... elegans nuclear hormone receptor NHR-85 as a putative orthologue of human PPARδ. Furthermore, we show that NHR-85 functions as an essential regulator of fat and energy metabolism, with significant impact on mitochondrial homeostasis, at least in part through modulation of mitophagy. Finally, we find...

.... Mitochondrial dysfunction plays a key role in the pathogenesis of myocardial ischemia and reperfusion injury. Dysfunctional mitochondria can be removed by mitophagy, culminating in their degradation within acidic lysosomes. Mitophagy is pivotal in maintaining cardiac homeostasis and emerges as a potential...

... fission. Here, we found that MTP18 functions as a mitophagy receptor that targets dysfunctional mitochondria into autophagosomes for elimination. Interestingly, MTP18 interacts with members of the LC3 (also known as MAP1LC3) family through its LC3-interacting region (LIR) to induce mitochondrial autophagy...

... preserving neuronal energy homeostasis. Here, we review the contribution of mitophagy, a selective form of autophagy that targets dysfunctional or superfluous mitochondria for degradation, in maintaining nervous system homeostasis. In addition, we discuss recent evidence implicating defective or dysregulated...

... biogenesis and degradation. Defective targeting of dysfunctional mitochondria to lysosomes through mitophagy has been linked to several diseases, but the underlying mechanisms and the relative importance of distinct mitophagy pathways in vivo are largely unknown. In this Cell Science at a Glance...

...Keitaro Fujita; Shin Kedashiro; Takuya Yagi; Naoki Hisamoto; Kunihiro Matsumoto; Hiroshi Hanafusa ABSTRACT Mitophagy, a type of selective autophagy, specifically targets damaged mitochondria. The ULK complex regulates Parkin-mediated mitophagy, but the mechanism through which the ULK complex...

... Mitochondria Lysosome Cancer Ca 2+ Mitophagy Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 VO 376/19-1 BI 484/6-1 GR 4315/2-1 BR 1034/7-1 Ludwig-Maximilians-Universität München http://dx.doi.org/10.13039/501100005722 Liver cancers...

... of the mitochondrial network are important for mediating the distribution of nucleoids throughout the mitochondrial network, maintaining mtDNA copy number, and regulating mtDNA heteroplasmy. In addition, mitophagy, which is linked to mitochondrial fission and fusion, is also important for mtDNA turnover, which could...

...Jasvinder Kaur; Juliet Goldsmith; Alexandra Tankka; Sofía Bustamante Eguiguren; Alfredo A. Gimenez; Lance Vick; Jayanta Debnath; Ariadne Vlahakis ABSTRACT In Saccharomyces cerevisiae , the selective autophagic degradation of mitochondria, termed mitophagy, is critically regulated by the adapter...

..., the function of which remains to be elucidated. Here, we report that mitochondrial survivin inhibits the selective form of autophagy called ‘mitophagy’, causing an accumulation of respiratory-defective mitochondria. Mechanistically, the data reveal that survivin prevents recruitment of the E3-ubiquitin ligase...

...Pierre Vigié; Elodie Cougouilles; Ingrid Bhatia-Kiššová; Bénédicte Salin; Corinne Blancard; Nadine Camougrand ABSTRACT Mitophagy, the selective degradation of mitochondria by autophagy, is a central process that is essential for the maintenance of cell homeostasis. It is implicated in the clearance...

... kill a cell. Summary: A review of recent findings that demonstrate autophagy-dependent cell death in various contexts and begin to elucidate molecular mechanisms that render autophagy a lethal process. ADCD Autophagy Cell death Ceramide Mitophagy European Research Council...

... pathophysiology are examined. Selective autophagy Fanconi anemia Mitophagy Inflammasome Virophagy DNA damage response National Institutes of Health 10.13039/100000002 K08 AI099150 U19 AI109725 RO1 CA109618 Burroughs Wellcome Fund 10.13039/100000861 University...

... zygotes and prevent clonal expansion of selfish mitochondrial DNA. This effect requires mitochondrial fission and autophagy. mtDNA Uncoupler Heteroplasmy Mitophagy Mitochondrial dynamics ATG32 Russian Science Foundation 10.13039/501100006769 14-50-00029 Russian Foundation...

... constitutively low levels of GP78 in healthy cells, in turn downregulating mitophagy. GP78, however, does not regulate MGRN1. When mitochondria are stressed, cytosolic Ca 2+ increases. This leads to a reduced interaction between MGRN1 and GP78 and its compromised ubiquitylation. Chelating Ca 2+ restores...

... of mitochondrial proteins and whole organelles via the proteasome and the autophagy-lysosome pathway (mitophagy). The mitochondrial kinase PINK1 activates and recruits the E3 ubiquitin ligase Parkin to de-energized mitochondria. However, the cognate E2 co-enzymes of Parkin in this ubiquitin-dependent pathway have...

...Sven Geisler; Stefanie Vollmer; Sonia Golombek; Philipp J. Kahle ABSTRACT Depolarized mitochondria are degraded by mitophagy in a process that depends on the Parkinson's disease gene products PINK1 and Parkin. This is accompanied by ubiquitylation of several mitochondrial substrates. The roles...

...Masamune Aihara; Xiulian Jin; Yusuke Kurihara; Yutaka Yoshida; Yuichi Matsushima; Masahide Oku; Yuko Hirota; Tetsu Saigusa; Yoshimasa Aoki; Takeshi Uchiumi; Tadashi Yamamoto; Yasuyoshi Sakai; Dongchon Kang; Tomotake Kanki ABSTRACT When mitophagy is induced in Saccharomyces cerevisiae...

...Thomas D. B. MacVicar; Jon D. Lane ABSTRACT Mitochondrial dynamics play crucial roles in mitophagy-based mitochondrial quality control, but how these pathways are regulated to meet cellular energy demands remains obscure. Using non-transformed human RPE1 cells, we report that upregulation...

...Maika Deffieu; Ingrid Bhatia-Kiššová; Bénédicte Salin; Daniel J. Klionsky; Benoît Pinson; Stéphen Manon; Nadine Camougrand Summary Mitochondria are essential organelles producing most of the energy required for the cell. A selective autophagic process called mitophagy removes damaged mitochondria...