... proteins are mistargeted to various cellular compartments upon mitochondrial dysfunction. We review the fate of these mistargeted proteins and how quality control mechanisms mitigate their accumulation to maintain proteostasis. Mitochondrial stress Mitochondrial protein import Protein quality...

... interactors MAPL, ATAD1 and TRABD. We show that TRABD is likely involved in carrier protein translocation. Mitochondria Mitochondrial biogenesis Protein transport TOM complex Mitochondrial quality control Mitochondrial protein import Ministry for Science and Culture of Lower Saxony http...

... for mitochondrial protein import compared to other eukaryotes with multiple mitochondria. Based on putative mitochondrial TP sequences in the unicellular red alga Cyanidioschyzon merolae , we designed synthetic TPs and showed that functional TPs must have at least one basic residue and a specific amino acid...

... . Mol. Cell   64 , 148 - 162 . 10.1016/j.molcel.2016.08.020 Martinez-Caballero , S. , Grigoriev , S. M. , Herrmann , J. M. , Campo , M. L. and Kinnally , K. W. ( 2007 ). Tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import...

... dissection and assembly of the general import pore complex. Mol. Cell Biol. 18 , 6515 -6524. Goping, I. S., Millar, D. G. and Shore, G. C. ( 1995 ). Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. FEBS Lett. 373 , 45 -50...