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Keywords: Mitophagy
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Journal Articles
Journal Articles
J Cell Sci (2023) 136 (11): jcs260638.
Published: 6 June 2023
... preserving neuronal energy homeostasis. Here, we review the contribution of mitophagy, a selective form of autophagy that targets dysfunctional or superfluous mitochondria for degradation, in maintaining nervous system homeostasis. In addition, we discuss recent evidence implicating defective or dysregulated...
Journal Articles
J Cell Sci (2022) 135 (23): jcs259748.
Published: 12 December 2022
... biogenesis and degradation. Defective targeting of dysfunctional mitochondria to lysosomes through mitophagy has been linked to several diseases, but the underlying mechanisms and the relative importance of distinct mitophagy pathways in vivo are largely unknown. In this Cell Science at a Glance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (23): jcs260395.
Published: 7 December 2022
...Keitaro Fujita; Shin Kedashiro; Takuya Yagi; Naoki Hisamoto; Kunihiro Matsumoto; Hiroshi Hanafusa ABSTRACT Mitophagy, a type of selective autophagy, specifically targets damaged mitochondria. The ULK complex regulates Parkin-mediated mitophagy, but the mechanism through which the ULK complex...
Includes: Supplementary data
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Mitochondria
J Cell Sci (2022) 135 (6): jcs259455.
Published: 21 March 2022
... Mitochondria Lysosome Cancer Ca 2+ Mitophagy Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 VO 376/19-1 BI 484/6-1 GR 4315/2-1 BR 1034/7-1 Ludwig-Maximilians-Universität München http://dx.doi.org/10.13039/501100005722 Liver cancers...
Includes: Supplementary data
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In collection:
Mitochondria
J Cell Sci (2021) 134 (24): jcs258944.
Published: 15 December 2021
... interests. © 2021. Published by The Company of Biologists Ltd 2021 Summary: A review of how the dynamic nature of the mitochondrial network is important for maintenance of the mitochondrial genome. Fission Fusion Mitochondria Mitochondrial dynamics Mitophagy mtDNA Natural...
Journal Articles
Journal Articles
J Cell Sci (2020) 133 (21): jcs247379.
Published: 12 November 2020
..., the function of which remains to be elucidated. Here, we report that mitochondrial survivin inhibits the selective form of autophagy called ‘mitophagy’, causing an accumulation of respiratory-defective mitochondria. Mechanistically, the data reveal that survivin prevents recruitment of the E3-ubiquitin ligase...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2018) 131 (18): jcs215152.
Published: 20 September 2018
...., 2017a ). Similarly, ERK1/2-dependent mitophagy and cell death of SH-SY5Y neuroblastoma cells in response to MPP(+) or 6-OHDA also occurs independently of Beclin-1 or Vps34 activity, which contrasted with starvation-induced autophagy in these same cells ( Dagda et al., 2008 ; Zhu et al., 2007 ). In both...
Journal Articles
J Cell Sci (2017) 130 (16): 2657–2662.
Published: 15 August 2017
... , A. H. , Boland , M. L. and Macleod , K. F. ( 2015 ). Mitophagy and cancer . Cancer Metab.   3 , 4 . 10.1186/s40170-015-0130-8 Clauson , C. , Scharer , O. D. and Niedernhofer , L. ( 2013 ). Advances in understanding the complex mechanisms of DNA interstrand cross...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (7): 1274–1284.
Published: 1 April 2017
... molecules. mtDNA Uncoupler Heteroplasmy Mitophagy Mitochondrial dynamics ATG32 Summary: Uncouplers activate mitochondrial degradation in heteroplasmic yeast zygotes and prevent clonal expansion of selfish mitochondrial DNA. This effect requires mitochondrial fission and autophagy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 757–773.
Published: 15 February 2016
... constitutively low levels of GP78 in healthy cells, in turn downregulating mitophagy. GP78, however, does not regulate MGRN1. When mitochondria are stressed, cytosolic Ca 2+ increases. This leads to a reduced interaction between MGRN1 and GP78 and its compromised ubiquitylation. Chelating Ca 2+ restores...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (16): 3488–3504.
Published: 15 August 2014
... of mitochondrial proteins and whole organelles via the proteasome and the autophagy-lysosome pathway (mitophagy). The mitochondrial kinase PINK1 activates and recruits the E3 ubiquitin ligase Parkin to de-energized mitochondria. However, the cognate E2 co-enzymes of Parkin in this ubiquitin-dependent pathway have...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2011) 124 (8): 1339–1350.
Published: 15 April 2011
... mitochondria have been proposed to be targeted for selective degradation by mitophagy, thereby providing a quality control system for mitochondria. In yeast, conflicting results concerning the role of mitochondrial dynamics in mitophagy have been reported. Here, we investigate the effects on mitophagy...
Includes: Supplementary data