...Christoph Datler; Evangelos Pazarentzos; Anne-Laure Mahul-Mellier; Wanwisa Chaisaklert; Ming-Shih Hwang; Foy Osborne; Stefan Grimm ABSTRACT The permeability transition pore (PT-pore) mediates cell death through the dissipation of the mitochondrial membrane potential (ΔΨ m). Because the exact...

... negative mitochondrial membrane potential (ΔΨ) for import, we examined the magnitude of ΔΨ in hepatocytes and astrocytes. Our results unexpectedly revealed that ΔΨ in hepatocytes is considerably more negative than that of astrocytes and that converting the targeting signal into ‘strong’ MTS abolished...

... Mitochondrial membrane potential Programmed cell death or apoptosis is a controlled cell-suicide process that has great importance in maintaining the normal physiological function of a biological organism (Vaux and Korsmeyer, 1999). The malfunction of apoptosis is also closely related to many diseases...

... effect. In addition, we found unexpectedly that overexpression of the deletion mutant composed of one short region each in the N- and C-terminal tails of Mfn2 resulted in loss of mitochondrial membrane potential, suggesting that Mfn2 might also be connected to maintenance of mitochondrial membrane...

... permeabilization coordinates the depolarization of both membrane potentials during apoptosis. Apoptosis Mitochondrial membrane potential Plasma membrane potential Confocal imaging Mitochondrial respiration Mitochondria produce ATP and control cellular energetics(Nicholls and Ward, 2000). However...

... for correspondence (e-mail: [email protected]) 16 02 2001 © 2001 by Company of Biologists 2001 Apoptosis Carbonyl cyanide m -chlorophenylhydrazone Cyclosporin A Mitochondrial membrane potential Mitochondrial permeability transition Photoreceptors Tetramethylrhodamine ethyl ester Tiger...