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Keywords: Mitotic Spindle
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2024) 137 (5): jcs261701.
Published: 28 November 2023
... and crosstalk of microtubules and actin at the cell cortex, thereby regulating the mitotic spindle machinery and chromosome segregation. Yet, the precise mechanisms linking plasma membrane remodelling to cell polarity and cortical cytoskeleton dynamics to ensure accurate execution of mitosis in mammalian...
Includes: Supplementary data
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Cell cycle
J Cell Sci (2023) 136 (2): jcs260547.
Published: 20 January 2023
...Anchi S. Chann; Ye Chen; Tanja Kinwel; Patrick O. Humbert; Sarah M. Russell ABSTRACT The fate of the two daughter cells is intimately connected to their positioning, which is in turn regulated by cell junction remodelling and orientation of the mitotic spindle. How multiple cues are integrated...
Includes: Supplementary data
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Cytoskeleton
J Cell Sci (2022) 135 (3): jcs258745.
Published: 2 February 2022
...Aaron R. Tipton; Gary J. Gorbsky ABSTRACT The microtubules of the mitotic spindle mediate chromosome alignment to the metaphase plate, then sister chromatid segregation to the spindle poles in anaphase. Previous analyses of spindle microtubule kinetics utilizing fluorescence dissipation after...
Includes: Supplementary data
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Journal Articles
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In collection:
Cytoskeleton
J Cell Sci (2017) 130 (4): 725–734.
Published: 15 February 2017
... in fission yeast . Nature   356 , 74 - 76 . 10.1038/356074a0 Hoyt , M. A. , He , L. , Loo , K. K. and Saunders , W. S. ( 1992 ). Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly . J. Cell Biol.   118 , 109 - 120 . 10.1083/jcb...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1481–1493.
Published: 15 April 2015
...Imène B. Bouhlel; Midori Ohta; Adeline Mayeux; Nicole Bordes; Florent Dingli; Jérôme Boulanger; Guilhem Velve Casquillas; Damarys Loew; Phong T. Tran; Masamitsu Sato; Anne Paoletti Spindle pole biogenesis and segregation are tightly coordinated to produce a bipolar mitotic spindle. In yeasts...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (15): 3417–3428.
Published: 1 August 2013
...Zhige Wu; Qing Jiang; Paul R. Clarke; Chuanmao Zhang Summary Mitotic spindle assembly in animal cells is orchestrated by a chromosome-dependent pathway that directs microtubule stabilization. RanGTP generated at chromosomes releases spindle assembly factors from inhibitory complexes with importins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 2102–2113.
Published: 1 May 2013
...Liam P. Cheeseman; Edward F. Harry; Andrew D. McAinsh; Ian A. Prior; Stephen J. Royle Summary Microtubule-associated proteins of the mitotic spindle are thought to be important for the initial assembly and the maintenance of spindle structure and function. However, distinguishing assembly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5830–5839.
Published: 1 December 2012
.... The increased probability that all three cMTs orient in one direction explains the high rate of nuclear bypassing observed in these nuclei. The A. gossypii mitotic spindle was found to be structurally similar to that of Saccharomyces cerevisiae in terms of nuclear microtubule (nMT) number, length distribution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (22): 5403–5416.
Published: 15 November 2012
... to the centrosome, we examined its mitotic fate and possible role in Golgi breakdown. The use of multiple imaging techniques and markers revealed that the IC elements persist during the M phase, maintain their compositional and structural properties and remain associated with the mitotic spindle, forming circular...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (19): 4423–4433.
Published: 1 October 2012
... important roles in cell cycle control. In particular, NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response. Roles for NEKs in other aspects of mitotic progression, such as chromatin...
Journal Articles
J Cell Sci (2012) 125 (4): 906–918.
Published: 15 February 2012
... contributed equally to this work ‡ Author for correspondence ( [email protected] ) 28 8 2011 © 2012. 2012 CCAN Centrosome Kinetochore Microtubule poleward flux Mitosis Mitotic Spindle Chromosome segregation in somatic animal cells requires the separation...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 19–28.
Published: 1 January 2012
... of the mitotic spindle and proposed that clathrin crosslinks the microtubules (MTs) comprising the kinetochore fibres (K-fibres) in the mitotic spindle. This mitotic function is unrelated to the role of clathrin in membrane trafficking and occurs in partnership with two other spindle proteins: transforming...
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (7): 1156–1166.
Published: 1 April 2011
... to the centrosome. In these cells, mutation in jub leads to centrosome separation defects and aberrant mitotic spindles, which is a phenotype similar to that of aur-A mutants. We show that in jub mutants Aur-A activity is not perturbed, but that Aur-A recruitment and maintenance at the centrosome is affected...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (20): 3435–3445.
Published: 15 October 2010
...Alex Mogilner; Erin Craig The ‘simple’ view of the mitotic spindle is that it self-assembles as a result of microtubules (MTs) randomly searching for chromosomes, after which the spindle length is maintained by a balance of outward tension exerted by molecular motors on the MTs connecting...