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Keywords: Mitotic exit
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Journal Articles
J Cell Sci (2017) 130 (16): 2673–2681.
Published: 15 August 2017
...Brendan L. Powers; Mark C. Hall ABSTRACT Inactivation of cyclin-dependent kinase (Cdk) and reversal of Cdk phosphorylation are universally required for mitotic exit. In budding yeast ( Saccharomyces cerevisiae ), Cdc14 is essential for both and thought to be the major Cdk-counteracting phosphatase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1329–1339.
Published: 01 April 2016
... phosphorylation of mitotic proteins. Upon mitotic exit, cyclin-B–Cdk1 and Gwl kinases are inactivated, and mitotic substrates are dephosphorylated. Here, we have identified protein phosphatase-1 (PP1) as the phosphatase involved in the dephosphorylation of the activating site (Ser875) of Gwl. Depletion of PP1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1340–1354.
Published: 01 April 2016
... with, and capable of partially dephosphorylating and deactivating, MASTL during mitotic exit. Using mathematical modelling, we were able to confirm that deactivation of MASTL is essential for mitotic exit. Furthermore, small decreases in Cdk1 activity during metaphase are sufficient to initiate the reactivation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3466–3477.
Published: 15 September 2015
...Allana Schooley; Daniel Moreno-Andrés; Paola De Magistris; Benjamin Vollmer; Wolfram Antonin ABSTRACT The metazoan nucleus breaks down and reassembles during each cell division. Upon mitotic exit, the successful reestablishment of an interphase nucleus requires the coordinated reorganization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (13): 2845–2856.
Published: 01 July 2013
... kinases, AurB is a target of the anaphase-promoting complex (APC/C) ubiquitin ligase during mitotic exit, but it is not known if APC/C-mediated destruction plays any specific role in controlling AurB activity. We have examined the contribution of the Cdh1 coactivator-associated APC/C Cdh1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2875–2884.
Published: 15 June 2012
... mitotic regulator that counteracts cyclin-dependent kinase (Cdk) activity during mitotic exit. Separase, together with Zds1p, promotes the downregulation of the protein phosphatase 2A in conjunction with its Cdc55p regulatory subunit (PP2A Cdc55 ) in early anaphase, enabling accumulation of phosphorylated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (17): 2867–2876.
Published: 01 September 2010
... of organisms from yeast to human. Human CDC14B is even able to fulfill the essential functions of budding yeast Cdc14. In budding yeast, Cdc14 counteracts the activity of cyclin dependent kinase (Cdk1) at the end of mitosis and thus has important roles in the regulation of anaphase, mitotic exit...
Journal Articles
J Cell Sci (2007) 120 (8): 1325–1329.
Published: 15 April 2007
... system of Xenopus egg extracts. The role of p97 in spindle disassembly during meiotic exit should therefore be reconsidered. * Author for correspondence (e-mail: stemmann@biochem.mpg.de ) 14 2 2007 © The Company of Biologists Limited 2007 2007 Microtubules Mitotic exit p97...
Journal Articles
J Cell Sci (2006) 119 (6): 1130–1143.
Published: 15 March 2006
... , and demonstrated that its deletion results in defects in cell separation, mitotic exit and morphogenesis. The C. albicans cdc14 Δ mutants formed large aggregates of cells that resembled those found in ace2 -null strains. In cdc14 Δ cells, expression of Ace2p target genes was reduced and Ace2p did not accumulate...
Journal Articles
J Cell Sci (2004) 117 (12): 2461–2468.
Published: 15 May 2004
... of cytokinesis with other cell cycle events. 16 1 2004 © The Company of Biologists Limited 2004 2004 flp1 + Cell cycle Mitotic exit Fission yeast Exit from mitosis in eukaryotic cells requires the inactivation of mitotic cyclin-dependent kinases (CDKs) ( Morgan, 1999 ; Bardin...
Journal Articles
J Cell Sci (2004) 117 (2): 199–209.
Published: 15 January 2004
... the complementing gene, nimU , which encodes a protein related to Pot1 and other telomere end-binding proteins. We show that loss of nimU function leads to premature mitotic spindle elongation, premature mitotic exit, errors in chromosome segregation, and failure to delay mitotic exit under conditions that normally...
Journal Articles
J Cell Sci (2003) 116 (21): 4263–4275.
Published: 01 November 2003
...Viesturs Simanis The mitotic exit network (MEN) and the septation initiation network (SIN) control events at the end of mitosis in S. cerevisiae and S. pombe , respectively. SIN initiates contraction of the actin ring and synthesis of the division septum, thereby bringing about cytokinesis. The MEN...
Journal Articles
J Cell Sci (2002) 115 (24): 4977–4991.
Published: 15 December 2002
... for correspondence (e-mail: ljohnst@nimr.mrc.ac.uk ) 22 9 2002 © The Company of Biologists Limited 2002 2002 Cell cycle Mitotic exit Polarity Cdc14 Budding yeast Accurate chromosome partitioning is of fundamental importance to the continued genome integrity and survival of a species...
Journal Articles
J Cell Sci (2001) 114 (14): 2649–2664.
Published: 15 July 2001
... of the cyclin-dependent kinase inhibitor Sic1p. Cdc14p is sequestered in the nucleolus during interphase, from where it is released at the end of mitosis, dependent upon mitotic exit network function. The CDC14 gene is essential and loss-of-function mutants arrest at the end of mitosis. We have identified...