability. To disrupt this complex in an anti-cancer context, we need to understand its composition...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs247155.
Published: 23 July 2020
... of STAU1 localizes to the mitotic spindle in colorectal cancer HCT116 cells and in non-transformed hTERT-RPE1 cells. Spindle-associated STAU1 partly co-localizes with ribosomes and active sites of translation. We mapped the molecular determinant required for STAU1–spindle association within the first 88 N...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs211664.
Published: 13 April 2018
... is the short isoform of Samp1) distributed as filamentous structures in the mitotic spindle, partially colocalising with β-tubulin. Samp1 depletion resulted in an increased frequency of cells with signs of chromosomal mis-segregation and prolonged metaphase, indicating problems with spindle assembly...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2017) 130 (10): 1845–1855.
Published: 15 May 2017
... at the resolution limit of the method, we describe a correlative light–SBF-SEM workflow to resolve microtubules of the mitotic spindle in human cells. We present four examples of uses for this workflow that are not practical by light microscopy and/or transmission electron microscopy. First, distinguishing closely...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2017) 130 (4): 725–734.
Published: 15 February 2017
.... ( 1992 ). Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly . J. Cell Biol.   118 , 109 - 120 . 10.1083/jcb.118.1.109 Jaqaman , K. , Loerke , D. , Mettlen , M. , Kuwata , H. , Grinstein , S. , Schmid , S. L. and Danuser...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1481–1493.
Published: 15 April 2015
...Imène B. Bouhlel; Midori Ohta; Adeline Mayeux; Nicole Bordes; Florent Dingli; Jérôme Boulanger; Guilhem Velve Casquillas; Damarys Loew; Phong T. Tran; Masamitsu Sato; Anne Paoletti Spindle pole biogenesis and segregation are tightly coordinated to produce a bipolar mitotic spindle. In yeasts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (19): 4369–4380.
Published: 01 October 2013
... and dynamics of MTs is essential for the precise formation of the mitotic spindle. Spindle MTs are highly acetylated, but the mechanism regulating this acetylation is largely unknown. Furry (Fry) is an evolutionarily conserved protein that binds to MTs and colocalizes with acetylated MTs in the mitotic spindle...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3417–3428.
Published: 01 August 2013
...Zhige Wu; Qing Jiang; Paul R. Clarke; Chuanmao Zhang Summary Mitotic spindle assembly in animal cells is orchestrated by a chromosome-dependent pathway that directs microtubule stabilization. RanGTP generated at chromosomes releases spindle assembly factors from inhibitory complexes with importins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 2102–2113.
Published: 01 May 2013
...Liam P. Cheeseman; Edward F. Harry; Andrew D. McAinsh; Ian A. Prior; Stephen J. Royle Summary Microtubule-associated proteins of the mitotic spindle are thought to be important for the initial assembly and the maintenance of spindle structure and function. However, distinguishing assembly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5830–5839.
Published: 01 December 2012
.... The increased probability that all three cMTs orient in one direction explains the high rate of nuclear bypassing observed in these nuclei. The A. gossypii mitotic spindle was found to be structurally similar to that of Saccharomyces cerevisiae in terms of nuclear microtubule (nMT) number, length distribution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (22): 5403–5416.
Published: 15 November 2012
... to the centrosome, we examined its mitotic fate and possible role in Golgi breakdown. The use of multiple imaging techniques and markers revealed that the IC elements persist during the M phase, maintain their compositional and structural properties and remain associated with the mitotic spindle, forming circular...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (19): 4423–4433.
Published: 01 October 2012
... important roles in cell cycle control. In particular, NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response. Roles for NEKs in other aspects of mitotic progression, such as chromatin...
Journal Articles
J Cell Sci (2012) 125 (4): 906–918.
Published: 15 February 2012
... contributed equally to this work ‡ Author for correspondence ( patrick.meraldi@bc.biol.ethz.ch ) 28 8 2011 © 2012. 2012 CCAN Centrosome Kinetochore Microtubule poleward flux Mitosis Mitotic Spindle Chromosome segregation in somatic animal cells requires the separation...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 19–28.
Published: 01 January 2012
... of the mitotic spindle and proposed that clathrin crosslinks the microtubules (MTs) comprising the kinetochore fibres (K-fibres) in the mitotic spindle. This mitotic function is unrelated to the role of clathrin in membrane trafficking and occurs in partnership with two other spindle proteins: transforming...
Journal Articles
J Cell Sci (2011) 124 (14): 2341–2348.
Published: 15 July 2011
... examine the effect of phosphorylation on CK2α localization. Using phosphospecific antibodies, we show that CK2α localizes to the mitotic spindle in a phosphorylation-dependent manner. Mitotic spindle localization requires the unique C-terminus of CK2α, and involves a novel regulatory mechanism in which...
Journal Articles
J Cell Sci (2011) 124 (7): 1156–1166.
Published: 01 April 2011
... to the centrosome. In these cells, mutation in jub leads to centrosome separation defects and aberrant mitotic spindles, which is a phenotype similar to that of aur-A mutants. We show that in jub mutants Aur-A activity is not perturbed, but that Aur-A recruitment and maintenance at the centrosome is affected...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (20): 3435–3445.
Published: 15 October 2010
...Alex Mogilner; Erin Craig The ‘simple’ view of the mitotic spindle is that it self-assembles as a result of microtubules (MTs) randomly searching for chromosomes, after which the spindle length is maintained by a balance of outward tension exerted by molecular motors on the MTs connecting...
Journal Articles
J Cell Sci (2010) 123 (5): 736–746.
Published: 01 March 2010
... Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany ¶ Present address: Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, 1030 Vienna, Austria 17 12 2009 © 2010. 2010 Adenomatous polyposis coli Importin-β Microtubules Mitotic spindle Adenomatous...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2750–2759.
Published: 01 August 2009
... for correspondence (e-mail: fang.guowei@gene.com ) 5 5 2009 © The Company of Biologists Limited 2009 2009 Plk1 FAM29A NEDD1 Centrosome Mitotic spindle Microtubule amplification Nucleation of microtubules (MTs) initiates the assembly of the mitotic spindle. MT nucleation is also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 2100–2107.
Published: 15 June 2009
.... At the onset of mitosis, most of the protein dispersed out into the ER, as expected. However, during mitosis, a significant fraction of the protein specifically localized to the polar regions of the mitotic spindle. We demonstrate for the first time, in human cells, the existence of a membranous structure...