.... and Orrenius , S. ( 2002 ). Cytochrome c release from mitochondria proceeds by a two-step process . Proc. Natl. Acad. Sci. U.S.A. 99 , 1259 - 1263 . 10.1073/pnas.241655498 Palikaras , K. , Lionaki , E. and Tavernarakis , N. ( 2018 ). Mechanisms of mitophagy in cellular...

.... A. ( 2012 ). Mitophagy in cells with mtDNA mutations: being sick is not enough . Autophagy 8 , 699 - 700 . 10.4161/auto.19470 Diot , A. , Hinks-Roberts , A. , Lodge , T. , Liao , C. , Dombi , E. , Morten , K. , Brady , S. , Fratter , C. , Carver , J...

...Jasvinder Kaur; Juliet Goldsmith; Alexandra Tankka; Sofía Bustamante Eguiguren; Alfredo A. Gimenez; Lance Vick; Jayanta Debnath; Ariadne Vlahakis ABSTRACT In Saccharomyces cerevisiae , the selective autophagic degradation of mitochondria, termed mitophagy, is critically regulated by the adapter...

..., the function of which remains to be elucidated. Here, we report that mitochondrial survivin inhibits the selective form of autophagy called ‘mitophagy’, causing an accumulation of respiratory-defective mitochondria. Mechanistically, the data reveal that survivin prevents recruitment of the E3-ubiquitin ligase...

...Pierre Vigié; Elodie Cougouilles; Ingrid Bhatia-Kiššová; Bénédicte Salin; Corinne Blancard; Nadine Camougrand ABSTRACT Mitophagy, the selective degradation of mitochondria by autophagy, is a central process that is essential for the maintenance of cell homeostasis. It is implicated in the clearance...

..., their distinguishing characteristics and modes of lethality. (A) Excessive bulk autophagy, resulting from a massive induction of autophagosomes and autolysosomes. Although membrane integrity is maintained, there is ballooning of the perinuclear space (PNS). (B) Excessive mitophagy, autophagy-dependent selective...

... pathophysiology are examined. Selective autophagy Fanconi anemia Mitophagy Inflammasome Virophagy DNA damage response Fanconi anemia (FA), first described by Guido Fanconi in 1927, is a rare and potentially devastating disease associated with inactivating homozygous or compound heterozygous...

... zygotes and prevent clonal expansion of selfish mitochondrial DNA. This effect requires mitochondrial fission and autophagy. mtDNA Uncoupler Heteroplasmy Mitophagy Mitochondrial dynamics ATG32 Eukaryotic cells usually carry multiple copies of mitochondrial DNA (mtDNA). However, due...

... constitutively low levels of GP78 in healthy cells, in turn downregulating mitophagy. GP78, however, does not regulate MGRN1. When mitochondria are stressed, cytosolic Ca 2+ increases. This leads to a reduced interaction between MGRN1 and GP78 and its compromised ubiquitylation. Chelating Ca 2+ restores...

... of mitochondrial proteins and whole organelles via the proteasome and the autophagy-lysosome pathway (mitophagy). The mitochondrial kinase PINK1 activates and recruits the E3 ubiquitin ligase Parkin to de-energized mitochondria. However, the cognate E2 co-enzymes of Parkin in this ubiquitin-dependent pathway have...

...Sven Geisler; Stefanie Vollmer; Sonia Golombek; Philipp J. Kahle ABSTRACT Depolarized mitochondria are degraded by mitophagy in a process that depends on the Parkinson's disease gene products PINK1 and Parkin. This is accompanied by ubiquitylation of several mitochondrial substrates. The roles...

...Masamune Aihara; Xiulian Jin; Yusuke Kurihara; Yutaka Yoshida; Yuichi Matsushima; Masahide Oku; Yuko Hirota; Tetsu Saigusa; Yoshimasa Aoki; Takeshi Uchiumi; Tadashi Yamamoto; Yasuyoshi Sakai; Dongchon Kang; Tomotake Kanki ABSTRACT When mitophagy is induced in Saccharomyces cerevisiae...

...Thomas D. B. MacVicar; Jon D. Lane ABSTRACT Mitochondrial dynamics play crucial roles in mitophagy-based mitochondrial quality control, but how these pathways are regulated to meet cellular energy demands remains obscure. Using non-transformed human RPE1 cells, we report that upregulation...

...Maika Deffieu; Ingrid Bhatia-Kiššová; Bénédicte Salin; Daniel J. Klionsky; Benoît Pinson; Stéphen Manon; Nadine Camougrand Summary Mitochondria are essential organelles producing most of the energy required for the cell. A selective autophagic process called mitophagy removes damaged mitochondria...

...Eisuke Itakura; Chieko Kishi-Itakura; Ikuko Koyama-Honda; Noboru Mizushima Mitochondria can be degraded by autophagy in a process termed mitophagy. The Parkinson-disease-associated ubiquitin ligase Parkin can trigger mitophagy of depolarized mitochondria. However, it remains to be determined how...

... mitochondria have been proposed to be targeted for selective degradation by mitophagy, thereby providing a quality control system for mitochondria. In yeast, conflicting results concerning the role of mitochondrial dynamics in mitophagy have been reported. Here, we investigate the effects on mitophagy...

... . Chen H. , Chan D. C. ( 2004 ). Mitochondrial dynamics in mammals . Curr. Top. Dev. Biol. 59 , 119 - 144 . Chen H. , Chan D. C. ( 2009 ). Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases . Hum. Mol. Genet. 18 , R169 - R176...