... by TOMM20 ) and inner membrane (TIM23, encoded by TIMM23 ) while associating with TOM40 ( TOMM40 ). Intriguingly, this interaction affects mitochondrial morphology, but not protein import or respiratory function; raising the prospect of an intrinsic rescue mechanism. Indeed, Tau P301L induced the formation...

... with the outer membrane proteins Por1 and Om14. Additionally, Cqd1 is important for maintaining mitochondrial homeostasis. Mitochondria Contact sites UbiB protein family Phospholipids Mitochondrial biogenesis Mitochondrial morphology Jung-Stiftung für Wissenschaft und Forschung http...

... distinct roles in associations with partner subunits, thereby maintaining carrier translocase integrity. Mitochondria TIM22 complex Polytopic protein import Mitochondrial morphology Mitochondrial DNA Department of Science and Technology, Ministry of Science and Technology, India DST...

... that is involved in mitochondrial morphology. Here, we describe the LETM1-mediated regulation of the mitochondrial volume and its interaction with the mitochondrial AAA-ATPase BCS1L that is responsible for three different human disorders. LETM1 is a mitochondrial inner-membrane protein with a large domain...

...-negative activity, yielding normal mitochondrial morphology with an elongated tubular network ( Fig. 2A ; micrographs not shown). This normal mitochondrial morphology in the presence of Mfn2 T130A,ΔTM is noteworthy since it has been shown, as mentioned above, that even a loss-of-function mutant of Mfn2...

.... Human MTP18 is a novel nuclear-encoded mitochondrial membrane protein, implicated in controlling mitochondrial fission. Upon overexpression of MTP18, mitochondrial morphology was altered from filamentous to punctate structures suggesting excessive mitochondrial fission. Mitochondrial fragmentation...

... into mitochondria or resulting accumulation of precursor forms of mitochondrial proteins outside the mitochondria are not the causal reason for the aberrant mitochondrial morphology. By contrast, deletion of Mdj1p, a functional partner for mitochondrial Hsp70 in prevention of irreversible protein aggregation...